BACKGROUND: Cellular channels composed of connexin 43 are known to act as key players in the life cycle of the skin and consequently to underlie skin repair. OBJECTIVE: This study was specifically set up to investigate the suite of molecular mechanisms driven by connexin 43-based channels on wound healing. METHODS: To this end, a battery of parameters, including re-epithelialization, neovascularization, collagen deposition and extracellular matrix remodeling, was monitored over time during experimentally induced skin repair in heterozygous connexin 43 knockout mice. RESULTS: It was found that connexin 43 deficiency accelerates re-epithelialization and wound closure, increases proliferation and activation of dermal fibroblasts, and enhances the expression of extracellular matrix remodeling mediators. CONCLUSION: These data substantiate the notion that connexin 43 may represent an interesting therapeutic target in dermal wound healing.
BACKGROUND: Cellular channels composed of connexin 43 are known to act as key players in the life cycle of the skin and consequently to underlie skin repair. OBJECTIVE: This study was specifically set up to investigate the suite of molecular mechanisms driven by connexin 43-based channels on wound healing. METHODS: To this end, a battery of parameters, including re-epithelialization, neovascularization, collagen deposition and extracellular matrix remodeling, was monitored over time during experimentally induced skin repair in heterozygous connexin 43 knockout mice. RESULTS: It was found that connexin 43 deficiency accelerates re-epithelialization and wound closure, increases proliferation and activation of dermal fibroblasts, and enhances the expression of extracellular matrix remodeling mediators. CONCLUSION: These data substantiate the notion that connexin 43 may represent an interesting therapeutic target in dermal wound healing.
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