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Literature DB >> 26656253

Applications of CRISPR-Cas systems in neuroscience.

Matthias Heidenreich^1,2,3,4, Feng Zhang^1,2,3,4.

Abstract

Genome-editing tools, and in particular those based on CRISPR-Cas (clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR-associated protein) systems, are accelerating the pace of biological research and enabling targeted genetic interrogation in almost any organism and cell type. These tools have opened the door to the development of new model systems for studying the complexity of the nervous system, including animal models and stem cell-derived in vitro models. Precise and efficient gene editing using CRISPR-Cas systems has the potential to advance both basic and translational neuroscience research.

Entities: Chemical Disease Gene Species

Mesh：

Year: 2015 PMID： 26656253 PMCID： PMC4899966 DOI： 10.1038/nrn.2015.2

Source DB: PubMed Journal: Nat Rev Neurosci ISSN： 1471-003X Impact factor: 34.870

120 in total

1. Local gene knockdown in the brain using viral-mediated RNA interference.

Authors: Jonathan D Hommel; Robert M Sears; Dan Georgescu; Diana L Simmons; Ralph J DiLeone
Journal: Nat Med Date: 2003-11-23 Impact factor: 53.440

Review 2. Recombinant adeno-associated viral vectors in the nervous system.

Authors: Corinna Burger; Kevin Nash; Ronald J Mandel
Journal: Hum Gene Ther Date: 2005-07 Impact factor: 5.695

3. Targeted genome modification in mice using zinc-finger nucleases.

Authors: Iara D Carbery; Diana Ji; Anne Harrington; Victoria Brown; Edward J Weinstein; Lucy Liaw; Xiaoxia Cui
Journal: Genetics Date: 2010-07-13 Impact factor: 4.562

4. Targeted genome editing across species using ZFNs and TALENs.

Authors: Andrew J Wood; Te-Wen Lo; Bryan Zeitler; Catherine S Pickle; Edward J Ralston; Andrew H Lee; Rainier Amora; Jeffrey C Miller; Elo Leung; Xiangdong Meng; Lei Zhang; Edward J Rebar; Philip D Gregory; Fyodor D Urnov; Barbara J Meyer
Journal: Science Date: 2011-06-23 Impact factor: 47.728

5. Site-specific recombination determined by I-SceI, a mitochondrial group I intron-encoded endonuclease expressed in the yeast nucleus.

Authors: A Plessis; A Perrin; J E Haber; B Dujon
Journal: Genetics Date: 1992-03 Impact factor: 4.562

6. Modeling familial Alzheimer's disease with induced pluripotent stem cells.

Authors: Takuya Yagi; Daisuke Ito; Yohei Okada; Wado Akamatsu; Yoshihiro Nihei; Takahito Yoshizaki; Shinya Yamanaka; Hideyuki Okano; Norihiro Suzuki
Journal: Hum Mol Genet Date: 2011-09-07 Impact factor: 6.150

7. siRNA-mediated gene silencing in vitro and in vivo.

Authors: Haibin Xia; Qinwen Mao; Henry L Paulson; Beverly L Davidson
Journal: Nat Biotechnol Date: 2002-09-16 Impact factor: 54.908

8. Obligate ligation-gated recombination (ObLiGaRe): custom-designed nuclease-mediated targeted integration through nonhomologous end joining.

Authors: Marcello Maresca; Victor Guosheng Lin; Ning Guo; Yi Yang
Journal: Genome Res Date: 2012-11-14 Impact factor: 9.043

9. Megabase-scale deletion using CRISPR/Cas9 to generate a fully haploid human cell line.

Authors: Patrick Essletzbichler; Tomasz Konopka; Federica Santoro; Doris Chen; Bianca V Gapp; Robert Kralovics; Thijn R Brummelkamp; Sebastian M B Nijman; Tilmann Bürckstümmer
Journal: Genome Res Date: 2014-11-04 Impact factor: 9.043

10. Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system.

Authors: Baohui Chen; Luke A Gilbert; Beth A Cimini; Joerg Schnitzbauer; Wei Zhang; Gene-Wei Li; Jason Park; Elizabeth H Blackburn; Jonathan S Weissman; Lei S Qi; Bo Huang
Journal: Cell Date: 2013-12-19 Impact factor: 41.582

84 in total

Review 1. CRISPR/Cas9, the Powerful New Genome-Editing Tool for Putative Therapeutics in Obesity.

Authors: María José Franco-Tormo; Mireille Salas-Crisostomo; Nuno Barbosa Rocha; Henning Budde; Sérgio Machado; Eric Murillo-Rodríguez
Journal: J Mol Neurosci Date: 2018-05-07 Impact factor: 3.444

Review 2. Gene therapy and genome surgery in the retina.

Authors: James E DiCarlo; Vinit B Mahajan; Stephen H Tsang
Journal: J Clin Invest Date: 2018-06-01 Impact factor: 14.808

3. Experiments in macaque monkeys provide critical insights into age-associated changes in cognitive and sensory function.

Authors: Daniel T Gray; Carol A Barnes
Journal: Proc Natl Acad Sci U S A Date: 2019-12-23 Impact factor: 11.205

Applications of CRISPR-Cas systems in neuroscience.

1. Local gene knockdown in the brain using viral-mediated RNA interference.

Review 2. Recombinant adeno-associated viral vectors in the nervous system.

3. Targeted genome modification in mice using zinc-finger nucleases.

4. Targeted genome editing across species using ZFNs and TALENs.

5. Site-specific recombination determined by I-SceI, a mitochondrial group I intron-encoded endonuclease expressed in the yeast nucleus.

6. Modeling familial Alzheimer's disease with induced pluripotent stem cells.

7. siRNA-mediated gene silencing in vitro and in vivo.

8. Obligate ligation-gated recombination (ObLiGaRe): custom-designed nuclease-mediated targeted integration through nonhomologous end joining.

9. Megabase-scale deletion using CRISPR/Cas9 to generate a fully haploid human cell line.

10. Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system.

Review 1. CRISPR/Cas9, the Powerful New Genome-Editing Tool for Putative Therapeutics in Obesity.

Review 2. Gene therapy and genome surgery in the retina.

3. Experiments in macaque monkeys provide critical insights into age-associated changes in cognitive and sensory function.

4. Legal responses to neuroscience.

5. Why Gene Editors Like CRISPR/Cas May Be a Game-Changer for Neuroweapons.

Review 6. Single-Cell RNA Sequencing: Unraveling the Brain One Cell at a Time.

7. Parkinson's disease: Guilt by genetic association.

Review 8. The cellular mechanisms that maintain neuronal polarity.

Review 9. Molecular tools to elucidate factors regulating alcohol use.

10. Phosphate Lock Residues of Acidothermus cellulolyticus Cas9 Are Critical to Its Substrate Specificity.