Lingtak-Neander Chan1,2, Charlotte H Neilson3, Elizabeth A Kirk3, Tiana F Colovos4,3,5, Diane R Javelli4,3,5, Saurabh Khandelwal6. 1. Department of Pharmacy, School of Pharmacy, University of Washington, 1959 NE Pacific Street, Box 357630, Seattle, WA, 98195, USA. neander@u.washington.edu. 2. Graduate Program in Nutritional Sciences, School of Public Health, Seattle, WA, USA. neander@u.washington.edu. 3. Graduate Program in Nutritional Sciences, School of Public Health, Seattle, WA, USA. 4. Department of Pharmacy, School of Pharmacy, University of Washington, 1959 NE Pacific Street, Box 357630, Seattle, WA, 98195, USA. 5. Department of Nutritional Services, University of Washington Medical Center, Seattle, WA, USA. 6. Department of Surgery, School of Medicine, University of Washington, Seattle, WA, USA.
Abstract
BACKGROUND: Patients who undergo bariatric surgery are at risk for micronutrient deficiencies. The aims of this study were to determine the prevalence and predictors of vitamin D deficiency in obese patients residing in the northern climate, and to evaluate the effectiveness of a daily maintenance dose of vitamin D 2000 IU in preventing hypovitaminosis D within 1 year after bariatric surgery. METHODS: A cohort study involving adult patients undergoing RYGB was conducted. Longitudinal changes in serum vitamin D concentrations and clinical parameters were measured and collected. RESULTS: Data from 134 recipients of RYGB were analyzed. Hypovitaminosis D was identified in 86 patients (64 %), and was significantly affected by seasonal change and the number of comorbidities. Follow-up data were available in 60 patients. Vitamin D sufficiency was achieved in 62.5 % of those patients with baseline vitamin D insufficiency. A dose-response relationship of vitamin D intake was observed, with the most significant increase in 25(OH)D associated with daily vitamin D intakes ≥ 2000 IU. CONCLUSIONS: The prevalence of hypovitaminosis D before RYGB was comparable to patients living in the non-northern climate. Daily vitamin D intake meeting at least 2000 IU is associated with greater improvement in serum vitamin D concentration.
BACKGROUND:Patients who undergo bariatric surgery are at risk for micronutrient deficiencies. The aims of this study were to determine the prevalence and predictors of vitamin D deficiency in obesepatients residing in the northern climate, and to evaluate the effectiveness of a daily maintenance dose of vitamin D 2000 IU in preventing hypovitaminosis D within 1 year after bariatric surgery. METHODS: A cohort study involving adult patients undergoing RYGB was conducted. Longitudinal changes in serum vitamin D concentrations and clinical parameters were measured and collected. RESULTS: Data from 134 recipients of RYGB were analyzed. Hypovitaminosis D was identified in 86 patients (64 %), and was significantly affected by seasonal change and the number of comorbidities. Follow-up data were available in 60 patients. Vitamin D sufficiency was achieved in 62.5 % of those patients with baseline vitamin Dinsufficiency. A dose-response relationship of vitamin D intake was observed, with the most significant increase in 25(OH)D associated with daily vitamin D intakes ≥ 2000 IU. CONCLUSIONS: The prevalence of hypovitaminosis D before RYGB was comparable to patients living in the non-northern climate. Daily vitamin D intake meeting at least 2000 IU is associated with greater improvement in serum vitamin D concentration.
Entities:
Keywords:
Bariatric surgery; Northern climate; Roux-en-Y gastric bypass; Vitamin D
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