OBJECTIVE: Prior investigations demonstrated that autoantibodies recognizing cytosolic 5'-nucleotidase 1A (NT5C1A) are found in 33-76% of patients with inclusion body myositis (IBM) but are observed only rarely in patients with polymyositis (PM). Thus, anti-NT5C1A may help distinguish IBM from PM. Although 4-21% of patients with dermatomyositis (DM) were shown to be anti-NT5C1A antibody positive, the clinical features of anti-NT5C1A-positive patients with DM have not been described. Furthermore, the prevalence of anti-NT5C1A antibodies in other rheumatic conditions has not been reported. This study was undertaken to define the prevalence and clinical features of anti-NT5C1A-positive patients with DM, PM, IBM, or other systemic autoimmune diseases. METHODS: We screened for anti-NT5C1A autoantibodies in patients with IBM, DM, PM, Sjögren's syndrome (SS), or systemic lupus erythematosus (SLE) and in healthy volunteers. Clinical characteristics were compared between patients who were anti-NT5C1A positive and those who were anti-NT5C1A negative. RESULTS: Anti-NT5C1A autoantibodies were detected in 71 (61%) of 117 patients with IBM, 2 (5%) of 42 patients with PM, 2 (5%) of 42 healthy volunteers, 24 (15%) of 159 patients with DM, 10 (23%) of 44 patients with SS, and 13 (14%) of 96 patients with SLE. No anti-NT5C1A antibody-positive patients with SS or SLE had muscle involvement. Anti-NT5C1A-positive patients with IBM had a lower prevalence of rimmed vacuoles (62% versus 83% of antibody-negative patients; P = 0.02). No differences in the clinical characteristics of antibody-positive and antibody-negative patients with DM, SS, or SLE were observed. CONCLUSION: Anti-NT5C1A is a common target of circulating autoantibodies, especially in IBM but also in several different autoimmune diseases. In SLE and SS, anti-NT5C1A autoreactivity is not associated with muscle disease.
OBJECTIVE: Prior investigations demonstrated that autoantibodies recognizing cytosolic 5'-nucleotidase 1A (NT5C1A) are found in 33-76% of patients with inclusion body myositis (IBM) but are observed only rarely in patients with polymyositis (PM). Thus, anti-NT5C1A may help distinguish IBM from PM. Although 4-21% of patients with dermatomyositis (DM) were shown to be anti-NT5C1A antibody positive, the clinical features of anti-NT5C1A-positive patients with DM have not been described. Furthermore, the prevalence of anti-NT5C1A antibodies in other rheumatic conditions has not been reported. This study was undertaken to define the prevalence and clinical features of anti-NT5C1A-positive patients with DM, PM, IBM, or other systemic autoimmune diseases. METHODS: We screened for anti-NT5C1A autoantibodies in patients with IBM, DM, PM, Sjögren's syndrome (SS), or systemic lupus erythematosus (SLE) and in healthy volunteers. Clinical characteristics were compared between patients who were anti-NT5C1A positive and those who were anti-NT5C1A negative. RESULTS: Anti-NT5C1A autoantibodies were detected in 71 (61%) of 117 patients with IBM, 2 (5%) of 42 patients with PM, 2 (5%) of 42 healthy volunteers, 24 (15%) of 159 patients with DM, 10 (23%) of 44 patients with SS, and 13 (14%) of 96 patients with SLE. No anti-NT5C1A antibody-positive patients with SS or SLE had muscle involvement. Anti-NT5C1A-positive patients with IBM had a lower prevalence of rimmed vacuoles (62% versus 83% of antibody-negative patients; P = 0.02). No differences in the clinical characteristics of antibody-positive and antibody-negative patients with DM, SS, or SLE were observed. CONCLUSION: Anti-NT5C1A is a common target of circulating autoantibodies, especially in IBM but also in several different autoimmune diseases. In SLE and SS, anti-NT5C1A autoreactivity is not associated with muscle disease.
Authors: H Benjamin Larman; Mohammad Salajegheh; Remedios Nazareno; Theresa Lam; John Sauld; Hanno Steen; Sek Won Kong; Jack L Pinkus; Anthony A Amato; Stephen J Elledge; Steven A Greenberg Journal: Ann Neurol Date: 2013-03 Impact factor: 10.422
Authors: Helma Pluk; Bas J A van Hoeve; Sander H J van Dooren; Judith Stammen-Vogelzangs; Annemarie van der Heijden; Helenius J Schelhaas; Marcel M Verbeek; Umesh A Badrising; Snjolaug Arnardottir; Karina Gheorghe; Ingrid E Lundberg; Wilbert C Boelens; Baziel G van Engelen; Ger J M Pruijn Journal: Ann Neurol Date: 2013-03-04 Impact factor: 10.422
Authors: Thomas E Lloyd; Andrew L Mammen; Anthony A Amato; Michael D Weiss; Merrilee Needham; Steven A Greenberg Journal: Neurology Date: 2014-06-27 Impact factor: 9.910
Authors: Richard M Yeker; Iago Pinal-Fernandez; Lisa G Rider; Andrew L Mammen; Takayuki Kishi; Katherine Pak; Ira N Targoff; Frederick W Miller Journal: Ann Rheum Dis Date: 2018-01-23 Impact factor: 19.103
Authors: Thomas E Lloyd; Iago Pinal-Fernandez; E Harlan Michelle; Lisa Christopher-Stine; Katherine Pak; Ned Sacktor; Andrew L Mammen Journal: Neurology Date: 2017-03-10 Impact factor: 9.910
Authors: Jose C Milisenda; Iago Pinal-Fernandez; Thomas E Lloyd; Josep María Grau; Frederick W Miller; Albert Selva-O'Callaghan; Lisa Christopher-Stine; Werner Stenzel; Andrew L Mammen; Andrea M Corse Journal: Clin Exp Rheumatol Date: 2020-09-01 Impact factor: 4.862