| Literature DB >> 25986963 |
Suryawanshi Rahul1, Patil Chandrashekhar1, Borase Hemant1, Salunke Bipinchandra1, Elisabeth Mouray2, Philippe Grellier2, Patil Satish3.
Abstract
Bioactive pigments were extracted and purified from cultures of Serratia marcescens and Chromobacterium violaceum. Spectroscopic, FTIR, and HPLC analyses showed prodigiosin and violacein as the principle molecules in the extract. Bioactive microbial pigments prodigiosin, violacein and their combinations with phytosynthesized silver and gold nanoparticles were studied for in vitro growth inhibition of Plasmodium falciparum and Trypanosoma brucei gambiense. Prodigiosin was found to be more effective than violacein for inhibition of both parasites in vitro. Specifically, combinations of the microbial pigment prodigiosin with metal nanoparticles showed a significant decrease in the IC50 values on both parasites (2.7 to 3.6 fold) without increase of cytotoxicity upon mammalian cells. The data may be useful for the microbial pigment based drug designing.Entities:
Keywords: Antimalarial; Plasmodium falciparum; Prodigiosin; Trypanosoma brucei gambiense; Violacein
Mesh：
Substances：
Year: 2015 PMID： 25986963 DOI： 10.1016/j.parint.2015.05.004
Source DB: PubMed Journal: Parasitol Int ISSN： 1383-5769 Impact factor: 2.230