Literature DB >> 25963333

A subset of genetic susceptibility variants for colorectal cancer also has prognostic value.

S Noci1, M Dugo2, F Bertola3, F Melotti4, A Vannelli5, T A Dragani1, A Galvan1.   

Abstract

We investigated the possible influence of 86 single-nucleotide polymorphisms (SNPs), known to associate with the risk of colorectal cancer (CRC), on overall survival and time to recurrence (TTR) in 733 Italian CRC patients followed up for up to 84 months after surgery. In the Cox multivariate analysis, adjusted for gender, age, pathological stage and adjuvant chemotherapy (yes/no), the risk of death significantly increased by rare allele count (P<0.05) for rs1801133 (MTHFR), rs4939827 (SMAD7), rs2306283 (SLCO1B1) and rs12898159 (BMP4), whereas for rs736775 (GPX3) the opposite was observed. Two additional SNPs associated with TTR, namely rs16892766 (downstream of EIF3H) and rs10749971 (COLCA2). Our findings show that some genetic variants previously found to associate with CRC risk are also associated with survival after treatment. The identification of alleles defining subgroups of patients with worse clinical outcome may have application in developing pharmacogenetic strategies aimed at personalizing CRC treatment.

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Year:  2015        PMID： 25963333     DOI： 10.1038/tpj.2015.35

Source DB:  PubMed          Journal:  Pharmacogenomics J        ISSN： 1470-269X            Impact factor:   3.550


  33 in total

1.  CYBRD1 as a modifier gene that modulates iron phenotype in HFE p.C282Y homozygous patients.

Authors:  Sara Pelucchi; Raffaella Mariani; Stefano Calza; Anna Ludovica Fracanzani; Giulia Litta Modignani; Francesca Bertola; Fabiana Busti; Paola Trombini; Mirella Fraquelli; Gian Luca Forni; Domenico Girelli; Silvia Fargion; Claudia Specchia; Alberto Piperno
Journal:  Haematologica       Date:  2012-07-06       Impact factor: 9.941

2.  The 14q22.2 colorectal cancer variant rs4444235 shows cis-acting regulation of BMP4.

Authors:  S J Lubbe; A M Pittman; B Olver; A Lloyd; J Vijayakrishnan; S Naranjo; S Dobbins; P Broderick; J L Gómez-Skarmeta; R S Houlston
Journal:  Oncogene       Date:  2011-12-12       Impact factor: 9.867

3.  GWAS-identified colorectal cancer susceptibility locus associates with disease prognosis.

Authors:  Jinliang Xing; Ronald E Myers; Xianli He; Falin Qu; Feng Zhou; Xi Ma; Terry Hyslop; Guoqiang Bao; Shaogui Wan; Hushan Yang; Zhinan Chen
Journal:  Eur J Cancer       Date:  2011-03-12       Impact factor: 9.162

Review 4.  Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake.

Authors:  Mikko Niemi; Marja K Pasanen; Pertti J Neuvonen
Journal:  Pharmacol Rev       Date:  2011-01-18       Impact factor: 25.468

Review 5.  C677T and A1298C MTHFR polymorphisms, a challenge for antifolate and fluoropyrimidine-based therapy personalisation.

Authors:  Elena De Mattia; Giuseppe Toffoli
Journal:  Eur J Cancer       Date:  2009-01-12       Impact factor: 9.162

6.  Association of molecular markers with toxicity outcomes in a randomized trial of chemotherapy for advanced colorectal cancer: the FOCUS trial.

Authors:  Michael S Braun; Susan D Richman; Lindsay Thompson; Catherine L Daly; Angela M Meade; Julian W Adlard; James M Allan; Mahesh K B Parmar; Philip Quirke; Matthew T Seymour
Journal:  J Clin Oncol       Date:  2009-10-26       Impact factor: 44.544

7.  Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics.

Authors:  Federico Innocenti; Deanna L Kroetz; Erin Schuetz; M Eileen Dolan; Jacqueline Ramírez; Mary Relling; Peixian Chen; Soma Das; Gary L Rosner; Mark J Ratain
Journal:  J Clin Oncol       Date:  2009-04-06       Impact factor: 44.544

8.  A siRNA screen identifies RAD21, EIF3H, CHRAC1 and TANC2 as driver genes within the 8q23, 8q24.3 and 17q23 amplicons in breast cancer with effects on cell growth, survival and transformation.

Authors:  Sardar Faisal Mahmood; Nadège Gruel; Elodie Chapeaublanc; Aurianne Lescure; Thouis Jones; Fabien Reyal; Anne Vincent-Salomon; Virginie Raynal; Gaëlle Pierron; Franck Perez; Jacques Camonis; Elaine Del Nery; Olivier Delattre; François Radvanyi; Isabelle Bernard-Pierrot
Journal:  Carcinogenesis       Date:  2013-10-22       Impact factor: 4.944

9.  Multiple common susceptibility variants near BMP pathway loci GREM1, BMP4, and BMP2 explain part of the missing heritability of colorectal cancer.

