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Literature DB >> 25901318

Functional and mechanistic studies of XPC DNA-repair complex as transcriptional coactivator in embryonic stem cells.

Claudia Cattoglio¹, Elisa T Zhang¹, Ivan Grubisic², Kunitoshi Chiba¹, Yick W Fong³, Robert Tjian⁴.

Abstract

The embryonic stem cell (ESC) state is transcriptionally controlled by OCT4, SOX2, and NANOG with cofactors, chromatin regulators, noncoding RNAs, and other effectors of signaling pathways. Uncovering components of these regulatory circuits and their interplay provides the knowledge base to deploy ESCs and induced pluripotent stem cells. We recently identified the DNA-repair complex xeroderma pigmentosum C (XPC)-RAD23B-CETN2 as a stem cell coactivator (SCC) required for OCT4/SOX2 transcriptional activation. Here we investigate the role of SCC genome-wide in murine ESCs by mapping regions bound by RAD23B and analyzing transcriptional profiles of SCC-depleted ESCs. We establish OCT4 and SOX2 as the primary transcription factors recruiting SCC to regulatory regions of pluripotency genes and identify the XPC subunit as essential for interaction with the two proteins. The present study reveals new mechanistic and functional aspects of SCC transcriptional activity, and thus underscores the diversified functions of this regulatory complex.

Entities: Disease Gene Species

Keywords: ChIP-seq; RNA-seq; pluripotency; protein–protein interactions; transcription

Mesh：

Substances：

Year: 2015 PMID： 25901318 PMCID： PMC4426448 DOI： 10.1073/pnas.1505569112

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

73 in total

1. Centrin 2 stimulates nucleotide excision repair by interacting with xeroderma pigmentosum group C protein.

Authors: Ryotaro Nishi; Yuki Okuda; Eriko Watanabe; Toshio Mori; Shigenori Iwai; Chikahide Masutani; Kaoru Sugasawa; Fumio Hanaoka
Journal: Mol Cell Biol Date: 2005-07 Impact factor: 4.272

Review 2. The ubiquitin receptor Rad23: at the crossroads of nucleotide excision repair and proteasomal degradation.

Authors: Nico P Dantuma; Christian Heinen; Deborah Hoogstraten
Journal: DNA Repair (Amst) Date: 2009-02-14

3. A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity.

Authors: Li Ding; Maciej Paszkowski-Rogacz; Anja Nitzsche; Mikolaj Michal Slabicki; Anne-Kristin Heninger; Ingrid de Vries; Ralf Kittler; Magno Junqueira; Andrej Shevchenko; Herbert Schulz; Norbert Hubner; Michael Xavier Doss; Agapios Sachinidis; Juergen Hescheler; Roberto Iacone; Konstantinos Anastassiadis; A Francis Stewart; M Teresa Pisabarro; Antonio Caldarelli; Ina Poser; Mirko Theis; Frank Buchholz
Journal: Cell Stem Cell Date: 2009-04-02 Impact factor: 24.633

4. Control of embryonic stem cell lineage commitment by core promoter factor, TAF3.

Authors: Zhe Liu; Devin R Scannell; Michael B Eisen; Robert Tjian
Journal: Cell Date: 2011-09-02 Impact factor: 41.582

5. Inhibition of in vivo and in vitro transcription by monoclonal antibodies prepared against wheat germ RNA polymerase II that react with the heptapeptide repeat of eukaryotic RNA polymerase II.

Authors: N E Thompson; T H Steinberg; D B Aronson; R R Burgess
Journal: J Biol Chem Date: 1989-07-05 Impact factor: 5.157

Review 6. Transcription-coupled nucleotide excision repair in mammalian cells: molecular mechanisms and biological effects.

