Literature DB >> 25907221

Examining the utility of patient-derived xenograft mouse models.

Samuel Aparicio1, Manuel Hidalgo2, Andrew L Kung3.   

Abstract

Patient-derived xenograft (PDX) models are now being widely used in cancer research and have the potential to greatly inform our understanding of cancer biology. However, many questions remain, especially regarding the ability of PDX models to affect clinical decision making. With these points in mind, we asked three scientists to give their opinions on the generation and uses of PDX models and the future of this field.

Entities:  

Mesh：

Year:  2015        PMID： 25907221     DOI： 10.1038/nrc3944

Source DB:  PubMed          Journal:  Nat Rev Cancer        ISSN： 1474-175X            Impact factor:   60.716


  42 in total

1.  Prioritizing phase I treatment options through preclinical testing on personalized tumorgraft.

Authors:  M Pia Morelli; Emiliano Calvo; Esther Ordoñez; Michael J Wick; Belen-Rubio Viqueira; Pedro P Lopez-Casas; Elizabeth Bruckheimer; Antonio Calles-Blanco; David Sidransky; Manuel Hidalgo
Journal:  J Clin Oncol       Date:  2011-12-19       Impact factor: 44.544

2.  A model for personalized in vivo analysis of human immune responsiveness.

Authors:  Hannes Kalscheuer; Nichole Danzl; Takashi Onoe; Ted Faust; Robert Winchester; Robin Goland; Ellen Greenberg; Thomas R Spitzer; David G Savage; Hiroyuki Tahara; Goda Choi; Yong-Guang Yang; Megan Sykes
Journal:  Sci Transl Med       Date:  2012-03-14       Impact factor: 17.956

3.  Preclinical testing of antileukemic drugs using an in vivo model of systemic disease.

Authors:  Richard B Lock; Natalia L Liem; Rachael A Papa
Journal:  Methods Mol Med       Date:  2005

4.  Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution.

Authors:  Peter Eirew; Adi Steif; Jaswinder Khattra; Gavin Ha; Damian Yap; Hossein Farahani; Karen Gelmon; Stephen Chia; Colin Mar; Adrian Wan; Emma Laks; Justina Biele; Karey Shumansky; Jamie Rosner; Andrew McPherson; Cydney Nielsen; Andrew J L Roth; Calvin Lefebvre; Ali Bashashati; Camila de Souza; Celia Siu; Radhouane Aniba; Jazmine Brimhall; Arusha Oloumi; Tomo Osako; Alejandra Bruna; Jose L Sandoval; Teresa Algara; Wendy Greenwood; Kaston Leung; Hongwei Cheng; Hui Xue; Yuzhuo Wang; Dong Lin; Andrew J Mungall; Richard Moore; Yongjun Zhao; Julie Lorette; Long Nguyen; David Huntsman; Connie J Eaves; Carl Hansen; Marco A Marra; Carlos Caldas; Sohrab P Shah; Samuel Aparicio
Journal:  Nature       Date:  2014-11-26       Impact factor: 49.962

5.  Establishment of patient-derived non-small cell lung cancer xenografts as models for the identification of predictive biomarkers.

Authors:  Iduna Fichtner; Jana Rolff; Richie Soong; Jens Hoffmann; Stefanie Hammer; Anette Sommer; Michael Becker; Johannes Merk
Journal:  Clin Cancer Res       Date:  2008-10-15       Impact factor: 12.531

6.  A renewable tissue resource of phenotypically stable, biologically and ethnically diverse, patient-derived human breast cancer xenograft models.

Authors:  Xiaomei Zhang; Sofie Claerhout; Aleix Prat; Lacey E Dobrolecki; Ivana Petrovic; Qing Lai; Melissa D Landis; Lisa Wiechmann; Rachel Schiff; Mario Giuliano; Helen Wong; Suzanne W Fuqua; Alejandro Contreras; Carolina Gutierrez; Jian Huang; Sufeng Mao; Anne C Pavlick; Amber M Froehlich; Meng-Fen Wu; Anna Tsimelzon; Susan G Hilsenbeck; Edward S Chen; Pavel Zuloaga; Chad A Shaw; Mothaffar F Rimawi; Charles M Perou; Gordon B Mills; Jenny C Chang; Michael T Lewis
Journal:  Cancer Res       Date:  2013-06-04       Impact factor: 12.701

7.  Orthotopic transplantation models of pancreatic adenocarcinoma derived from cell lines and primary tumors and displaying varying metastatic activity.

