Samantha Sze-Yee Lee1, Gareth Lingham1, David Alonso-Caneiro2, Jason Charng1, Fred Kuanfu Chen1,3, Seyhan Yazar1,4, David Anthony Mackey1,5,6. 1. Centre for Ophthalmology and Visual Science (incorporating the Lions Eye Institute), University of Western Australia, Western Australia, Australia. 2. Queensland University of Technology, Contact Lens and Visual Optics Laboratory, Centre for Vision and Eye Research, School of Optometry and Vision Science, Queensland, Australia. 3. Royal Perth Hospital, Western Australia, Australia. 4. Single Cell and Computational Genomics Lab, Garvan Institute of Medical Research, New South Wales, Australia. 5. Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Victoria, Australia. 6. School of Medicine, Menzies Research Institute Tasmania, University of Tasmania, Tasmania, Australia.
Abstract
Purpose: To describe the thickness profiles of the full retinal and outer retinal layers (ORL) at the macula in healthy young adults, and associations with best-corrected visual acuity (BCVA). Methods: In total, 1604 participants (19-30 years) underwent an eye examination that included measurements of their BCVA, axial length, and autorefraction. The retinal thickness at the foveal pit and at the nine Early Treatment of Diabetic Retinopathy Study macular regions (0.5-mm radius around the fovea, and superior, inferior, temporal, and nasal quadrants of the inner and outer rings of the macula) were obtained using spectral-domain optical coherence tomography imaging. A custom program was used to correct for transverse magnification effects because of different axial lengths. Results: The median full retinal and ORL thicknesses at the central macula were 285 µm and 92 µm. The full retina was thinnest centrally and thickest at the inner macula ring, whereas the ORL was thickest centrally and gradually decreased in thickness with increasing eccentricity. There was no association between axial length and the full retinal or ORL thickness. Increased thicknesses of the full retina at the central macula was associated with better BCVA; however, the effect size was small and not clinically significant. Conclusions: This article mapped the full retinal and ORL thickness profile in a population-based sample of young healthy adults. Translational Relevance: Thickness values presented in this article could be used as a normative reference for future studies on young adults and in clinical practice.
Purpose: To describe the thickness profiles of the full retinal and outer retinal layers (ORL) at the macula in healthy young adults, and associations with best-corrected visual acuity (BCVA). Methods: In total, 1604 participants (19-30 years) underwent an eye examination that included measurements of their BCVA, axial length, and autorefraction. The retinal thickness at the foveal pit and at the nine Early Treatment of Diabetic Retinopathy Study macular regions (0.5-mm radius around the fovea, and superior, inferior, temporal, and nasal quadrants of the inner and outer rings of the macula) were obtained using spectral-domain optical coherence tomography imaging. A custom program was used to correct for transverse magnification effects because of different axial lengths. Results: The median full retinal and ORL thicknesses at the central macula were 285 µm and 92 µm. The full retina was thinnest centrally and thickest at the inner macula ring, whereas the ORL was thickest centrally and gradually decreased in thickness with increasing eccentricity. There was no association between axial length and the full retinal or ORL thickness. Increased thicknesses of the full retina at the central macula was associated with better BCVA; however, the effect size was small and not clinically significant. Conclusions: This article mapped the full retinal and ORL thickness profile in a population-based sample of young healthy adults. Translational Relevance: Thickness values presented in this article could be used as a normative reference for future studies on young adults and in clinical practice.
Authors: Christiane E Al-Haddad; Georges M E L Mollayess; Carol G Cherfan; Dalida F Jaafar; Ziad F Bashshur Journal: Br J Ophthalmol Date: 2011-03-11 Impact factor: 4.638
Authors: Gareth Lingham; Elizabeth Milne; Donna Cross; Dallas R English; Robyn S Johnston; Robyn M Lucas; Seyhan Yazar; David A Mackey Journal: BMJ Open Date: 2018-01-31 Impact factor: 2.692
Authors: Hamed Niyazmand; Gareth Lingham; Paul G Sanfilippo; Magdalena Blaszkowska; Maria Franchina; Seyhan Yazar; David Alonso-Caneiro; David A Mackey; Samantha Sze-Yee Lee Journal: PLoS One Date: 2022-04-13 Impact factor: 3.240
Authors: Martin A Mainster; Thomas Desmettre; Giuseppe Querques; Patricia L Turner; Gerardo Ledesma-Gil Journal: Int J Retina Vitreous Date: 2022-09-30