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Literature DB >> 25920443

2015 Guidelines for Establishing Genetically Modified Rat Models for Cardiovascular Research.

Michael J Flister¹, Jeremy W Prokop, Jozef Lazar, Mary Shimoyama, Melinda Dwinell, Aron Geurts.

Abstract

The rat has long been a key physiological model for cardiovascular research, most of the inbred strains having been previously selected for susceptibility or resistance to various cardiovascular diseases (CVD). These CVD rat models offer a physiologically relevant background on which candidates of human CVD can be tested in a more clinically translatable experimental setting. However, a diverse toolbox for genetically modifying the rat genome to test molecular mechanisms has only recently become available. Here, we provide a high-level description of several strategies for developing genetically modified rat models of CVD.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Substances：
Genetic Markers

Year: 2015 PMID： 25920443 PMCID： PMC4475456 DOI： 10.1007/s12265-015-9626-4

Source DB: PubMed Journal: J Cardiovasc Transl Res ISSN： 1937-5387 Impact factor: 4.132

75 in total

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