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Literature DB >> 25956415

A fluorescent bisboronic acid compound that selectively labels cells expressing oligosaccharide Lewis X.

Xingming Gao¹, Mengyuan Zhu¹, Haiying Fan², Wenqian Yang¹, Weijuan Ni¹, Vishnu V R Karnati¹, Shouhai Gao¹, John Carson², Brent Weston³, Binghe Wang⁴.

Abstract

Two fluorescent diboronic acid compounds (6a and 6b) with a dipeptide linker were synthesized as potential sensors for cell surface saccharide Lewis X (Le(X)). Compound 6a with a dipeptide (H-Asp-Ala-) as the linker was found to selectively label CHOFUT4 cells, which express Le(x), at micromolar concentrations, while non-Le(x)-expressing control cells were not labeled.

Entities: CellLine Chemical Disease Gene Species

Keywords: Biomarker; Boronolectin; Optical imaging

Mesh：

Substances：

Year: 2015 PMID： 25956415 PMCID： PMC4444404 DOI： 10.1016/j.bmcl.2015.04.069

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

19 in total

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5. Exploiting the reversible covalent bonding of boronic acids: recognition, sensing, and assembly.

Authors: Steven D Bull; Matthew G Davidson; Jean M H van den Elsen; John S Fossey; A Toby A Jenkins; Yun-Bao Jiang; Yuji Kubo; Frank Marken; Kazuo Sakurai; Jianzhang Zhao; Tony D James
Journal: Acc Chem Res Date: 2012-11-14 Impact factor: 22.384

6. A missense mutation in the FUT6 gene results in total absence of alpha3-fucosylation of human alpha1-acid glycoprotein.

Authors: E C Brinkman-Van der Linden; R Mollicone; R Oriol; G Larson; D H Van den Eijnden; W Van Dijk
Journal: J Biol Chem Date: 1996-06-14 Impact factor: 5.157

A fluorescent bisboronic acid compound that selectively labels cells expressing oligosaccharide Lewis X.

1. High sialic acid reactivity of sugar chain structure Lewis-X in patients with mental retardation.

2. Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins.

3. Stage-specific embryonic antigen involves alpha 1 goes to 3 fucosylated type 2 blood group chains.

4. The hapten structure of a developmentally regulated glycolipid antigen (SSEA-1) isolated from human erythrocytes and adenocarcinoma: a preliminary note.

5. Exploiting the reversible covalent bonding of boronic acids: recognition, sensing, and assembly.

6. A missense mutation in the FUT6 gene results in total absence of alpha3-fucosylation of human alpha1-acid glycoprotein.

7. Characterization of sialosylated Lewisx as a new tumor-associated antigen.

8. Diboronic acids as fluorescent probes for cells expressing sialyl Lewis X.

9. The first fluorescent diboronic acid sensor specific for hepatocellular carcinoma cells expressing sialyl Lewis X.

10. Regulation of asialoglycoprotein receptor synthesis by inflammation-related cytokines in HepG2 cells.

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