Literature DB >> 25987630

Effect of Resistance Mechanisms on the Inoculum Effect of Carbapenem in Klebsiella pneumoniae Isolates with Borderline Carbapenem Resistance.

Amos Adler1, Ma'ayan Ben-Dalak2, Ina Chmelnitsky2, Yehuda Carmeli2.   

Abstract

We aimed to examine the effects of resistance mechanisms on several resistance phenotypes among carbapenem-resistant Klebsiella pneumoniae isolates with borderline carbapenem MICs. We compared carbapenemase-negative K. pneumoniae with carbapenemase-producing K. pneumoniae (CPKP) isolates with similar MICs. CPKP isolates exhibited a marked inoculum effect and were more resistant to the bactericidal effect of meropenem. This suggests that MIC measurements alone may not be sufficient in predicting the therapeutic efficacy of carbapenems against CPKP.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 25987630      PMCID： PMC4505287          DOI： 10.1128/AAC.00533-15

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  17 in total

1.  Rapid detection of carbapenemase genes by multiplex real-time PCR.

Authors:  Jussimara Monteiro; Raymond H Widen; Antonio C C Pignatari; Carly Kubasek; Suzane Silbert
Journal:  J Antimicrob Chemother       Date:  2012-01-09       Impact factor: 5.790

2.  Multiplex PCR for rapid detection of genes encoding CTX-M extended-spectrum (beta)-lactamases.

Authors:  Neil Woodford; Elizabeth J Fagan; Matthew J Ellington
Journal:  J Antimicrob Chemother       Date:  2005-11-10       Impact factor: 5.790

3.  Rapid detection and identification of metallo-beta-lactamase-encoding genes by multiplex real-time PCR assay and melt curve analysis.

Authors:  Rodrigo E Mendes; Katia A Kiyota; Jussimara Monteiro; Mariana Castanheira; Soraya S Andrade; Ana C Gales; Antonio C C Pignatari; Sergio Tufik
Journal:  J Clin Microbiol       Date:  2006-11-08       Impact factor: 5.948

4.  Porin alterations present in non-carbapenemase-producing Enterobacteriaceae with high and intermediate levels of carbapenem resistance in Chile.

Authors:  Aniela Wozniak; Nicolás A Villagra; Agustina Undabarrena; Natalia Gallardo; Nicole Keller; Marcela Moraga; Juan C Román; Guido C Mora; Patricia García
Journal:  J Med Microbiol       Date:  2012-06-14       Impact factor: 2.472

5.  Influence of inoculum size of Staphylococcus aureus and Pseudomonas aeruginosa on in vitro activities and in vivo efficacy of fluoroquinolones and carbapenems.

Authors:  Shingo Mizunaga; Tomoko Kamiyama; Yoshiko Fukuda; Masahiro Takahata; Junichi Mitsuyama
Journal:  J Antimicrob Chemother       Date:  2005-05-12       Impact factor: 5.790

6.  Identification of CTX-M-type extended-spectrum-beta-lactamase genes using real-time PCR and pyrosequencing.

Authors:  Thierry Naas; Cynthia Oxacelay; Patrice Nordmann
Journal:  Antimicrob Agents Chemother       Date:  2006-11-06       Impact factor: 5.191

7.  Genetic factors associated with elevated carbapenem resistance in KPC-producing Klebsiella pneumoniae.

Authors:  Brandon Kitchel; J Kamile Rasheed; Andrea Endimiani; Andrea M Hujer; Karen F Anderson; Robert A Bonomo; Jean B Patel
Journal:  Antimicrob Agents Chemother       Date:  2010-07-26       Impact factor: 5.191

8.  Comparative in vitro pharmacodynamics of imipenem and meropenem against Pseudomonas aeruginosa.

Authors:  R White; L Friedrich; D Burgess; D Warkentin; J Bosso
Journal:  Antimicrob Agents Chemother       Date:  1996-04       Impact factor: 5.191

9.  Dissemination of the CTX-M-25 family beta-lactamases among Klebsiella pneumoniae, Escherichia coli and Enterobacter cloacae and identification of the novel enzyme CTX-M-41 in Proteus mirabilis in Israel.

