Literature DB >> 25906795

Incision and stress regulation in borderline personality disorder: neurobiological mechanisms of self-injurious behaviour.

Sarah Reitz1, Rosemarie Kluetsch1, Inga Niedtfeld1, Teresa Knorz1, Stefanie Lis1, Christian Paret1, Peter Kirsch1, Andreas Meyer-Lindenberg1, Rolf-Detlef Treede1, Ulf Baumgärtner1, Martin Bohus1, Christian Schmahl2.   

Abstract

BACKGROUND: Patients with borderline personality disorder frequently show non-suicidal self-injury (NSSI). In these patients, NSSI often serves to reduce high levels of stress. AIMS: Investigation of neurobiological mechanisms of NSSI in borderline personality disorder.
METHOD: In total, 21 women with borderline personality disorder and 17 healthy controls underwent a stress induction, followed by either an incision into the forearm or a sham treatment. Afterwards participants underwent resting-state functional magnetic resonance imaging while aversive tension, heart rate and heart rate variability were assessed.
RESULTS: We found a significant influence of incision on subjective and objective stress levels with a stronger decrease of aversive tension in the borderline personality disorder group following incision than sham. Amygdala activity decreased more and functional connectivity with superior frontal gyrus normalised after incision in the borderline personality disorder group.
CONCLUSIONS: Decreased stress levels and amygdala activity after incision support the assumption of an influence of NSSI on emotion regulation in individuals with borderline personality disorder and aids in understanding why these patients use self-inflicted pain to reduce inner tension. © The Royal College of Psychiatrists 2015.

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Year:  2015        PMID: 25906795     DOI: 10.1192/bjp.bp.114.153379

Source DB:  PubMed          Journal:  Br J Psychiatry        ISSN: 0007-1250            Impact factor:   9.319


  27 in total

1.  Assessing Non-Suicidal Self-Injury in the Laboratory.

Authors:  Brooke A Ammerman; Mitchell E Berman; Michael S McCloskey
Journal:  Arch Suicide Res       Date:  2017-06-05

2.  Multi-modal neuroimaging of adolescents with non-suicidal self-injury: Amygdala functional connectivity.

Authors:  Melinda Westlund Schreiner; Bonnie Klimes-Dougan; Bryon A Mueller; Lynn E Eberly; Kristina M Reigstad; Patricia A Carstedt; Kathleen M Thomas; Ruskin H Hunt; Kelvin O Lim; Kathryn R Cullen
Journal:  J Affect Disord       Date:  2017-06-13       Impact factor: 4.839

Review 3.  Toward an animal model of borderline personality disorder.

Authors:  M B Corniquel; H W Koenigsberg; E Likhtik
Journal:  Psychopharmacology (Berl)       Date:  2019-06-15       Impact factor: 4.530

4.  Exploring the links among borderline personality disorder symptoms, trauma, and pain in patients with chronic pain disorders.

Authors:  Benjamin N Johnson; Mark A Lumley; Jennifer S Cheavens; Lindsey C McKernan
Journal:  J Psychosom Res       Date:  2020-06-01       Impact factor: 3.006

Review 5.  Conceptualizing the neurobiology of non-suicidal self-injury from the perspective of the Research Domain Criteria Project.

Authors:  Melinda Westlund Schreiner; Bonnie Klimes-Dougan; Erin D Begnel; Kathryn R Cullen
Journal:  Neurosci Biobehav Rev       Date:  2015-09-28       Impact factor: 8.989

6.  Neural reward responsiveness in children who engage in nonsuicidal self-injury: an ERP study.

Authors:  Aliona Tsypes; Max Owens; Greg Hajcak; Brandon E Gibb
Journal:  J Child Psychol Psychiatry       Date:  2018-04-17       Impact factor: 8.982

7.  Predicting Non-Suicidal Self-Injury in Young Adults with and without Borderline Personality Disorder: a Multilevel Approach Combining Ecological Momentary Assessment and Self-Report Measures.

Authors:  Laia Briones-Buixassa; Ítalo Alí; Carlos Schmidt; Stella Nicolaou; Juan Carlos Pascual; Joaquim Soler; Daniel Vega
Journal:  Psychiatr Q       Date:  2021-01-21

8.  Potential Mood Variation Following a Behavioral Analogue of Self-Injurious Behavior.

Authors:  Brooke A Ammerman; Kristen M Sorgi; Mitchell E Berman; Emil F Coccaro; Michael S McCloskey
Journal:  Arch Suicide Res       Date:  2018-11-22

Review 9.  [Neurobiological principles of borderline personality disorder: integration into the ICD-11 model of personality disorders].

Authors:  Katja Bertsch; Sabine C Herpertz
Journal:  Nervenarzt       Date:  2021-05-21       Impact factor: 1.214

Review 10.  Cognition in the Chronic Pain Experience: Preclinical Insights.

Authors:  Caroline E Phelps; Edita Navratilova; Frank Porreca
Journal:  Trends Cogn Sci       Date:  2021-01-25       Impact factor: 20.229

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