| Literature DB >> 25950631 |
Juan Carlos Izpisua Belmonte1, Edward M Callaway2, Sarah J Caddick3, Patricia Churchland4, Guoping Feng5, Gregg E Homanics6, Kuo-Fen Lee7, David A Leopold8, Cory T Miller9, Jude F Mitchell10, Shoukhrat Mitalipov11, Alysson R Moutri12, J Anthony Movshon13, Hideyuki Okano14, John H Reynolds15, Dario Ringach16, Terrence J Sejnowski17, Afonso C Silva18, Peter L Strick19, Jun Wu1, Feng Zhang20.
Abstract
One of the great strengths of the mouse model is the wide array of genetic tools that have been developed. Striking examples include methods for directed modification of the genome, and for regulated expression or inactivation of genes. Within neuroscience, it is now routine to express reporter genes, neuronal activity indicators, and opsins in specific neuronal types in the mouse. However, there are considerable anatomical, physiological, cognitive, and behavioral differences between the mouse and the human that, in some areas of inquiry, limit the degree to which insights derived from the mouse can be applied to understanding human neurobiology. Several recent advances have now brought into reach the goal of applying these tools to understanding the primate brain. Here we describe these advances, consider their potential to advance our understanding of the human brain and brain disorders, discuss bioethical considerations, and describe what will be needed to move forward.Entities:
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Year: 2015 PMID： 25950631 PMCID： PMC4425847 DOI： 10.1016/j.neuron.2015.03.021
Source DB: PubMed Journal: Neuron ISSN： 0896-6273 Impact factor: 17.173