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Literature DB >> 25877199

Organic chemistry: Streamlining drug synthesis.

Joel M Hawkins¹.

Abstract

Mesh：

Substances：
Rolipram

Year: 2015 PMID： 25877199 DOI： 10.1038/520302a

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

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8 in total

1. Multistep continuous-flow synthesis of (R)- and (S)-rolipram using heterogeneous catalysts.

Authors: Tetsu Tsubogo; Hidekazu Oyamada; Shū Kobayashi
Journal: Nature Date: 2015-04-16 Impact factor: 49.962

Review 2. Flow chemistry syntheses of natural products.

Authors: Julio C Pastre; Duncan L Browne; Steven V Ley
Journal: Chem Soc Rev Date: 2013-09-02 Impact factor: 54.564

3. A three-minute synthesis and purification of ibuprofen: pushing the limits of continuous-flow processing.

Authors: David R Snead; Timothy F Jamison
Journal: Angew Chem Int Ed Engl Date: 2014-12-02 Impact factor: 15.336

Review 4. Achieving continuous manufacturing: technologies and approaches for synthesis, workup, and isolation of drug substance. May 20-21, 2014 Continuous Manufacturing Symposium.

Authors: Ian R Baxendale; Richard D Braatz; Benjamin K Hodnett; Klavs F Jensen; Martin D Johnson; Paul Sharratt; Jon-Paul Sherlock; Alastair J Florence
Journal: J Pharm Sci Date: 2014-12-02 Impact factor: 3.534

1 in total

Review 1. Enabling Technologies for the Future of Chemical Synthesis.

Authors: Daniel E Fitzpatrick; Claudio Battilocchio; Steven V Ley
Journal: ACS Cent Sci Date: 2016-02-24 Impact factor: 14.553

1 in total

Organic chemistry: Streamlining drug synthesis.

1. Multistep continuous-flow synthesis of (R)- and (S)-rolipram using heterogeneous catalysts.

Review 2. Flow chemistry syntheses of natural products.

3. A three-minute synthesis and purification of ibuprofen: pushing the limits of continuous-flow processing.

Review 4. Achieving continuous manufacturing: technologies and approaches for synthesis, workup, and isolation of drug substance. May 20-21, 2014 Continuous Manufacturing Symposium.

5. A mild and efficient flow procedure for the transfer hydrogenation of ketones and aldehydes using hydrous zirconia.

6. A flow-based synthesis of imatinib: the API of Gleevec.

7. Mild and selective heterogeneous catalytic hydration of nitriles to amides by flowing through manganese dioxide.

8. Sustainable flow Oppenauer oxidation of secondary benzylic alcohols with a heterogeneous zirconia catalyst.

Review 1. Enabling Technologies for the Future of Chemical Synthesis.