Authors:  Ian P M Tomlinson; Luis G Carvajal-Carmona; Sara E Dobbins; Albert Tenesa; Angela M Jones; Kimberley Howarth; Claire Palles; Peter Broderick; Emma E M Jaeger; Susan Farrington; Annabelle Lewis; James G D Prendergast; Alan M Pittman; Evropi Theodoratou; Bianca Olver; Marion Walker; Steven Penegar; Ella Barclay; Nicola Whiffin; Lynn Martin; Stephane Ballereau; Amy Lloyd; Maggie Gorman; Steven Lubbe; Bryan Howie; Jonathan Marchini; Clara Ruiz-Ponte; Ceres Fernandez-Rozadilla; Antoni Castells; Angel Carracedo; Sergi Castellvi-Bel; David Duggan; David Conti; Jean-Baptiste Cazier; Harry Campbell; Oliver Sieber; Lara Lipton; Peter Gibbs; Nicholas G Martin; Grant W Montgomery; Joanne Young; Paul N Baird; Steven Gallinger; Polly Newcomb; John Hopper; Mark A Jenkins; Lauri A Aaltonen; David J Kerr; Jeremy Cheadle; Paul Pharoah; Graham Casey; Richard S Houlston; Malcolm G Dunlop
Journal:  PLoS Genet       Date:  2011-06-02       Impact factor: 5.917

10.  Methylenetetrahydrofolate reductase genetic polymorphisms and toxicity to 5-FU-based chemoradiation in rectal cancer.

Authors:  F Thomas; A A Motsinger-Reif; J M Hoskins; A Dvorak; S Roy; A Alyasiri; R J Myerson; J W Fleshman; B R Tan; H L McLeod
Journal:  Br J Cancer       Date:  2011-11-01       Impact factor: 7.640
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  8 in total

Review 1.  Single Nucleotide Polymorphism in SMAD7 and CHI3L1 and Colorectal Cancer Risk.

Authors:  Amal Ahmed Abd El-Fattah; Nermin Abdel Hamid Sadik; Olfat Gamil Shaker; Amal Mohamed Kamal
Journal:  Mediators Inflamm       Date:  2018-10-25       Impact factor: 4.711

2.  Methylenetetrahydrofolate reductase C677T polymorphism and colorectal cancer susceptibility: a meta-analysis.

Authors:  Lingyan Xu; Zhiqiang Qin; Feng Wang; Shuhui Si; Lele Li; Peinan Lin; Xiao Han; Xiaomin Cai; Haiwei Yang; Yanhong Gu
Journal:  Biosci Rep       Date:  2017-12-07       Impact factor: 3.840

3.  SMAD7 polymorphisms and colorectal cancer risk: a meta-analysis of case-control studies.

Authors:  Yongsheng Huang; Wenting Wu; Meng Nie; Chuang Li; Lin Wang
Journal:  Oncotarget       Date:  2016-11-15

4.  Complex genetic control of lung tumorigenesis in resistant mice strains.

Authors:  Alice Dassano; Giulia Pintarelli; Chiara E Cotroneo; Angela Pettinicchio; Elena Forcati; Loris De Cecco; Andrea Borrego; Francesca Colombo; Tommaso A Dragani; Giacomo Manenti
Journal:  Cancer Sci       Date:  2017-10-06       Impact factor: 6.716

5.  Effects of GSTA1 and GPX3 Polymorphisms on the Risk of Schizophrenia in Chinese Han Population.

Authors:  Chao Liu; Sijia Song; Junkai Zhang; Xiao Li; Huijie Gao
Journal:  Neuropsychiatr Dis Treat       Date:  2020-01-09       Impact factor: 2.570

6.  Identifying Transcriptomic Signatures and Rules for SARS-CoV-2 Infection.

Authors:  Yu-Hang Zhang; Hao Li; Tao Zeng; Lei Chen; Zhandong Li; Tao Huang; Yu-Dong Cai
Journal:  Front Cell Dev Biol       Date:  2021-01-11

7.  Prognosis Prediction for Colorectal Cancer Patients: A Risk Score Based on The Metabolic-Related Genes.

Authors:  Yongqu Lu; Xin Zhou; Zhenzhen Liu; Wendong Wang; Siyi Lu; Wei Fu
Journal:  Int J Med Sci       Date:  2021-01-01       Impact factor: 3.738

8.  Gut microbiota composition in colorectal cancer patients is genetically regulated.

Authors:  Francesca Colombo; Oscar Illescas; Sara Noci; Francesca Minnai; Giulia Pintarelli; Angela Pettinicchio; Alberto Vannelli; Luca Sorrentino; Luigi Battaglia; Maurizio Cosimelli; Tommaso A Dragani; Manuela Gariboldi
Journal:  Sci Rep       Date:  2022-07-06       Impact factor: 4.996
  8 in total

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