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Literature DB >> 26748759

No longer a nuisance: long non-coding RNAs join CENP-A in epigenetic centromere regulation.

Abstract

Centromeres represent the basis for kinetochore formation, and are essential for proper chromosome segregation during mitosis. Despite these essential roles, centromeres are not defined by specific DNA sequences, but by epigenetic means. The histone variant CENP-A controls centromere identity epigenetically and is essential for recruiting kinetochore components that attach the chromosomes to the mitotic spindle during mitosis. Recently, a new player in centromere regulation has emerged: long non-coding RNAs transcribed from repetitive regions of centromeric DNA function in regulating centromeres epigenetically. This review summarizes recent findings on the essential roles that transcription, pericentromeric transcripts, and centromere-derived RNAs play in centromere biology.

Entities: Gene

Keywords: Centromere; Epigenetics; Kinetochore; Long non-coding RNA; Mitosis; Transcription

Mesh：

Substances：

Year: 2016 PMID： 26748759 DOI： 10.1007/s00018-015-2124-7

Source DB: PubMed Journal: Cell Mol Life Sci ISSN： 1420-682X Impact factor: 9.261

105 in total

1. Genomic and genetic definition of a functional human centromere.

Authors: M G Schueler; A W Higgins; M K Rudd; K Gustashaw; H F Willard
Journal: Science Date: 2001-10-05 Impact factor: 47.728

Review 2. Chromosomal dynamics of human neocentromere formation.

Authors: Peter E Warburton
Journal: Chromosome Res Date: 2004 Impact factor: 5.239

Review 3. The role of heterochromatin in centromere function.

Authors: Alison L Pidoux; Robin C Allshire
Journal: Philos Trans R Soc Lond B Biol Sci Date: 2005-03-29 Impact factor: 6.237

4. Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells.

Authors: Hiroshi Izuta; Masashi Ikeno; Nobutaka Suzuki; Takeshi Tomonaga; Naohito Nozaki; Chikashi Obuse; Yasutomo Kisu; Naoki Goshima; Fumio Nomura; Nobuo Nomura; Kinya Yoda
Journal: Genes Cells Date: 2006-06 Impact factor: 1.891

5. The E3 ligase CUL3/RDX controls centromere maintenance by ubiquitylating and stabilizing CENP-A in a CAL1-dependent manner.

Authors: Debora Bade; Anne-Laure Pauleau; Astrid Wendler; Sylvia Erhardt
Journal: Dev Cell Date: 2014-03-10 Impact factor: 12.270

6. Aberrant overexpression of satellite repeats in pancreatic and other epithelial cancers.

Authors: David T Ting; Doron Lipson; Suchismita Paul; Brian W Brannigan; Sara Akhavanfard; Erik J Coffman; Gianmarco Contino; Vikram Deshpande; A John Iafrate; Stan Letovsky; Miguel N Rivera; Nabeel Bardeesy; Shyamala Maheswaran; Daniel A Haber
Journal: Science Date: 2011-01-13 Impact factor: 47.728

7. SUMOylation promotes de novo targeting of HP1α to pericentric heterochromatin.

Authors: Christèle Maison; Delphine Bailly; Danièle Roche; Rocio Montes de Oca; Aline V Probst; Isabelle Vassias; Florent Dingli; Bérengère Lombard; Damarys Loew; Jean-Pierre Quivy; Geneviève Almouzni
Journal: Nat Genet Date: 2011-02-13 Impact factor: 38.330

8. Posttranslational modification of CENP-A influences the conformation of centromeric chromatin.

Authors: Aaron O Bailey; Tanya Panchenko; Kizhakke M Sathyan; Janusz J Petkowski; Pei-Jing Pai; Dina L Bai; David H Russell; Ian G Macara; Jeffrey Shabanowitz; Donald F Hunt; Ben E Black; Daniel R Foltz
Journal: Proc Natl Acad Sci U S A Date: 2013-07-01 Impact factor: 11.205

9. Sequence features and transcriptional stalling within centromere DNA promote establishment of CENP-A chromatin.

Authors: Sandra Catania; Alison L Pidoux; Robin C Allshire
Journal: PLoS Genet Date: 2015-03-04 Impact factor: 5.917

10. The octamer is the major form of CENP-A nucleosomes at human centromeres.

Authors: Dan Hasson; Tanya Panchenko; Kevan J Salimian; Mishah U Salman; Nikolina Sekulic; Alicia Alonso; Peter E Warburton; Ben E Black
Journal: Nat Struct Mol Biol Date: 2013-05-05 Impact factor: 15.369

20 in total

Review 1. Chromatin loops and causality loops: the influence of RNA upon spatial nuclear architecture.

Authors: Iain A Sawyer; Miroslav Dundr
Journal: Chromosoma Date: 2017-06-07 Impact factor: 4.316

Review 2. Transcription of highly repetitive tandemly organized DNA in amphibians and birds: A historical overview and modern concepts.

Authors: Irina Trofimova; Alla Krasikova
Journal: RNA Biol Date: 2016-10-20 Impact factor: 4.652

No longer a nuisance: long non-coding RNAs join CENP-A in epigenetic centromere regulation.

1. Genomic and genetic definition of a functional human centromere.

Review 2. Chromosomal dynamics of human neocentromere formation.

Review 3. The role of heterochromatin in centromere function.

4. Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells.

5. The E3 ligase CUL3/RDX controls centromere maintenance by ubiquitylating and stabilizing CENP-A in a CAL1-dependent manner.

6. Aberrant overexpression of satellite repeats in pancreatic and other epithelial cancers.

7. SUMOylation promotes de novo targeting of HP1α to pericentric heterochromatin.

8. Posttranslational modification of CENP-A influences the conformation of centromeric chromatin.

9. Sequence features and transcriptional stalling within centromere DNA promote establishment of CENP-A chromatin.

10. The octamer is the major form of CENP-A nucleosomes at human centromeres.

Review 1. Chromatin loops and causality loops: the influence of RNA upon spatial nuclear architecture.

Review 2. Transcription of highly repetitive tandemly organized DNA in amphibians and birds: A historical overview and modern concepts.

Review 3. A Matter of Scale and Dimensions: Chromatin of Chromosome Landmarks in the Fungi.

Review 4. Kinetochore assembly and function through the cell cycle.

5. A role of the Trx-G complex in Cid/CENP-A deposition at Drosophila melanogaster centromeres.

6. The Long Intergenic Noncoding RNA (LincRNA) Landscape of the Soybean Genome.

7. Repeat Composition of CenH3-chromatin and H3K9me2-marked heterochromatin in Sugar Beet (Beta vulgaris).

8. Bioinformatics Analysis Reveals Biomarkers With Cancer Stem Cell Characteristics in Lung Squamous Cell Carcinoma.

9. The major horse satellite DNA family is associated with centromere competence.

Review 10. Chromatin assembly: Journey to the CENter of the chromosome.