Claire Philippat1, Deborah Bennett2, Antonia M Calafat3, Irva Hertz Picciotto4. 1. Department of Public Health Sciences, University of California, Davis, CA, USA; MIND (Medical Investigations of Neurodevelopmental Disorders) Institute, University of California, Davis, CA, USA. Electronic address: cphilippat@ucdavis.edu. 2. Department of Public Health Sciences, University of California, Davis, CA, USA. 3. Centers for Disease Control and Prevention, Atlanta, GA, USA. 4. Department of Public Health Sciences, University of California, Davis, CA, USA; MIND (Medical Investigations of Neurodevelopmental Disorders) Institute, University of California, Davis, CA, USA.
Abstract
INTRODUCTION: Certain phenols and phthalates are used in many consumer products including personal care products (PCPs). AIMS: We aimed to study the associations between the use of PCPs and urinary concentrations of biomarkers of select phenols and phthalates among Californian adults and their children. As an additional aim we compared phenols and phthalate metabolites concentrations measured in adults and children urine samples collected the same day. METHODS: Our study relied on a subsample of 90 adult-child pairs participating in the Study of Use of Products and Exposure Related Behavior (SUPERB). Each adult and child provided one to two urine samples in which we measured concentrations of selected phenols and phthalate metabolites. We computed Spearman correlation coefficients to compare concentrations measured in adults and children urine samples collected the same day. We used adjusted linear and Tobit regression models to study the associations between the use of PCPs in the past 24h and biomarker concentrations. RESULTS: Benzophenone-3 and parabens concentrations were higher in adults compared to their children. Conversely children had higher mono-n-butyl phthalate and mono-isobutyl phthalate concentrations. No significant difference was observed for the other compounds. The total number of different PCPs used was positively associated with urinary concentrations of methyl, propyl and butyl parabens and the main metabolite of diethyl phthalate in adults. Among children, the use of a few specific products including liquid soap, hair care products and sunscreen was positively associated with urinary concentrations of some phenols or phthalate metabolites. DISCUSSION: These results strengthen the body of evidence suggesting that use of PCPs is an important source of exposure to parabens and diethyl phthalate in adults and provide data on exposure to selected phenols and phthalates through use of PCPs in children.
INTRODUCTION: Certain phenols and phthalates are used in many consumer products including personal care products (PCPs). AIMS: We aimed to study the associations between the use of PCPs and urinary concentrations of biomarkers of select phenols and phthalates among Californian adults and their children. As an additional aim we compared phenols and phthalate metabolites concentrations measured in adults and children urine samples collected the same day. METHODS: Our study relied on a subsample of 90 adult-child pairs participating in the Study of Use of Products and Exposure Related Behavior (SUPERB). Each adult and child provided one to two urine samples in which we measured concentrations of selected phenols and phthalate metabolites. We computed Spearman correlation coefficients to compare concentrations measured in adults and children urine samples collected the same day. We used adjusted linear and Tobit regression models to study the associations between the use of PCPs in the past 24h and biomarker concentrations. RESULTS:Benzophenone-3 and parabens concentrations were higher in adults compared to their children. Conversely children had higher mono-n-butyl phthalate and mono-isobutyl phthalate concentrations. No significant difference was observed for the other compounds. The total number of different PCPs used was positively associated with urinary concentrations of methyl, propyl and butyl parabens and the main metabolite of diethyl phthalate in adults. Among children, the use of a few specific products including liquid soap, hair care products and sunscreen was positively associated with urinary concentrations of some phenols or phthalate metabolites. DISCUSSION: These results strengthen the body of evidence suggesting that use of PCPs is an important source of exposure to parabens and diethyl phthalate in adults and provide data on exposure to selected phenols and phthalates through use of PCPs in children.
Authors: Allan C Just; Jennifer J Adibi; Andrew G Rundle; Antonia M Calafat; David E Camann; Russ Hauser; Manori J Silva; Robin M Whyatt Journal: J Expo Sci Environ Epidemiol Date: 2010-03-31 Impact factor: 5.563
Authors: Monika Kasper-Sonnenberg; Holger M Koch; Jürgen Wittsiepe; Michael Wilhelm Journal: Int J Hyg Environ Health Date: 2011-10-07 Impact factor: 5.840
Authors: Tamar Berman; Drorit Hochner-Celnikier; Antonia M Calafat; Larry L Needham; Yona Amitai; Uri Wormser; Elihu Richter Journal: Environ Int Date: 2008-09-27 Impact factor: 9.621
Authors: Sheela Sathyanarayana; Catherine J Karr; Paula Lozano; Elizabeth Brown; Antonia M Calafat; Fan Liu; Shanna H Swan Journal: Pediatrics Date: 2008-02 Impact factor: 7.124
Authors: Robin E Dodson; Marcia Nishioka; Laurel J Standley; Laura J Perovich; Julia Green Brody; Ruthann A Rudel Journal: Environ Health Perspect Date: 2012-03-08 Impact factor: 9.031
Authors: Mary S Wolff; Susan L Teitelbaum; Susan M Pinney; Gayle Windham; Laura Liao; Frank Biro; Lawrence H Kushi; Chris Erdmann; Robert A Hiatt; Michael E Rybak; Antonia M Calafat Journal: Environ Health Perspect Date: 2010-03-22 Impact factor: 9.031
Authors: Dana B Barr; Lynn C Wilder; Samuel P Caudill; Amanda J Gonzalez; Lance L Needham; James L Pirkle Journal: Environ Health Perspect Date: 2005-02 Impact factor: 9.031
Authors: Pahriya Ashrap; Deborah J Watkins; Antonia M Calafat; Xiaoyun Ye; Zaira Rosario; Phil Brown; Carmen M Vélez-Vega; Akram Alshawabkeh; José F Cordero; John D Meeker Journal: Environ Int Date: 2018-10-11 Impact factor: 9.621
Authors: Carmen Messerlian; Vicente Mustieles; Blair J Wylie; Jennifer B Ford; Myra Keller; Xiaoyun Ye; Antonia M Calafat; Paige L Williams; Russ Hauser Journal: Int J Hyg Environ Health Date: 2017-08-14 Impact factor: 5.840
Authors: Iman Al-Saleh; Tahreer Al-Rajudi; Ghofran Al-Qudaihi; Pulicat Manogaran Journal: Environ Sci Pollut Res Int Date: 2017-09-05 Impact factor: 4.223
Authors: Stephanie C Hammel; Jessica L Levasseur; Kate Hoffman; Allison L Phillips; Amelia M Lorenzo; Antonia M Calafat; Thomas F Webster; Heather M Stapleton Journal: Environ Int Date: 2019-08-07 Impact factor: 9.621
Authors: Shaina L Stacy; Melissa Eliot; Taylor Etzel; George Papandonatos; Antonia M Calafat; Aimin Chen; Russ Hauser; Bruce P Lanphear; Sheela Sathyanarayana; Xiaoyun Ye; Kimberly Yolton; Joseph M Braun Journal: Environ Sci Technol Date: 2017-05-25 Impact factor: 9.028