Literature DB >> 25920807

Genetic variants within the serotonin transporter associated with familial risk for major depression.

Ardesheer Talati1, Guia Guffanti2, Zagaa Odgerel3, Iuliana Ionita-Laza4, Heli Malm5, Andre Sourander6, Alan S Brown7, Priya J Wickramaratne8, Jay A Gingrich9, Myrna M Weissman10.   

Abstract

The role of the serotonin transporter promoter linked polymorphism (5HTTLPR) in depression, despite much research, remains unclear. Most studies compare persons with and without depression to each other. We show offspring at high (N = 192) as compared to low (N = 101) familial risk for major depressive disorder were almost four times as likely to have two copies of the short allele at 5HTTLPR, suggesting that incorporation of family history could be helpful in identifying genetic differences.
Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Entities:  

Keywords:  High-risk design; Serotonin transporter linked polymorphic region (5HTTLPR); rs25531

Mesh：

Substances：

Year:  2015        PMID： 25920807      PMCID： PMC4451257          DOI： 10.1016/j.psychres.2015.04.015

Source DB:  PubMed          Journal:  Psychiatry Res        ISSN： 0165-1781            Impact factor:   3.222


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