Literature DB >> 25873209

Acylsulfonamide-Functionalized Zwitterionic Gold Nanoparticles for Enhanced Cellular Uptake at Tumor pH.

Tsukasa Mizuhara1,2, Krishnendu Saha1, Daniel F Moyano1, Chang Soo Kim1, Bo Yan1, Young-Kwan Kim1, Vincent M Rotello3.   

Abstract

A nanoparticle design featuring pH-responsive alkoxyphenyl acylsulfonamide ligands is reported herein. As a result of ligand structure, this nanoparticle is neutral at pH 7.4, becoming positively charged at tumor pH (<6.5). The particle uptake and cytotoxicity increase over this pH range. This pH-controlled uptake and toxicity makes this particle a promising tool for tumor selective therapy.
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  antitumor agents; cellular uptake; gold; nanoparticles; zwitterionic ligands

Mesh：

Substances：

Year:  2015        PMID： 25873209      PMCID： PMC4484729          DOI： 10.1002/anie.201411615

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  32 in total

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Authors:  Rosa A Cardone; Valeria Casavola; Stephan J Reshkin
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4.  Acid pH in tumors and its potential for therapeutic exploitation.

Authors:  I F Tannock; D Rotin
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Review 5.  Why do cancers have high aerobic glycolysis?

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Authors:  Rui Hong; Nicholas O Fischer; Ayush Verma; Catherine M Goodman; Todd Emrick; Vincent M Rotello
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9.  Modulating pharmacokinetics, tumor uptake and biodistribution by engineered nanoparticles.

Authors:  Rochelle R Arvizo; Oscar R Miranda; Daniel F Moyano; Chad A Walden; Karuna Giri; Resham Bhattacharya; J David Robertson; Vincent M Rotello; Joel M Reid; Priyabrata Mukherjee
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  35 in total

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3.  Matrix Metalloproteinase-9-Responsive Nanogels for Proximal Surface Conversion and Activated Cellular Uptake.

Authors:  Mallory R Gordon; Bo Zhao; Francesca Anson; Ann Fernandez; Khushboo Singh; Celia Homyak; Mine Canakci; Richard W Vachet; S Thayumanavan
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4.  NeutrAvidin Functionalization of CdSe/CdS Quantum Nanorods and Quantification of Biotin Binding Sites using Biotin-4-Fluorescein Fluorescence Quenching.

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Journal:  Bioconjug Chem       Date:  2016-01-14       Impact factor: 4.774

Review 5.  Nanoparticle design strategies for enhanced anticancer therapy by exploiting the tumour microenvironment.

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6.  Fully Zwitterionic Nanoparticle Antimicrobial Agents through Tuning of Core Size and Ligand Structure.

Authors:  Shuaidong Huo; Ying Jiang; Akash Gupta; Ziwen Jiang; Ryan F Landis; Singyuk Hou; Xing-Jie Liang; Vincent M Rotello
Journal:  ACS Nano       Date:  2016-09-16       Impact factor: 15.881

7.  Using the Power of Organic Synthesis for Engineering the Interactions of Nanoparticles with Biological Systems.

Authors:  Tsukasa Mizuhara; Daniel F Moyano; Vincent M Rotello
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8.  Stimuli-Responsive Programmed Specific Targeting in Nanomedicine.

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9.  Hierarchical Targeting Strategy for Enhanced Tumor Tissue Accumulation/Retention and Cellular Internalization.

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10.  Charge-Switchable Nanozymes for Bioorthogonal Imaging of Biofilm-Associated Infections.

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