Aanand D Naik1, Natalie Uy2, Daniel A Anaya3, Jennifer Moye4. 1. Houston VA HSR&D Center for Innovations in Quality, Effectiveness and Safety, Michael E. DeBakey VA Medical Center (MEDVAMC 152), 2002 Holcombe Blvd., Houston, TX 77030, USA; Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA. Electronic address: anaik@bcm.edu. 2. Houston VA HSR&D Center for Innovations in Quality, Effectiveness and Safety, Michael E. DeBakey VA Medical Center (MEDVAMC 152), 2002 Holcombe Blvd., Houston, TX 77030, USA; Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA. Electronic address: Natalie.Uy@bcm.edu. 3. Houston VA HSR&D Center for Innovations in Quality, Effectiveness and Safety, Michael E. DeBakey VA Medical Center (MEDVAMC 152), 2002 Holcombe Blvd., Houston, TX 77030, USA; Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA. Electronic address: Daniel.anaya@va.gov. 4. Geriatric Mental Health, VA Boston Healthcare System, Brockton Division, 940 Belmont St., Brockton, MA 02301, USA; Harvard Medical School, 25 Shattuck St., Boston, MA 02115, USA. Electronic address: Jennifer.Moye@va.gov.
Abstract
OBJECTIVE: Less is known about longitudinal changes in quality of life between treatment completion and early survivorship among multimorbid cancer survivors. The current study describes longitudinal changes in quality of life among a multimorbid cohort of US Veterans diagnosed and treated for colorectal cancer. MATERIALS AND METHODS: A sample of 68 multimorbid adults with colon and/or rectal cancer who received one or more treatment options (surgery, chemo or radiation therapy) was recruited. Participants were not excluded by cancer stage unless they reported being in hospice or similar status. Comprehensive assessments of quality of life and treatment side-effects were conducted 6, 12, and 18months after diagnosis. Descriptive statistics characterized treatment side-effects and changes in quality-of-life domains longitudinally. Multivariate Analysis of Variance identified sociodemographic and clinical variables associated with quality of life changes. RESULTS: Many physical symptoms improved from 6 to 18months following diagnosis, while some remained stable. Sexual symptoms worsened, attributable to increasing rates of dysfunction in older patients. Low education attainment was predictive of worse physical symptoms (F=5.59, p=.023) and associated with body concerns (F=5.7; p=.005) over time. Advanced cancer stage (F=4.94; p<.04) and receipt of chemotherapy (F=4.21; p<.05) independently predicted body concerns in multivariate analyses. CONCLUSION: Endorsement of physical and sexual symptoms and body concerns occurs in different patterns over time among multimorbid colorectal cancer survivors. Low education attainment is consistently associated with physical symptoms and body concerns. Cancer stage and chemotherapy are predictive of body concerns, but not physical or sexual symptoms. Published by Elsevier Ltd.
OBJECTIVE: Less is known about longitudinal changes in quality of life between treatment completion and early survivorship among multimorbid cancer survivors. The current study describes longitudinal changes in quality of life among a multimorbid cohort of US Veterans diagnosed and treated for colorectal cancer. MATERIALS AND METHODS: A sample of 68 multimorbid adults with colon and/or rectal cancer who received one or more treatment options (surgery, chemo or radiation therapy) was recruited. Participants were not excluded by cancer stage unless they reported being in hospice or similar status. Comprehensive assessments of quality of life and treatment side-effects were conducted 6, 12, and 18months after diagnosis. Descriptive statistics characterized treatment side-effects and changes in quality-of-life domains longitudinally. Multivariate Analysis of Variance identified sociodemographic and clinical variables associated with quality of life changes. RESULTS: Many physical symptoms improved from 6 to 18months following diagnosis, while some remained stable. Sexual symptoms worsened, attributable to increasing rates of dysfunction in older patients. Low education attainment was predictive of worse physical symptoms (F=5.59, p=.023) and associated with body concerns (F=5.7; p=.005) over time. Advanced cancer stage (F=4.94; p<.04) and receipt of chemotherapy (F=4.21; p<.05) independently predicted body concerns in multivariate analyses. CONCLUSION: Endorsement of physical and sexual symptoms and body concerns occurs in different patterns over time among multimorbid colorectal cancer survivors. Low education attainment is consistently associated with physical symptoms and body concerns. Cancer stage and chemotherapy are predictive of body concerns, but not physical or sexual symptoms. Published by Elsevier Ltd.
Entities:
Keywords:
Cancer survivors; Colorectal cancer; Multimorbidity; Quality of life; Symptoms
Authors: Faisal N Cheema; Neena S Abraham; David H Berger; Daniel Albo; George E Taffet; Aanand D Naik Journal: Ann Surg Date: 2011-05 Impact factor: 12.969
Authors: Jesus Hermosillo-Rodriguez; Daniel A Anaya; Yvonne Sada; Annette Walder; Amber B Amspoker; David H Berger; Aanand D Naik Journal: J Geriatr Oncol Date: 2013-01-12 Impact factor: 3.599
Authors: Carey A Gall; David Weller; Adrian Esterman; Louis Pilotto; Kelly McGorm; Zoe Hammett; David Wattchow Journal: Dis Colon Rectum Date: 2007-06 Impact factor: 4.585
Authors: Ulrike Boehmer; Jennifer Potter; Melissa A Clark; Al Ozonoff; Michael Winter; Flora Berklein; Kevin C Ward; Kevan Hartshorn Journal: Support Care Cancer Date: 2021-03-19 Impact factor: 3.359
Authors: Ulrike Boehmer; Al Ozonoff; Michael Winter; Flora Berklein; Jennifer Potter; Kevan L Hartshorn; Kevin C Ward; Rachel M Ceballos; Melissa A Clark Journal: Cancer Date: 2021-07-08 Impact factor: 6.921
Authors: Claire O'Gorman; Jim Stack; Alan O'Ceilleachair; Suzanne Denieffe; Martina Gooney; Martina McKnight; Linda Sharp Journal: BMC Cancer Date: 2018-10-22 Impact factor: 4.430