OBJECTIVE: Diffusion-weighted imaging (DWI) provides essential information regarding tumor composition, such as cellularity and/or perfusion. DWI is helpful in distinguishing between malignant and benign lesions. Malignant intramuscular/soft tissue lesions consist of a wide spectrum of tumors that have different cell counts and matrix. It is presumed that these different tumors have different DWI findings and have different apparent diffusion coefficient (ADC) values. The aim of this study was to analyze DWI findings of different intramuscular malignancies in a multicentric study by using a standardized DWI protocol, and to compare the ADC values acquired. MATERIALS AND METHODS: The data banks of four radiology departments were screened retrospectively for malignant intramuscular tumors. Only lesions that were investigated by MRI (with a 1.5-T scanner) using DWI (multishot EPI sequence with b values of 0 and 1,000 s/mm(2)) were included in the study. Overall, 51 patients (28 women, 23 men; mean age 58.8 ± 16.1 years) with 57 different malignant intramuscular lesions were collected. In every case apparent diffusion constant (ADC) maps were calculated. In 14 patients muscle lymphoma, 11 patients intramuscular metastases from different primary tumors, and in 26 cases several muscle sarcomas were identified. RESULTS: The mean ADC value of the estimated lesions was 1.24 ± 0.53 × 10(-3) mm(2)s(-1), median value, 1.11 × 10(-3) mm(2)s(-1), range, 0.54-2.9 × 10(-3) mm(2)s(-1). The mean ADC value in muscle metastases was 1.28 ± 0.24 × 10(-3) mm(2)s(-1), in muscle lymphoma 0.76 ± 0.14 × 10(-3) mm(2)s(-1), and in muscle sarcomas 1.82 ± 0.63 × 10(-3) mm(2)s(-1). Muscle lymphoma showed statistically significant lower ADC values in comparison to muscle metastases (p = 0.01) and muscle sarcoma (p = 0.001). There was no significant differences between ADC values in muscle metastases and sarcomas (p = 0.48). ADC values in muscle lymphoma were homogeneous with less inter-patient variability and were within a relatively close range. Muscle sarcomas had a broad range of ADC values. CONCLUSION: Intramuscular malignant lesions had different ADC values on DWI. 22.8% of the tumors analyzed had low ADC values, 26.3% moderate, and 50.9% high ADC values. Muscle lymphoma had statistically significantly lower ADC values in comparison to muscle metastases and sarcomas. Muscle sarcomas presented with a broad range of ADC values.
OBJECTIVE: Diffusion-weighted imaging (DWI) provides essential information regarding tumor composition, such as cellularity and/or perfusion. DWI is helpful in distinguishing between malignant and benign lesions. Malignant intramuscular/soft tissue lesions consist of a wide spectrum of tumors that have different cell counts and matrix. It is presumed that these different tumors have different DWI findings and have different apparent diffusion coefficient (ADC) values. The aim of this study was to analyze DWI findings of different intramuscular malignancies in a multicentric study by using a standardized DWI protocol, and to compare the ADC values acquired. MATERIALS AND METHODS: The data banks of four radiology departments were screened retrospectively for malignant intramuscular tumors. Only lesions that were investigated by MRI (with a 1.5-T scanner) using DWI (multishot EPI sequence with b values of 0 and 1,000 s/mm(2)) were included in the study. Overall, 51 patients (28 women, 23 men; mean age 58.8 ± 16.1 years) with 57 different malignant intramuscular lesions were collected. In every case apparent diffusion constant (ADC) maps were calculated. In 14 patientsmuscle lymphoma, 11 patients intramuscular metastases from different primary tumors, and in 26 cases several muscle sarcomas were identified. RESULTS: The mean ADC value of the estimated lesions was 1.24 ± 0.53 × 10(-3) mm(2)s(-1), median value, 1.11 × 10(-3) mm(2)s(-1), range, 0.54-2.9 × 10(-3) mm(2)s(-1). The mean ADC value in muscle metastases was 1.28 ± 0.24 × 10(-3) mm(2)s(-1), in muscle lymphoma 0.76 ± 0.14 × 10(-3) mm(2)s(-1), and in muscle sarcomas 1.82 ± 0.63 × 10(-3) mm(2)s(-1). Muscle lymphoma showed statistically significant lower ADC values in comparison to muscle metastases (p = 0.01) and muscle sarcoma (p = 0.001). There was no significant differences between ADC values in muscle metastases and sarcomas (p = 0.48). ADC values in muscle lymphoma were homogeneous with less inter-patient variability and were within a relatively close range. Muscle sarcomas had a broad range of ADC values. CONCLUSION: Intramuscular malignant lesions had different ADC values on DWI. 22.8% of the tumors analyzed had low ADC values, 26.3% moderate, and 50.9% high ADC values. Muscle lymphoma had statistically significantly lower ADC values in comparison to muscle metastases and sarcomas. Muscle sarcomas presented with a broad range of ADC values.
Authors: Juliette P Driessen; Joana Caldas-Magalhaes; Luuk M Janssen; Frank A Pameijer; Nina Kooij; Chris H J Terhaard; Wilko Grolman; Marielle E P Philippens Journal: Radiology Date: 2014-04-17 Impact factor: 11.105
Authors: Amalia Lupi; Michael Weber; Paolo Del Fiore; Marco Rastrelli; Giuseppe Guglielmi; Roberto Stramare; Emilio Quaia; Diego Cecchin; Chiara Giraudo Journal: Eur Radiol Date: 2019-12-13 Impact factor: 5.315
Authors: N M deSouza; J M Winfield; J C Waterton; A Weller; M-V Papoutsaki; S J Doran; D J Collins; L Fournier; D Sullivan; T Chenevert; A Jackson; M Boss; S Trattnig; Y Liu Journal: Eur Radiol Date: 2017-09-27 Impact factor: 5.315
Authors: Eugenio Rimondi; Maria Serena Benassi; Alberto Bazzocchi; Alba Balladelli; Giancarlo Facchini; Giuseppe Rossi; Sophie Taieb; Daniel Vanel Journal: Cancer Imaging Date: 2016-06-07 Impact factor: 3.909