Authors:  Shiri Navon-Venezia; Inna Chmelnitsky; Azita Leavitt; Yehuda Carmeli
Journal:  J Antimicrob Chemother       Date:  2008-05-16       Impact factor: 5.790

10.  Contribution of OmpK36 to carbapenem susceptibility in KPC-producing Klebsiella pneumoniae.

Authors:  David Landman; Simona Bratu; John Quale
Journal:  J Med Microbiol       Date:  2009-06-25       Impact factor: 2.472
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  16 in total

1.  Comparative Study of a Novel Biochemical Assay, the Rapidec Carba NP Test, for Detecting Carbapenemase-Producing Enterobacteriaceae.

Authors:  Ziv Lifshitz; Amos Adler; Yehuda Carmeli
Journal:  J Clin Microbiol       Date:  2015-11-18       Impact factor: 5.948

2.  Inoculum effect of β-lactam antibiotics.

Authors:  Justin R Lenhard; Zackery P Bulman
Journal:  J Antimicrob Chemother       Date:  2019-10-01       Impact factor: 5.790

3.  New Polymyxin B Dosing Strategies To Fortify Old Allies in the War against KPC-2-Producing Klebsiella pneumoniae.

Authors:  Zackery P Bulman; Michael J Satlin; Liang Chen; Barry N Kreiswirth; Beom Soo Shin; Thomas J Walsh; Patricia N Holden; Alan Forrest; Roger L Nation; Jian Li; Brian T Tsuji
Journal:  Antimicrob Agents Chemother       Date:  2017-03-24       Impact factor: 5.191

4.  The Inoculum Effect in the Era of Multidrug Resistance: Minor Differences in Inoculum Have Dramatic Effect on MIC Determination.

Authors:  Kenneth P Smith; James E Kirby
Journal:  Antimicrob Agents Chemother       Date:  2018-07-27       Impact factor: 5.191

5.  Improvement of the Xpert Carba-R Kit for the Detection of Carbapenemase-Producing Enterobacteriaceae.

Authors:  Laurent Dortet; Mathieu Fusaro; Thierry Naas
Journal:  Antimicrob Agents Chemother       Date:  2016-05-23       Impact factor: 5.191

Review 6.  The Epidemiology, Evolution, and Treatment of KPC-Producing Organisms.

Authors:  Ann Marie Porreca; Kaede V Sullivan; Jason C Gallagher
Journal:  Curr Infect Dis Rep       Date:  2018-05-05       Impact factor: 3.725

7.  Treatment outcome of non-carbapenemase-producing carbapenem-resistant Klebsiella pneumoniae infections: a multicenter study in Taiwan.

Authors:  Chin-Fang Su; Chien Chuang; Yi-Tsung Lin; Yu-Jiun Chan; Jung-Chung Lin; Po-Liang Lu; Ching-Tai Huang; Jann-Tay Wang; Yin-Ching Chuang; L Kristopher Siu; Chang-Phone Fung
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2017-12-14       Impact factor: 3.267

8.  Meropenem dosing requirements against Enterobacteriaceae in critically ill patients: influence of renal function, geographical area and presence of extended-spectrum β-lactamases.

Authors:  A Isla; A Canut; J Arribas; E Asín-Prieto; A Rodríguez-Gascón
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2016-01-19       Impact factor: 3.267

9.  In Vitro Activity of Imipenem against Carbapenemase-Positive Enterobacteriaceae Isolates Collected by the SMART Global Surveillance Program from 2008 to 2014.

Authors:  James A Karlowsky; Sibylle H Lob; Krystyna M Kazmierczak; Robert E Badal; Katherine Young; Mary R Motyl; Daniel F Sahm
Journal:  J Clin Microbiol       Date:  2017-03-15       Impact factor: 5.948

10.  Antimicrobial Effects of β-Lactams on Imipenem-Resistant Ceftazidime-Susceptible Pseudomonas aeruginosa.

Authors:  Yu Mi Wi; Ji-Young Choi; Ji-Young Lee; Cheol-In Kang; Doo Ryeon Chung; Kyong Ran Peck; Jae-Hoon Song; Kwan Soo Ko
Journal:  Antimicrob Agents Chemother       Date:  2017-05-24       Impact factor: 5.191
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