Literature DB >> 26211951

Connexin hemichannels influence genetically determined inflammatory and hyperproliferative skin diseases.

Noah A Levit1, Thomas W White2.   

Abstract

Connexin mutations underlie numerous human genetic diseases. Several connexin genes have been linked to skin diseases, and mechanistic studies have indicated that a gain of abnormal channel function may be responsible for pathology. The topical accessibility of the epidermal connexins, the existence of several mouse models of human skin disease, and the ongoing identification of pharmacological inhibitors targeting connexins provide an opportunity to test new therapeutic approaches.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Connexin; Gap junctions; Genetic disease; Inflammation; Inhibitor; KID syndrome; Skin

Mesh：

Substances：

Year:  2015        PMID： 26211951      PMCID： PMC4567508          DOI： 10.1016/j.phrs.2015.07.015

Source DB:  PubMed          Journal:  Pharmacol Res        ISSN： 1043-6618            Impact factor:   7.658


  149 in total

1.  Quinine blocks specific gap junction channel subtypes.

Authors:  M Srinivas; M G Hopperstad; D C Spray
Journal:  Proc Natl Acad Sci U S A       Date:  2001-09-04       Impact factor: 11.205

2.  Switch in gap junction protein expression is associated with selective changes in junctional permeability during keratinocyte differentiation.

Authors:  J L Brissette; N M Kumar; N B Gilula; J E Hall; G P Dotto
Journal:  Proc Natl Acad Sci U S A       Date:  1994-07-05       Impact factor: 11.205

3.  Connexin 26 (GJB2) mutations in two Swedish patients with atypical Vohwinkel (mutilating keratoderma plus deafness) and KID syndrome both extensively treated with acitretin.

Authors:  Marie-Louise Bondeson; Anna-Maja Nyström; Ulrika Gunnarsson; Anders Vahlquist
Journal:  Acta Derm Venereol       Date:  2006       Impact factor: 4.437

4.  Identification of aberrantly regulated genes in diseased skin using the cDNA differential display technique.

Authors:  M V Rivas; E D Jarvis; S Morisaki; H Carbonaro; A B Gottlieb; J G Krueger
Journal:  J Invest Dermatol       Date:  1997-02       Impact factor: 8.551

5.  Inhibition of CD44 gene expression in human skin models, using self-delivery short interfering RNA administered by dissolvable microneedle arrays.

Authors:  Maria Fernanda Lara; Emilio González-González; Tycho J Speaker; Robyn P Hickerson; Devin Leake; Leonard M Milstone; Christopher H Contag; Roger L Kaspar
Journal:  Hum Gene Ther       Date:  2012-06-05       Impact factor: 5.695

Review 6.  Treatment of keratitis-ichthyosis- deafness (KID) syndrome in children: a case report and review of the literature.

Authors:  Viraat Patel; Grace Sun; Meghan Dickman; Phuong Khuu; Joyce M C Teng
Journal:  Dermatol Ther       Date:  2014-12-29       Impact factor: 2.851

7.  Hereditary palmoplantar keratodermas.

Authors:  Markus Braun-Falco
Journal:  J Dtsch Dermatol Ges       Date:  2009-11       Impact factor: 5.584

8.  Visualization of plasmid delivery to keratinocytes in mouse and human epidermis.

Authors:  Emilio González-González; Yeu-Chun Kim; Tycho J Speaker; Robyn P Hickerson; Ryan Spitler; James C Birchall; Maria Fernanda Lara; Rong-Hua Hu; Yanhua Liang; Nancy Kirkiles-Smith; Mark R Prausnitz; Leonard M Milstone; Christopher H Contag; Roger L Kaspar
Journal:  Sci Rep       Date:  2011-11-15       Impact factor: 4.379

9.  GJB2 Gene Mutations in Syndromic Skin Diseases with Sensorineural Hearing Loss.

Authors:  Sandra Iossa; Elio Marciano; Annamaria Franzé
Journal:  Curr Genomics       Date:  2011-11       Impact factor: 2.236

10.  Hexagonal array of subunits in intercellular junctions of the mouse heart and liver.

Authors:  J P Revel; M J Karnovsky
Journal:  J Cell Biol       Date:  1967-06       Impact factor: 10.539
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  8 in total

Review 1.  Trends and challenges in phytotherapy and phytocosmetics for skin aging.

Authors:  Idris Adewale Ahmed; Maryam Abimbola Mikail; Nor Hisam Zamakshshari; Mohd Rais Mustafa; Najihah Mohd Hashim; Rozana Othman
Journal:  Saudi J Biol Sci       Date:  2022-06-23       Impact factor: 4.052

2.  Structural studies of N-terminal mutants of Connexin 26 and Connexin 32 using (1)H NMR spectroscopy.

Authors:  Yuksel Batir; Thaddeus A Bargiello; Terry L Dowd
Journal:  Arch Biochem Biophys       Date:  2016-07-01       Impact factor: 4.013

Review 3.  Connexins and their channels in inflammation.

Authors:  Joost Willebrords; Sara Crespo Yanguas; Michaël Maes; Elke Decrock; Nan Wang; Luc Leybaert; Brenda R Kwak; Colin R Green; Bruno Cogliati; Mathieu Vinken
Journal:  Crit Rev Biochem Mol Biol       Date:  2016-07-07       Impact factor: 8.250

Review 4.  The role of gap junctions in inflammatory and neoplastic disorders (Review).

Authors:  Pui Wong; Victoria Laxton; Saurabh Srivastava; Yin Wah Fiona Chan; Gary Tse
Journal:  Int J Mol Med       Date:  2017-01-17       Impact factor: 4.101

5.  Altered CO2 sensitivity of connexin26 mutant hemichannels in vitro.

Authors:  Elizabeth de Wolf; Joseph van de Wiel; Jonathan Cook; Nicholas Dale
Journal:  Physiol Rep       Date:  2016-11

Review 6.  Connexins and the Epithelial Tissue Barrier: A Focus on Connexin 26.

Authors:  Laura Garcia-Vega; Erin M O'Shaughnessy; Ahmad Albuloushi; Patricia E Martin
Journal:  Biology (Basel)       Date:  2021-01-14

7.  Connexin hemichannel inhibition ameliorates epidermal pathology in a mouse model of keratitis ichthyosis deafness syndrome.

Authors:  Caterina Sellitto; Leping Li; Thomas W White
Journal:  Sci Rep       Date:  2021-12-16       Impact factor: 4.379

8.  Specific functional pathologies of Cx43 mutations associated with oculodentodigital dysplasia.

Authors:  John J Kelly; Jessica L Esseltine; Qing Shao; Ethylin Wang Jabs; Jacinda Sampson; Mari Auranen; Donglin Bai; Dale W Laird
Journal:  Mol Biol Cell       Date:  2016-05-25       Impact factor: 4.138
  8 in total

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