Literature DB >> 25896640

ModelView for ModelDB: Online Presentation of Model Structure.

Robert A McDougal1, Thomas M Morse2, Michael L Hines2, Gordon M Shepherd2.   

Abstract

ModelDB ( modeldb.yale.edu ), a searchable repository of source code of more than 950 published computational neuroscience models, seeks to promote model reuse and reproducibility. Code sharing is a first step; however, model source code is often large and not easily understood. To aid users, we have developed ModelView, a web application for ModelDB that presents a graphical view of model structure augmented with contextual information for NEURON and NEURON-runnable (e.g. NeuroML, PyNN) models. Web presentation provides a rich, simulator-independent environment for interacting with graphs. The necessary data is generated by combining manual curation, text-mining the source code, querying ModelDB, and simulator introspection. Key features of the user interface along with the data analysis, storage, and visualization algorithms are explained. With this tool, researchers can examine and assess the structure of hundreds of models in ModelDB in a standardized presentation without installing any software, downloading the model, or reading model source code.

Entities:  

Keywords:  Code analysis; ModelDB; Repository; Visualization

Mesh:

Year:  2015        PMID: 25896640      PMCID: PMC4618280          DOI: 10.1007/s12021-015-9269-2

Source DB:  PubMed          Journal:  Neuroinformatics        ISSN: 1539-2791


  12 in total

1.  Role of an A-type K+ conductance in the back-propagation of action potentials in the dendrites of hippocampal pyramidal neurons.

Authors:  M Migliore; D A Hoffman; J C Magee; D Johnston
Journal:  J Comput Neurosci       Date:  1999 Jul-Aug       Impact factor: 1.621

Review 2.  NEURON: a tool for neuroscientists.

Authors:  M L Hines; N T Carnevale
Journal:  Neuroscientist       Date:  2001-04       Impact factor: 7.519

3.  ModelDB: making models publicly accessible to support computational neuroscience.

Authors:  Michele Migliore; Thomas M Morse; Andrew P Davison; Luis Marenco; Gordon M Shepherd; Michael L Hines
Journal:  Neuroinformatics       Date:  2003

Review 4.  Model structure analysis in NEURON : toward interoperability among neural simulators.

Authors:  Michael L Hines; Tom M Morse; N T Carnevale
Journal:  Methods Mol Biol       Date:  2007

5.  NeuroML: a language for describing data driven models of neurons and networks with a high degree of biological detail.

Authors:  Padraig Gleeson; Sharon Crook; Robert C Cannon; Michael L Hines; Guy O Billings; Matteo Farinella; Thomas M Morse; Andrew P Davison; Subhasis Ray; Upinder S Bhalla; Simon R Barnes; Yoana D Dimitrova; R Angus Silver
Journal:  PLoS Comput Biol       Date:  2010-06-17       Impact factor: 4.475

6.  Abnormal Excitability of Oblique Dendrites Implicated in Early Alzheimer's: A Computational Study.

Authors:  Thomas M Morse; Nicholas T Carnevale; Pradeep G Mutalik; Michele Migliore; Gordon M Shepherd
Journal:  Front Neural Circuits       Date:  2010-05-31       Impact factor: 3.492

7.  Rapid desynchronization of an electrically coupled interneuron network with sparse excitatory synaptic input.

Authors:  Koen Vervaeke; Andrea Lorincz; Padraig Gleeson; Matteo Farinella; Zoltan Nusser; R Angus Silver
Journal:  Neuron       Date:  2010-08-12       Impact factor: 17.173

8.  PyNN: A Common Interface for Neuronal Network Simulators.

Authors:  Andrew P Davison; Daniel Brüderle; Jochen Eppler; Jens Kremkow; Eilif Muller; Dejan Pecevski; Laurent Perrinet; Pierre Yger
Journal:  Front Neuroinform       Date:  2009-01-27       Impact factor: 4.081

9.  BioModels Database: a free, centralized database of curated, published, quantitative kinetic models of biochemical and cellular systems.