Authors: Maria Fousteri; Leon H F Mullenders
Journal: Cell Res Date: 2008-01 Impact factor: 25.617

7. Cell-type-specific consequences of nucleotide excision repair deficiencies: Embryonic stem cells versus fibroblasts.

Authors: Harm de Waard; Edwin Sonneveld; Jan de Wit; Rebecca Esveldt-van Lange; Jan H J Hoeijmakers; Harry Vrieling; Gijsbertus T J van der Horst
Journal: DNA Repair (Amst) Date: 2008-07-26

8. Phosphorylation-regulated binding of RNA polymerase II to fibrous polymers of low-complexity domains.

Authors: Ilmin Kwon; Masato Kato; Siheng Xiang; Leeju Wu; Pano Theodoropoulos; Hamid Mirzaei; Tina Han; Shanhai Xie; Jeffry L Corden; Steven L McKnight
Journal: Cell Date: 2013-11-21 Impact factor: 41.582

9. Galaxy: a comprehensive approach for supporting accessible, reproducible, and transparent computational research in the life sciences.

Authors: Jeremy Goecks; Anton Nekrutenko; James Taylor
Journal: Genome Biol Date: 2010-08-25 Impact factor: 13.583

10. The dyskerin ribonucleoprotein complex as an OCT4/SOX2 coactivator in embryonic stem cells.

Authors: Yick W Fong; Jaclyn J Ho; Carla Inouye; Robert Tjian
Journal: Elife Date: 2014-11-19 Impact factor: 8.140

23 in total

1. The dopamine receptor antagonist trifluoperazine prevents phenotype conversion and improves survival in mouse models of glioblastoma.

Authors: Kruttika Bhat; Mohammad Saki; Erina Vlashi; Fei Cheng; Sara Duhachek-Muggy; Claudia Alli; Garrett Yu; Paul Medina; Ling He; Robert Damoiseaux; Matteo Pellegrini; Nathan R Zemke; Phioanh Leia Nghiemphu; Timothy F Cloughesy; Linda M Liau; Harley I Kornblum; Frank Pajonk
Journal: Proc Natl Acad Sci U S A Date: 2020-05-01 Impact factor: 11.205

2. Nucleotide excision repair capacity increases during differentiation of human embryonic carcinoma cells into neurons and muscle cells.

Authors: Wentao Li; Wenjie Liu; Ayano Kakoki; Rujin Wang; Ogun Adebali; Yuchao Jiang; Aziz Sancar
Journal: J Biol Chem Date: 2019-02-26 Impact factor: 5.157

Functional and mechanistic studies of XPC DNA-repair complex as transcriptional coactivator in embryonic stem cells.

1. Centrin 2 stimulates nucleotide excision repair by interacting with xeroderma pigmentosum group C protein.

Review 2. The ubiquitin receptor Rad23: at the crossroads of nucleotide excision repair and proteasomal degradation.

3. A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity.

4. Control of embryonic stem cell lineage commitment by core promoter factor, TAF3.

5. Inhibition of in vivo and in vitro transcription by monoclonal antibodies prepared against wheat germ RNA polymerase II that react with the heptapeptide repeat of eukaryotic RNA polymerase II.

Review 6. Transcription-coupled nucleotide excision repair in mammalian cells: molecular mechanisms and biological effects.

7. Cell-type-specific consequences of nucleotide excision repair deficiencies: Embryonic stem cells versus fibroblasts.

8. Phosphorylation-regulated binding of RNA polymerase II to fibrous polymers of low-complexity domains.

9. Galaxy: a comprehensive approach for supporting accessible, reproducible, and transparent computational research in the life sciences.

10. The dyskerin ribonucleoprotein complex as an OCT4/SOX2 coactivator in embryonic stem cells.

1. The dopamine receptor antagonist trifluoperazine prevents phenotype conversion and improves survival in mouse models of glioblastoma.

2. Nucleotide excision repair capacity increases during differentiation of human embryonic carcinoma cells into neurons and muscle cells.

3. Architecture of the human XPC DNA repair and stem cell coactivator complex.

Review 4. XPC: Going where no DNA damage sensor has gone before.

5. Impact of DNA sequences on DNA 'opening' by the Rad4/XPC nucleotide excision repair complex.

6. OCT4A and the DNA damage response.

Review 7. Low complexity domains, condensates, and stem cell pluripotency.

Review 8. Global-genome Nucleotide Excision Repair Controlled by Ubiquitin/Sumo Modifiers.

9. Temporal activation of XRCC1-mediated DNA repair is essential for muscle differentiation.

Review 10. Xeroderma pigmentosum group C sensor: unprecedented recognition strategy and tight spatiotemporal regulation.