G Y Liu1, T O Utset2, J T Bernard3. 1. University of Chicago, Chicago, USA gyliu@uchicago.edu. 2. Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, USA. 3. Department of Neurology, University of Chicago, Chicago, USA.
Abstract
OBJECTIVE: Due to the lack of reliable biomarkers in diagnosing and monitoring neuropsychiatric systemic lupus erythematosus (NPSLE), the aim of this study was to examine the utility of measurements obtained through spectral domain optical coherence tomography (SD-OCT) as a biomarker for NP involvement in SLE. METHODS: Retinal nerve fiber layer (RNFL) and macula scans were performed using SD-OCT on 15 NPSLE patients, 16 SLE patients without NP symptoms (non-NP SLE), and 16 healthy controls. Macular volume and thickness of the central macula and peripapillary RNFL were compared between the groups and to scores on two validated cognitive tests. RESULTS: NPSLE patients did not differ significantly from non-NP SLE patients in retinal thickness or macular volume. However, SLE patients as a whole showed significant RNFL and macular thinning compared to controls. Scores on the Trail Making Test B, a test of complex attention, showed significant correlation to temporal superior and temporal inferior RNFL thickness. CONCLUSION: Our results demonstrate RNFL thinning in SLE, and confirm the previous finding of high incidence of abnormal brain scans in SLE. These findings suggest that OCT measurements may be indicative of neurodegeneration in SLE and may be a useful biomarker for early cognitive impairment in SLE.
OBJECTIVE: Due to the lack of reliable biomarkers in diagnosing and monitoring neuropsychiatric systemic lupus erythematosus (NPSLE), the aim of this study was to examine the utility of measurements obtained through spectral domain optical coherence tomography (SD-OCT) as a biomarker for NP involvement in SLE. METHODS: Retinal nerve fiber layer (RNFL) and macula scans were performed using SD-OCT on 15 NPSLE patients, 16 SLEpatients without NP symptoms (non-NP SLE), and 16 healthy controls. Macular volume and thickness of the central macula and peripapillary RNFL were compared between the groups and to scores on two validated cognitive tests. RESULTS: NPSLE patients did not differ significantly from non-NP SLEpatients in retinal thickness or macular volume. However, SLEpatients as a whole showed significant RNFL and macular thinning compared to controls. Scores on the Trail Making Test B, a test of complex attention, showed significant correlation to temporal superior and temporal inferior RNFL thickness. CONCLUSION: Our results demonstrate RNFL thinning in SLE, and confirm the previous finding of high incidence of abnormal brain scans in SLE. These findings suggest that OCT measurements may be indicative of neurodegeneration in SLE and may be a useful biomarker for early cognitive impairment in SLE.
Authors: Leonieke M E van Koolwijk; Dominiek D G Despriet; Cornelia M Van Duijn; Ben A Oostra; John C van Swieten; Inge de Koning; Caroline C W Klaver; Hans G Lemij Journal: Invest Ophthalmol Vis Sci Date: 2009-05-06 Impact factor: 4.799
Authors: Sarah Stricker; Timm Oberwahrenbrock; Hanna Zimmermann; Jan Schroeter; Matthias Endres; Alexander U Brandt; Friedemann Paul Journal: PLoS One Date: 2011-07-29 Impact factor: 3.240
Authors: Samantha Sze-Yee Lee; Gareth Lingham; David Alonso-Caneiro; Jason Charng; Fred Kuanfu Chen; Seyhan Yazar; David Anthony Mackey Journal: Transl Vis Sci Technol Date: 2021-03-01 Impact factor: 3.283
Authors: Samantha Sze-Yee Lee; Darren John Beales; Fred K Chen; Seyhan Yazar; David Alonso-Caneiro; David A Mackey Journal: Sci Rep Date: 2021-03-17 Impact factor: 4.379
Authors: Arnaldo Dias-Santos; Joana Tavares Ferreira; Sofia Pinheiro; João Paulo Cunha; Marta Alves; Ana L Papoila; Maria Francisca Moraes-Fontes; Rui Proença Journal: Int J Retina Vitreous Date: 2020-04-21