Na Zhu1, David R Jacobs2, Pamela J Schreiner1, Lenore J Launer1, Rachel A Whitmer1, Stephen Sidney1, Ellen Demerath1, William Thomas1, Claude Bouchard1, Ka He1, Guray Erus1, Harsha Battapady1, R Nick Bryan1. 1. From the Divisions of Epidemiology and Community Health (N.Z., D.R.J., P.J.S., E.D.) and Biostatistics (W.T.), School of Public Health, University of Minnesota; St. Barnabas Hospital (N.Z.), affiliated with Albert Einstein College of Medicine; Neuroepidemiology Section (L.J.L.), NIA; Kaiser Permanente Division of Research (R.A.W., S.S.); Human Genomics (C.B.), Pennington Biomedical Research Center; School of Public Health (K.H.), Indiana University Bloomington; and Department of Radiology (G.E., H.B., R.N.B.), University of Pennsylvania. 2. From the Divisions of Epidemiology and Community Health (N.Z., D.R.J., P.J.S., E.D.) and Biostatistics (W.T.), School of Public Health, University of Minnesota; St. Barnabas Hospital (N.Z.), affiliated with Albert Einstein College of Medicine; Neuroepidemiology Section (L.J.L.), NIA; Kaiser Permanente Division of Research (R.A.W., S.S.); Human Genomics (C.B.), Pennington Biomedical Research Center; School of Public Health (K.H.), Indiana University Bloomington; and Department of Radiology (G.E., H.B., R.N.B.), University of Pennsylvania. jacob004@umn.edu.
Abstract
OBJECTIVE: We hypothesized that greater cardiorespiratory fitness is associated with lower odds of having unfavorable brain MRI findings. METHODS: We studied 565 healthy, middle-aged, black and white men and women in the CARDIA (Coronary Artery Risk Development in Young Adults) Study. The fitness measure was symptom-limited maximal treadmill test duration (Maxdur); brain MRI was measured 5 years later. Brain MRI measures were analyzed as means and as proportions below the 15th percentile (above the 85th percentile for white matter abnormal tissue volume). RESULTS: Per 1-minute-higher Maxdur, the odds ratio for having less whole brain volume was 0.85 (p = 0.04) and for having low white matter integrity was 0.80 (p = 0.02), adjusted for age, race, sex, clinic, body mass index, smoking, alcohol, diet, physical activity, education, blood pressure, diabetes, total cholesterol, and lung function (plus intracranial volume for white matter integrity). No significant associations were observed between Maxdur and abnormal tissue volume or blood flow in white matter. Findings were similar for associations with continuous brain MRI measures. CONCLUSIONS: Greater physical fitness was associated with more brain volume and greater white matter integrity measured 5 years later in middle-aged adults.
OBJECTIVE: We hypothesized that greater cardiorespiratory fitness is associated with lower odds of having unfavorable brain MRI findings. METHODS: We studied 565 healthy, middle-aged, black and white men and women in the CARDIA (Coronary Artery Risk Development in Young Adults) Study. The fitness measure was symptom-limited maximal treadmill test duration (Maxdur); brain MRI was measured 5 years later. Brain MRI measures were analyzed as means and as proportions below the 15th percentile (above the 85th percentile for white matter abnormal tissue volume). RESULTS: Per 1-minute-higher Maxdur, the odds ratio for having less whole brain volume was 0.85 (p = 0.04) and for having low white matter integrity was 0.80 (p = 0.02), adjusted for age, race, sex, clinic, body mass index, smoking, alcohol, diet, physical activity, education, blood pressure, diabetes, total cholesterol, and lung function (plus intracranial volume for white matter integrity). No significant associations were observed between Maxdur and abnormal tissue volume or blood flow in white matter. Findings were similar for associations with continuous brain MRI measures. CONCLUSIONS: Greater physical fitness was associated with more brain volume and greater white matter integrity measured 5 years later in middle-aged adults.
Authors: Na Zhu; David R Jacobs; Stephen Sidney; Barbara Sternfeld; Mercedes Carnethon; Cora E Lewis; Christina M Shay; Akshay Sood; Claude Bouchard Journal: Am J Clin Nutr Date: 2011-06-08 Impact factor: 7.045
Authors: L H Kuller; L Shemanski; T Manolio; M Haan; L Fried; N Bryan; G L Burke; R Tracy; R Bhadelia Journal: Stroke Date: 1998-02 Impact factor: 7.914
Authors: S Sidney; W L Haskell; R Crow; B Sternfeld; A Oberman; M A Armstrong; G R Cutter; D R Jacobs; P J Savage; L Van Horn Journal: Med Sci Sports Exerc Date: 1992-02 Impact factor: 5.411
Authors: Zhiqiang Lao; Dinggang Shen; Dengfeng Liu; Abbas F Jawad; Elias R Melhem; Lenore J Launer; R Nick Bryan; Christos Davatzikos Journal: Acad Radiol Date: 2008-03 Impact factor: 3.173
Authors: J M Burns; B B Cronk; H S Anderson; J E Donnelly; G P Thomas; A Harsha; W M Brooks; R H Swerdlow Journal: Neurology Date: 2008-07-15 Impact factor: 9.910
Authors: Brenna Cholerton; Adam Omidpanah; Tara M Madhyastha; Thomas J Grabowski; Astrid M Suchy-Dicey; Dean K Shibata; Lonnie A Nelson; Steven P Verney; Barbara V Howard; William T Longstreth; Thomas J Montine; Dedra Buchwald Journal: Alzheimer Dis Assoc Disord Date: 2017 Apr-Jun Impact factor: 2.703
Authors: Sanne Verkooijen; Remi Stevelink; Lucija Abramovic; Christiaan H Vinkers; Roel A Ophoff; René S Kahn; Marco P M Boks; Neeltje E M van Haren Journal: Psychiatry Res Neuroimaging Date: 2017-02-09 Impact factor: 2.376
Authors: Junyeon Won; Daniel D Callow; Gabriel S Pena; Marissa A Gogniat; Yash Kommula; Naomi A Arnold-Nedimala; Leslie S Jordan; J Carson Smith Journal: Neurosci Biobehav Rev Date: 2021-10-13 Impact factor: 8.989
Authors: Anna E Mattlage; Michael A Rippee; Michael G Abraham; Janice Sandt; Sandra A Billinger Journal: Neurorehabil Neural Repair Date: 2016-07-04 Impact factor: 3.919
Authors: Matthew T Mefford; Ligong Chen; Cora E Lewis; Paul Muntner; Stephen Sidney; Lenore J Launer; Keri L Monda; Andrea Ruzza; Helina Kassahun; Robert S Rosenson; April P Carson Journal: J Int Neuropsychol Soc Date: 2021-02-10 Impact factor: 2.892