| Literature DB >> 6386148 |
K Fukushima, M Hirota, P I Terasaki, A Wakisaka, H Togashi, D Chia, N Suyama, Y Fukushi, E Nudelman, S Hakomori.
Abstract
A monoclonal antibody CSLEX1 which reacts with sialosyl Lex but not with sialosyl Lea has been produced. The CSLEX1 antigen has a tissue distribution similar to that of Lex, appearing characteristically in the proximal tubules of the kidney and on granulocytes. It is tumor associated in that 14 of 34 (41%) of tumor lines tested reacted with the CSLEX1 antibody, and 50 of 74 (68%) of tumor tissues tested reacted with the antibody. Loss of immunoperoxidase staining of tissues after neuraminidase treatment showed that the antibody is reacting to sialyl derivatives. The antibody reacted in solid-phase radioimmunoassay to sialosyllactofucopentaosyl(III)ceramide and sialosyldifucosylganglioside (6B). These results indicate that the CSLEX1 epitope has the following structure: (formula: see text) This structure had not previously been known to be tumor associated.Entities:
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Year: 1984 PMID： 6386148
Source DB: PubMed Journal: Cancer Res ISSN： 0008-5472 Impact factor: 12.701