Authors:  Nicolas Le Novère; Benjamin Bornstein; Alexander Broicher; Mélanie Courtot; Marco Donizelli; Harish Dharuri; Lu Li; Herbert Sauro; Maria Schilstra; Bruce Shapiro; Jacky L Snoep; Michael Hucka
Journal:  Nucleic Acids Res       Date:  2006-01-01       Impact factor: 16.971

10.  neuroConstruct: a tool for modeling networks of neurons in 3D space.

Authors:  Padraig Gleeson; Volker Steuber; R Angus Silver
Journal:  Neuron       Date:  2007-04-19       Impact factor: 17.173

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  10 in total

Review 1.  Is realistic neuronal modeling realistic?

Authors:  Mara Almog; Alon Korngreen
Journal:  J Neurophysiol       Date:  2016-08-17       Impact factor: 2.714

2.  Data Management in Computational Systems Biology: Exploring Standards, Tools, Databases, and Packaging Best Practices.

Authors:  Natalie J Stanford; Martin Scharm; Paul D Dobson; Martin Golebiewski; Michael Hucka; Varun B Kothamachu; David Nickerson; Stuart Owen; Jürgen Pahle; Ulrike Wittig; Dagmar Waltemath; Carole Goble; Pedro Mendes; Jacky Snoep
Journal:  Methods Mol Biol       Date:  2019

Review 3.  Twenty years of ModelDB and beyond: building essential modeling tools for the future of neuroscience.

Authors:  Robert A McDougal; Thomas M Morse; Ted Carnevale; Luis Marenco; Rixin Wang; Michele Migliore; Perry L Miller; Gordon M Shepherd; Michael L Hines
Journal:  J Comput Neurosci       Date:  2016-09-15       Impact factor: 1.621

4.  Reproducibility in Computational Neuroscience Models and Simulations.

Authors:  Robert A McDougal; Anna S Bulanova; William W Lytton
Journal:  IEEE Trans Biomed Eng       Date:  2016-03-08       Impact factor: 4.538

5.  Computational model of a positive BDNF feedback loop in hippocampal neurons following inhibitory avoidance training.

Authors:  Yili Zhang; Paul Smolen; Cristina M Alberini; Douglas A Baxter; John H Byrne
Journal:  Learn Mem       Date:  2016-11-15       Impact factor: 2.460

6.  Biphasic Regulation of p38 MAPK by Serotonin Contributes to the Efficacy of Stimulus Protocols That Induce Long-Term Synaptic Facilitation.

Authors:  Yili Zhang; Paul Smolen; Douglas A Baxter; John H Byrne
Journal:  eNeuro       Date:  2017-02-14

7.  NetPyNE, a tool for data-driven multiscale modeling of brain circuits.

Authors:  Salvador Dura-Bernal; Benjamin A Suter; Padraig Gleeson; Matteo Cantarelli; Adrian Quintana; Facundo Rodriguez; David J Kedziora; George L Chadderdon; Cliff C Kerr; Samuel A Neymotin; Robert A McDougal; Michael Hines; Gordon Mg Shepherd; William W Lytton
Journal:  Elife       Date:  2019-04-26       Impact factor: 8.140

8.  Computational analysis of memory consolidation following inhibitory avoidance (IA) training in adult and infant rats: Critical roles of CaMKIIα and MeCP2.

Authors:  Yili Zhang; Paul Smolen; Cristina M Alberini; Douglas A Baxter; John H Byrne
Journal:  PLoS Comput Biol       Date:  2022-06-27       Impact factor: 4.779

9.  The EBRAINS Hodgkin-Huxley Neuron Builder: An online resource for building data-driven neuron models.

Authors:  Luca Leonardo Bologna; Roberto Smiriglia; Carmen Alina Lupascu; Shailesh Appukuttan; Andrew P Davison; Genrich Ivaska; Jean-Denis Courcol; Michele Migliore
Journal:  Front Neuroinform       Date:  2022-09-26       Impact factor: 3.739

10.  Quantitative description of the interactions among kinase cascades underlying long-term plasticity of Aplysia sensory neurons.

Authors:  Yili Zhang; Paul D Smolen; Leonard J Cleary; John H Byrne
Journal:  Sci Rep       Date:  2021-07-22       Impact factor: 4.379

  10 in total

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