Albert Selva-O'Callaghan1, Albert Gil-Vila2, Marc Simó-Perdigó3, Ernesto Trallero-Araguás4, Marcelo Alvarado-Cárdenas2, Iago Pinal-Fernandez5,6. 1. Internal Medicine Department, Vall d'Hebron General Hospital, Universitat Autónoma de Barcelona, Barcelona, Spain. aselva@vhebron.net. 2. Internal Medicine Department, Vall d'Hebron General Hospital, Universitat Autónoma de Barcelona, Barcelona, Spain. 3. Nuclear Medicine Department, Vall d'Hebron General Hospital, Barcelona, Spain. 4. Rheumatology Unit, Vall D'Hebron General Hospital, , Barcelona, Spain. 5. National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Johns Hopkins University School of Medicine, Baltimore, USA. 6. Faculty of Health Sciences, Universitat Oberta de Catalunya, Barcelona, Spain.
Abstract
PURPOSE OF REVIEW: Positron emission tomography (PET) combined with computed tomography (CT) has proven useful as a cancer screening technique in patients with inflammatory myopathy, mainly dermatomyositis. In this review, we focus on advances in this direction and other potential applications of PET/CT in patients with inflammatory myopathy. RECENT FINDINGS: Cancer screening by PET/CT seems suitable and cost-effective in patients with myositis. It has also shown value as a hybrid technique for diagnosing myositis versus controls and could be of interest for differentiating between polymyositis and sporadic inclusion body myositis. Quantification of muscle activity by PET/CT seems reliable. Preliminary data suggest that it could also be used to diagnose and measure the activity of the disease in the lung. PET/CT should be in the toolbox of physicians managing patients with myositis. The multiple applications of PET/CT include its value for cancer screening, measuring the activity of the disease in muscle, and helping to differentiate between myositis phenotypes. The possibility to diagnose and monitor inflammatory lung activity remains to be demonstrated in well-designed studies.
PURPOSE OF REVIEW: Positron emission tomography (PET) combined with computed tomography (CT) has proven useful as a cancer screening technique in patients with inflammatory myopathy, mainly dermatomyositis. In this review, we focus on advances in this direction and other potential applications of PET/CT in patients with inflammatory myopathy. RECENT FINDINGS:Cancer screening by PET/CT seems suitable and cost-effective in patients with myositis. It has also shown value as a hybrid technique for diagnosing myositis versus controls and could be of interest for differentiating between polymyositis and sporadic inclusion body myositis. Quantification of muscle activity by PET/CT seems reliable. Preliminary data suggest that it could also be used to diagnose and measure the activity of the disease in the lung. PET/CT should be in the toolbox of physicians managing patients with myositis. The multiple applications of PET/CT include its value for cancer screening, measuring the activity of the disease in muscle, and helping to differentiate between myositis phenotypes. The possibility to diagnose and monitor inflammatory lung activity remains to be demonstrated in well-designed studies.
Entities:
Keywords:
Activity; Dermatomyositis; Malignancy; Myositis; PET/CT; Sporadic inclusion body myositis
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