Authors:  Panayiotis Loukopoulos; Kengo Kanetaka; Masaaki Takamura; Tatsuhiro Shibata; Michiie Sakamoto; Setsuo Hirohashi
Journal:  Pancreas       Date:  2004-10       Impact factor: 3.327

8.  A new model of patient tumor-derived breast cancer xenografts for preclinical assays.

Authors:  Elisabetta Marangoni; Anne Vincent-Salomon; Nathalie Auger; Armelle Degeorges; Franck Assayag; Patricia de Cremoux; Ludmilla de Plater; Charlotte Guyader; Gonzague De Pinieux; Jean-Gabriel Judde; Magali Rebucci; Carine Tran-Perennou; Xavier Sastre-Garau; Brigitte Sigal-Zafrani; Olivier Delattre; Véronique Diéras; Marie-France Poupon
Journal:  Clin Cancer Res       Date:  2007-07-01       Impact factor: 12.531

9.  Stromal disrupting effects of nab-paclitaxel in pancreatic cancer.

Authors:  R Alvarez; M Musteanu; E Garcia-Garcia; P P Lopez-Casas; D Megias; C Guerra; M Muñoz; Y Quijano; A Cubillo; J Rodriguez-Pascual; C Plaza; E de Vicente; S Prados; S Tabernero; M Barbacid; F Lopez-Rios; M Hidalgo
Journal:  Br J Cancer       Date:  2013-08-01       Impact factor: 7.640

10.  Transcriptional dissection of pancreatic tumors engrafted in mice.

Authors:  Raquel Martinez-Garcia; David Juan; Antonio Rausell; Manuel Muñoz; Natalia Baños; Camino Menéndez; Pedro P Lopez-Casas; Daniel Rico; Alfonso Valencia; Manuel Hidalgo
Journal:  Genome Med       Date:  2014-04-16       Impact factor: 11.117
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  142 in total

Review 1.  Colorectal cancer models for novel drug discovery.

Authors:  Daniel Golovko; Dmitriy Kedrin; Ömer H Yilmaz; Jatin Roper
Journal:  Expert Opin Drug Discov       Date:  2015-08-21       Impact factor: 6.098

2.  Sacrificial Bioprinting of a Mammary Ductal Carcinoma Model.

Authors:  Margaux Duchamp; Tingting Liu; Anne M van Genderen; Vanessa Kappings; Rahmi Oklu; Leif W Ellisen; Yu Shrike Zhang
Journal:  Biotechnol J       Date:  2019-05-27       Impact factor: 4.677

3.  Anti-VEGFR2 driven nuclear translocation of VEGFR2 and acquired malignant hallmarks are mutation dependent in glioblastoma.

Authors:  Adarsh Shankar; Meenu Jain; Mei Jing Lim; Kartik Angara; Peng Zeng; Syed A Arbab; Asm Iskander; Roxan Ara; Ali S Arbab; Bhagelu R Achyut
Journal:  J Cancer Sci Ther       Date:  2016-07-15

4.  DNA methyltransferase expression in triple-negative breast cancer predicts sensitivity to decitabine.

Authors:  Jia Yu; Bo Qin; Ann M Moyer; Somaira Nowsheen; Tongzheng Liu; Sisi Qin; Yongxian Zhuang; Duan Liu; Shijia W Lu; Krishna R Kalari; Daniel W Visscher; John A Copland; Sarah A McLaughlin; Alvaro Moreno-Aspitia; Donald W Northfelt; Richard J Gray; Zhenkun Lou; Vera J Suman; Richard Weinshilboum; Judy C Boughey; Matthew P Goetz; Liewei Wang
Journal:  J Clin Invest       Date:  2018-04-30       Impact factor: 14.808

Review 5.  Heralding a new paradigm in 3D tumor modeling.

Authors:  Eliza L S Fong; Daniel A Harrington; Mary C Farach-Carson; Hanry Yu
Journal:  Biomaterials       Date:  2016-09-02       Impact factor: 12.479

6.  Immunotherapy response modeling by ex-vivo organ culture for lung cancer.

Authors:  Iris Kamer; Elizabeta Bab-Dinitz; Oranit Zadok; Efrat Ofek; Teodor Gottfried; Inbal Daniel-Meshulam; Goni Hout-Siloni; Alon Ben Nun; Iris Barshack; Amir Onn; Jair Bar
Journal:  Cancer Immunol Immunother       Date:  2021-01-23       Impact factor: 6.968

Review 7.  Intestinal Organoids: New Frontiers in the Study of Intestinal Disease and Physiology.

Authors:  Thomas E Wallach; James R Bayrer
Journal:  J Pediatr Gastroenterol Nutr       Date:  2017-02       Impact factor: 2.839

Review 8.  Development of Preclinical Models to Understand and Treat Colorectal Cancer.

Authors:  Judith S Sebolt-Leopold
Journal:  Clin Colon Rectal Surg       Date:  2018-04-01

9.  A Plug-and-Play, Drug-on-Pillar Platform for Combination Drug Screening Implemented by Microfluidic Adaptive Printing.

Authors:  Jiannan Li; Wen Tan; Wenwu Xiao; Randy P Carney; Yongfan Men; Yuanpei Li; Gerald Quon; Yousif Ajena; Kit S Lam; Tingrui Pan
Journal:  Anal Chem       Date:  2018-11-13       Impact factor: 6.986

10.  Modified breast cancer model for preclinical immunotherapy studies.

Authors:  Eriko Katsuta; Stephanie C DeMasi; Krista P Terracina; Sarah Spiegel; Giao Q Phan; Harry D Bear; Kazuaki Takabe
Journal:  J Surg Res       Date:  2016-06-08       Impact factor: 2.192
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