Literature DB >> 25882792

Amphipathic DNA origami nanoparticles to scaffold and deform lipid membrane vesicles.

Aleksander Czogalla1,2, Dominik J Kauert3, Henri G Franquelim4, Veselina Uzunova5, Yixin Zhang5, Ralf Seidel3, Petra Schwille6.   

Abstract

We report a synthetic biology-inspired approach for the engineering of amphipathic DNA origami structures as membrane-scaffolding tools. The structures have a flat membrane-binding interface decorated with cholesterol-derived anchors. Sticky oligonucleotide overhangs on their side facets enable lateral interactions leading to the formation of ordered arrays on the membrane. Such a tight and regular arrangement makes our DNA origami capable of deforming free-standing lipid membranes, mimicking the biological activity of coat-forming proteins, for example, from the I-/F-BAR family.
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  diffusion; lipid membranes; membrane deformation; oligomerization; origami DNA structures

Mesh：

Substances：

Year:  2015        PMID： 25882792     DOI： 10.1002/anie.201501173

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  24 in total

Review 1.  Building membrane nanopores.

Authors:  Stefan Howorka
Journal:  Nat Nanotechnol       Date:  2017-07-06       Impact factor: 39.213

2.  DNA nanotechnology: Bringing lipid bilayers into shape.

Authors:  Stefan Howorka
Journal:  Nat Chem       Date:  2017-06-23       Impact factor: 24.427

3.  Facile Assembly/Disassembly of DNA Nanostructures Anchored on Cell-Mimicking Giant Vesicles.

Authors:  Ruizi Peng; Huijing Wang; Yifan Lyu; Liujun Xu; Hui Liu; Hailan Kuai; Qiaoling Liu; Weihong Tan
Journal:  J Am Chem Soc       Date:  2017-08-30       Impact factor: 15.419

Review 4.  Multiscale simulations of protein-facilitated membrane remodeling.

Authors:  Aram Davtyan; Mijo Simunovic; Gregory A Voth
Journal:  J Struct Biol       Date:  2016-06-17       Impact factor: 2.867

5.  Vesicle Tubulation with Self-Assembling DNA Nanosprings.

Authors:  Michael W Grome; Zhao Zhang; Frédéric Pincet; Chenxiang Lin
Journal:  Angew Chem Int Ed Engl       Date:  2018-04-14       Impact factor: 15.336

Review 6.  Engineering Lipid Membranes with Programmable DNA Nanostructures.

Authors:  Qi Shen; Michael W Grome; Yang Yang; Chenxiang Lin
Journal:  Adv Biosyst       Date:  2019-12-09

7.  Membrane sculpting by curved DNA origami scaffolds.

Authors:  Henri G Franquelim; Alena Khmelinskaia; Jean-Philippe Sobczak; Hendrik Dietz; Petra Schwille
Journal:  Nat Commun       Date:  2018-02-23       Impact factor: 14.919

Review 8.  DNA origami applications in cancer therapy.

Authors:  Anuttara Udomprasert; Thaned Kangsamaksin
Journal:  Cancer Sci       Date:  2017-07-03       Impact factor: 6.716

9.  Proton gradients from light-harvesting E. coli control DNA assemblies for synthetic cells.

Authors:  Kevin Jahnke; Noah Ritzmann; Julius Fichtler; Anna Nitschke; Yannik Dreher; Tobias Abele; Götz Hofhaus; Ilia Platzman; Rasmus R Schröder; Daniel J Müller; Joachim P Spatz; Kerstin Göpfrich
Journal:  Nat Commun       Date:  2021-06-25       Impact factor: 14.919

Review 10.  DNA Nanostructures on Membranes as Tools for Synthetic Biology.

Authors:  Aleksander Czogalla; Henri G Franquelim; Petra Schwille
Journal:  Biophys J       Date:  2016-04-26       Impact factor: 4.033
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