Literature DB >> 25990089

Liver sharing and organ procurement organization performance under redistricted allocation.

Sommer E Gentry1,2, Eric K H Chow1, Allan Massie1,3, Xun Luo1, Eugene Shteyn4, Joshua Pyke4, David Zaun4, Jon J Snyder4,5, Ajay K Israni4,5,6, Bert Kasiske4,6, Dorry L Segev1,3.   

Abstract

Concerns have been raised that optimized redistricting of liver allocation areas might have the unintended result of shifting livers from better-performing to poorer-performing organ procurement organizations (OPOs). We used liver simulated allocation modeling to simulate a 5-year period of liver sharing within either 4 or 8 optimized districts. We investigated whether each OPO's net liver import under redistricting would be correlated with 2 OPO performance metrics (observed to expected liver yield and liver donor conversion ratio), along with 2 other potential correlates (eligible deaths and incident listings above a Model for End-Stage Liver Disease score of 15). We found no evidence that livers would flow from better-performing OPOs to poorer-performing OPOs in either redistricting scenario. Instead, under these optimized redistricting plans, our simulations suggest that livers would flow from OPOs with more-than-expected eligible deaths toward those with fewer-than-expected eligible deaths and that livers would flow from OPOs with fewer-than-expected incident listings to those with more-than-expected incident listings; the latter is a pattern that is already established in the current allocation system. Redistricting liver distribution to reduce geographic inequity is expected to align liver allocation across the country with the distribution of supply and demand rather than transferring livers from better-performing OPOs to poorer-performing OPOs.
© 2015 American Association for the Study of Liver Diseases.

Entities:  

Mesh:

Year:  2015        PMID: 25990089      PMCID: PMC4516652          DOI: 10.1002/lt.24171

Source DB:  PubMed          Journal:  Liver Transpl        ISSN: 1527-6465            Impact factor:   5.799


  12 in total

1.  Geographic differences in event rates by model for end-stage liver disease score.

Authors:  J P Roberts; D M Dykstra; N P Goodrich; S H Rush; R M Merion; F K Port
Journal:  Am J Transplant       Date:  2006-10       Impact factor: 8.086

2.  Organ donation and utilization in the United States, 1997-2006.

Authors:  R S Sung; J Galloway; J E Tuttle-Newhall; T Mone; R Laeng; C E Freise; P S Rao
Journal:  Am J Transplant       Date:  2008-04       Impact factor: 8.086

3.  Geographic favoritism in liver transplantation--unfortunate or unfair?

Authors:  P A Ubel; A L Caplan
Journal:  N Engl J Med       Date:  1998-10-29       Impact factor: 91.245

4.  Liver sharing and organ procurement organization performance.

Authors:  Sommer E Gentry; Eric K H Chow; Allan Massie; Xun Luo; David Zaun; Jon J Snyder; Ajay K Israni; Bert Kasiske; Dorry L Segev
Journal:  Liver Transpl       Date:  2015-03       Impact factor: 5.799

5.  Investigating geographic variation in mortality in the context of organ donation.

Authors:  E Sheehy; K J O'Connor; R S Luskin; R J Howard; D Cornell; J Finn; T Mone; F W Selck; F L Delmonico
Journal:  Am J Transplant       Date:  2012-03-24       Impact factor: 8.086

6.  MELD Exceptions and Rates of Waiting List Outcomes.

Authors:  A B Massie; B Caffo; S E Gentry; E C Hall; D A Axelrod; K L Lentine; M A Schnitzler; A Gheorghian; P R Salvalaggio; D L Segev
Journal:  Am J Transplant       Date:  2011-09-15       Impact factor: 8.086

7.  Addressing geographic disparities in liver transplantation through redistricting.

Authors:  S E Gentry; A B Massie; S W Cheek; K L Lentine; E H Chow; C E Wickliffe; N Dzebashvili; P R Salvalaggio; M A Schnitzler; D A Axelrod; D L Segev
Journal:  Am J Transplant       Date:  2013-07-09       Impact factor: 8.086

8.  Following the organ supply: assessing the benefit of inter-DSA travel in liver transplantation.

Authors:  Nino Dzebisashvili; Allan B Massie; Krista L Lentine; Mark A Schnitzler; Dorry Segev; Janet Tuttle-Newhall; Sommer Gentry; Richard Freeman; David A Axelrod
Journal:  Transplantation       Date:  2013-01-27       Impact factor: 4.939

9.  Geographic disparities in deceased donor liver transplantation within a single UNOS region.

Authors:  Neal R Barshes; Natasha S Becker; W Kenneth Washburn; Glenn A Halff; Thomas A Aloia; John A Goss
Journal:  Liver Transpl       Date:  2007-05       Impact factor: 5.799

10.  Variation in access to the liver transplant waiting list in the United States.

Authors:  Amit K Mathur; Valarie B Ashby; Douglas S Fuller; Min Zhang; Robert M Merion; Alan Leichtman; John Kalbfleisch
Journal:  Transplantation       Date:  2014-07-15       Impact factor: 4.939

View more
  4 in total

1.  Current Issues in Liver Transplantation.

Authors:  James F Trotter
Journal:  Gastroenterol Hepatol (N Y)       Date:  2016-04

2.  Important Facts About Organ Donation and OPO Performance.

Authors:  David S Goldberg; Teresa Shafer; Laura Siminoff
Journal:  Transplantation       Date:  2018-05       Impact factor: 4.939

3.  Ensuring the need is met: A 50-year simulation study of the National Kidney Registry's family voucher program.

Authors:  Matthew Cooper; David B Leeser; Stuart M Flechner; Jennifer L Beaumont; Amy D Waterman; Patrick W Shannon; Matthew Ronin; Garet Hil; Jeffrey L Veale
Journal:  Am J Transplant       Date:  2020-06-25       Impact factor: 8.086

4.  Squaring the circle of selection and allocation in liver transplantation for HCC: An adaptive approach.

Authors:  Vincenzo Mazzaferro
Journal:  Hepatology       Date:  2016-02-26       Impact factor: 17.425

  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.