Literature DB >> 20309467

A flow-based synthesis of imatinib: the API of Gleevec.

Mark D Hopkin1, Ian R Baxendale, Steven V Ley.   

Abstract

A concise, flow-based synthesis of Imatinib, a compound used for the treatment of chronic myeloid leukaemia, is described whereby all steps are conducted in tubular flow coils or cartridges packed with reagents or scavengers to effect clean product formation. An in-line solvent switching procedure was developed enabling the procedure to be performed with limited manual handling of intermediates.

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Year:  2010        PMID： 20309467     DOI： 10.1039/c001550d

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  17 in total

1.  The flow synthesis of heterocycles for natural product and medicinal chemistry applications.

Authors:  Marcus Baumann; Ian R Baxendale; Steven V Ley
Journal:  Mol Divers       Date:  2010-10-20       Impact factor: 2.943

Review 2.  Drug repurposing for the treatment of COVID-19: Pharmacological aspects and synthetic approaches.

Authors:  Pedro N Batalha; Luana S M Forezi; Carolina G S Lima; Fernanda P Pauli; Fernanda C S Boechat; Maria Cecília B V de Souza; Anna C Cunha; Vitor F Ferreira; Fernando de C da Silva
Journal:  Bioorg Chem       Date:  2020-11-19       Impact factor: 5.275

3.  Organic chemistry: Streamlining drug synthesis.

Authors:  Joel M Hawkins
Journal:  Nature       Date:  2015-04-16       Impact factor: 49.962

4.  Facile (triazolyl)methylation of MACOS-derived benzofused sultams utilizing ROMP-derived OTP reagents.

Authors:  Saqib Faisal; Farman Ullah; Pradip K Maity; Alan Rolfe; Thiwanka B Samarakoon; Patrick Porubsky; Benjamin Neuenswander; Gerald H Lushington; Fatima Z Basha; Michael G Organ; Paul R Hanson
Journal:  ACS Comb Sci       Date:  2012-03-05       Impact factor: 3.784

5.  Palladium-Catalyzed Coupling of Functionalized Primary and Secondary Amines with Aryl and Heteroaryl Halides: Two Ligands Suffice in Most Cases.

Authors:  Debabrata Maiti; Brett P Fors; Jaclyn L Henderson; Yoshinori Nakamura; Stephen L Buchwald
Journal:  Chem Sci       Date:  2011-01-01       Impact factor: 9.825

Review 6.  Automating drug discovery.

Authors:  Gisbert Schneider
Journal:  Nat Rev Drug Discov       Date:  2017-12-15       Impact factor: 84.694

7.  The development of a general strategy for the synthesis of tyramine-based natural products by using continuous flow techniques.

Authors:  Srinivas Achanta; Virginie Liautard; Robert Paugh; Michael G Organ
Journal:  Chemistry       Date:  2010-11-15       Impact factor: 5.236

Review 8.  Applications of Palladium-Catalyzed C-N Cross-Coupling Reactions.

Authors:  Paula Ruiz-Castillo; Stephen L Buchwald
Journal:  Chem Rev       Date:  2016-09-30       Impact factor: 60.622

Review 9.  The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry.

Authors:  Marcus Baumann; Ian R Baxendale
Journal:  Beilstein J Org Chem       Date:  2015-07-17       Impact factor: 2.883

10.  Camera-enabled techniques for organic synthesis.

Authors:  Steven V Ley; Richard J Ingham; Matthew O'Brien; Duncan L Browne
Journal:  Beilstein J Org Chem       Date:  2013-05-31       Impact factor: 2.883
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