Mehmed Uğur Işık1, Berkay Akmaz2, Fahrettin Akay2, Yusuf Ziya Güven2, Dilek Solmaz3, Önay Gercik3, Gökhan Kabadayı3, İdil Kurut3, Servet Akar3. 1. Department of Ophthalmology, Kastamonu University Faculty of Medicine, Kastamonu, Turkey. mehmedugur@windowslive.com. 2. Department of Ophthalmology, İzmir Katip Çelebi University Atatürk Educating and Research Hospital, İzmir, Turkey. 3. Department of Internal Medicine and Division of Rheumatology, İzmir Katip Çelebi University Atatürk Educating and Research Hospital, İzmir, Turkey.
Abstract
PURPOSE: To evaluate the choroidal and retinal layers with optical coherence tomography (OCT) and retinal microvascular structures with optical coherence tomography angiography (OCTA) in systemic lupus erythematosus (SLE) patients. METHOD: In this prospective, cross-sectional and comparative study, a total of 35 SLE patients and 35 healthy control participants were included. SLE patients who were using hydroxychloroquine (HCQ) and/or immunosuppressive agents are evaluated with OCT and OCTA. SLE patients who have no HCQ maculopathy observed in OCT were included in the patient group. RESULTS: Mean macular thickness and ganglion cell inner plexiform layer (GC-IPL) thicknesses were thinner in the patient group. When the parameters obtained with OCTA were evaluated, vessel (VD) and perfusion density (PD) were significantly lower in the patient group. Central foveal thickness and foveal avascular zone parameters were negatively correlated. In addition, VD and PD, and GC-IPL thicknesses were positively correlated. CONCLUSION: Application of OCTA for the evaluation of microvasculature in SLE patients may be useful in subclinical changes.
PURPOSE: To evaluate the choroidal and retinal layers with optical coherence tomography (OCT) and retinal microvascular structures with optical coherence tomography angiography (OCTA) in systemic lupus erythematosus (SLE) patients. METHOD: In this prospective, cross-sectional and comparative study, a total of 35 SLEpatients and 35 healthy control participants were included. SLEpatients who were using hydroxychloroquine (HCQ) and/or immunosuppressive agents are evaluated with OCT and OCTA. SLEpatients who have no HCQmaculopathy observed in OCT were included in the patient group. RESULTS: Mean macular thickness and ganglion cell inner plexiform layer (GC-IPL) thicknesses were thinner in the patient group. When the parameters obtained with OCTA were evaluated, vessel (VD) and perfusion density (PD) were significantly lower in the patient group. Central foveal thickness and foveal avascular zone parameters were negatively correlated. In addition, VD and PD, and GC-IPL thicknesses were positively correlated. CONCLUSION: Application of OCTA for the evaluation of microvasculature in SLEpatients may be useful in subclinical changes.
Authors: Michael F Marmor; Ulrich Kellner; Timothy Y Y Lai; Ronald B Melles; William F Mieler Journal: Ophthalmology Date: 2016-03-16 Impact factor: 12.079