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Literature DB >> 25954010

Chromosomes. CENP-C reshapes and stabilizes CENP-A nucleosomes at the centromere.

Samantha J Falk¹, Lucie Y Guo², Nikolina Sekulic³, Evan M Smoak⁴, Tomoyasu Mani², Glennis A Logsdon², Kushol Gupta³, Lars E T Jansen⁵, Gregory D Van Duyne², Sergei A Vinogradov², Michael A Lampson⁶, Ben E Black⁷.

Abstract

Inheritance of each chromosome depends upon its centromere. A histone H3 variant, centromere protein A (CENP-A), is essential for epigenetically marking centromere location. We find that CENP-A is quantitatively retained at the centromere upon which it is initially assembled. CENP-C binds to CENP-A nucleosomes and is a prime candidate to stabilize centromeric chromatin. Using purified components, we find that CENP-C reshapes the octameric histone core of CENP-A nucleosomes, rigidifies both surface and internal nucleosome structure, and modulates terminal DNA to match the loose wrap that is found on native CENP-A nucleosomes at functional human centromeres. Thus, CENP-C affects nucleosome shape and dynamics in a manner analogous to allosteric regulation of enzymes. CENP-C depletion leads to rapid removal of CENP-A from centromeres, indicating their collaboration in maintaining centromere identity.

Entities: Chemical Disease Gene Mutation Species

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Year: 2015 PMID： 25954010 PMCID： PMC4610723 DOI： 10.1126/science.1259308

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

16 in total

1. HJURP uses distinct CENP-A surfaces to recognize and to stabilize CENP-A/histone H4 for centromere assembly.

Authors: Emily A Bassett; Jamie DeNizio; Meghan C Barnhart-Dailey; Tanya Panchenko; Nikolina Sekulic; Danielle J Rogers; Daniel R Foltz; Ben E Black
Journal: Dev Cell Date: 2012-03-08 Impact factor: 12.270

2. Crystal structure of the human centromeric nucleosome containing CENP-A.

Authors: Hiroaki Tachiwana; Wataru Kagawa; Tatsuya Shiga; Akihisa Osakabe; Yuta Miya; Kengo Saito; Yoko Hayashi-Takanaka; Takashi Oda; Mamoru Sato; Sam-Yong Park; Hiroshi Kimura; Hitoshi Kurumizaka
Journal: Nature Date: 2011-07-10 Impact factor: 49.962

3. New DNA sequence rules for high affinity binding to histone octamer and sequence-directed nucleosome positioning.

Authors: P T Lowary; J Widom
Journal: J Mol Biol Date: 1998-02-13 Impact factor: 5.469

4. Crystal structure of the nucleosome core particle at 2.8 A resolution.

Authors: K Luger; A W Mäder; R K Richmond; D F Sargent; T J Richmond
Journal: Nature Date: 1997-09-18 Impact factor: 49.962

Review 5. Structure of chromatin.

Authors: R D Kornberg
Journal: Annu Rev Biochem Date: 1977 Impact factor: 23.643

6. The structure of (CENP-A-H4)(2) reveals physical features that mark centromeres.

Authors: Nikolina Sekulic; Emily A Bassett; Danielle J Rogers; Ben E Black
Journal: Nature Date: 2010-08-25 Impact factor: 49.962

7. Structural determinants for generating centromeric chromatin.

Authors: Ben E Black; Daniel R Foltz; Srinivas Chakravarthy; Karolin Luger; Virgil L Woods; Don W Cleveland
Journal: Nature Date: 2004-07-29 Impact factor: 49.962

8. Propagation of centromeric chromatin requires exit from mitosis.

Authors: Lars E T Jansen; Ben E Black; Daniel R Foltz; Don W Cleveland
Journal: J Cell Biol Date: 2007-03-05 Impact factor: 10.539

9. Assembly in G1 phase and long-term stability are unique intrinsic features of CENP-A nucleosomes.

Authors: Dani L Bodor; Luis P Valente; João F Mata; Ben E Black; Lars E T Jansen
Journal: Mol Biol Cell Date: 2013-01-30 Impact factor: 4.138

10. The octamer is the major form of CENP-A nucleosomes at human centromeres.

Authors: Dan Hasson; Tanya Panchenko; Kevan J Salimian; Mishah U Salman; Nikolina Sekulic; Alicia Alonso; Peter E Warburton; Ben E Black
Journal: Nat Struct Mol Biol Date: 2013-05-05 Impact factor: 15.369

91 in total

1. The CENP-L-N Complex Forms a Critical Node in an Integrated Meshwork of Interactions at the Centromere-Kinetochore Interface.

Authors: Kara L McKinley; Nikolina Sekulic; Lucie Y Guo; Tonia Tsinman; Ben E Black; Iain M Cheeseman
Journal: Mol Cell Date: 2015-11-19 Impact factor: 17.970

Chromosomes. CENP-C reshapes and stabilizes CENP-A nucleosomes at the centromere.

1. HJURP uses distinct CENP-A surfaces to recognize and to stabilize CENP-A/histone H4 for centromere assembly.

2. Crystal structure of the human centromeric nucleosome containing CENP-A.

3. New DNA sequence rules for high affinity binding to histone octamer and sequence-directed nucleosome positioning.

4. Crystal structure of the nucleosome core particle at 2.8 A resolution.

Review 5. Structure of chromatin.

6. The structure of (CENP-A-H4)(2) reveals physical features that mark centromeres.

7. Structural determinants for generating centromeric chromatin.

8. Propagation of centromeric chromatin requires exit from mitosis.

9. Assembly in G1 phase and long-term stability are unique intrinsic features of CENP-A nucleosomes.

10. The octamer is the major form of CENP-A nucleosomes at human centromeres.

1. The CENP-L-N Complex Forms a Critical Node in an Integrated Meshwork of Interactions at the Centromere-Kinetochore Interface.

2. Identification of the Post-translational Modifications Present in Centromeric Chromatin.

Review 3. No longer a nuisance: long non-coding RNAs join CENP-A in epigenetic centromere regulation.

Review 4. Touch, act and go: landing and operating on nucleosomes.

Review 5. The right place at the right time: chaperoning core histone variants.

Review 6. The kinetochore interaction network (KIN) of ascomycetes.

7. Structure of the Human Core Centromeric Nucleosome Complex.

8. Distortion of histone octamer core promotes nucleosome mobilization by a chromatin remodeler.

Review 9. Chromatin dynamics during the cell cycle at centromeres.

Review 10. Understanding eukaryotic chromosome segregation from a comparative biology perspective.