Literature DB >> 2586225

Identification of fatty acid amides in human plasma.

E S Arafat1, J W Trimble, R N Andersen, C Dass, D M Desiderio.   

Abstract

A family of five long-chain fatty acid carboxamides has been identified and semi-quantified in human plasma by GC-MS. One saturated and four unsaturated amides were found. Luteal phase plasma from 16 women was studied, and all five of the amides were found in ten of the subjects, but none in the other six. The structure of these endogenous amides was established by comparing their GC and MS characteristics with those of the synthetic amides prepared by ammonolysis of corresponding long-chain fatty acid acyl chlorides.

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Year:  1989        PMID： 2586225     DOI： 10.1016/0024-3205(89)90278-6

Source DB:  PubMed          Journal:  Life Sci        ISSN： 0024-3205            Impact factor:   5.037


  14 in total

Review 1.  Biosynthesis, degradation and pharmacological importance of the fatty acid amides.

Authors:  Emma K Farrell; David J Merkler
Journal:  Drug Discov Today       Date:  2008-04-03       Impact factor: 7.851

2.  Unique allosteric regulation of 5-hydroxytryptamine receptor-mediated signal transduction by oleamide.

Authors:  E A Thomas; M J Carson; M J Neal; J G Sutcliffe
Journal:  Proc Natl Acad Sci U S A       Date:  1997-12-09       Impact factor: 11.205

Review 3.  A hypothesis about the endogenous analogue of general anesthesia.

Authors:  R A Lerner
Journal:  Proc Natl Acad Sci U S A       Date:  1997-12-09       Impact factor: 11.205

4.  Chemical requirements for inhibition of gap junction communication by the biologically active lipid oleamide.

Authors:  D L Boger; J E Patterson; X Guan; B F Cravatt; R A Lerner; N B Gilula
Journal:  Proc Natl Acad Sci U S A       Date:  1998-04-28       Impact factor: 11.205

5.  Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide.

Authors:  D L Boger; H Sato; A E Lerner; M P Hedrick; R A Fecik; H Miyauchi; G D Wilkie; B J Austin; M P Patricelli; B F Cravatt
Journal:  Proc Natl Acad Sci U S A       Date:  2000-05-09       Impact factor: 11.205

Review 6.  Fatty acid amide signaling molecules.

Authors:  Cyrine Ezzili; Katerina Otrubova; Dale L Boger
Journal:  Bioorg Med Chem Lett       Date:  2010-08-13       Impact factor: 2.823

7.  Structural requirements for 5-HT2A and 5-HT1A serotonin receptor potentiation by the biologically active lipid oleamide.

Authors:  D L Boger; J E Patterson; Q Jin
Journal:  Proc Natl Acad Sci U S A       Date:  1998-04-14       Impact factor: 11.205

8.  In vivo evidence that N-oleoylglycine acts independently of its conversion to oleamide.

Authors:  Shalini Chaturvedi; William J Driscoll; Brenda M Elliot; Martha M Faraday; Neil E Grunberg; Gregory P Mueller
Journal:  Prostaglandins Other Lipid Mediat       Date:  2006-10-05       Impact factor: 3.072

9.  Primary fatty acid amide metabolism: conversion of fatty acids and an ethanolamine in N18TG2 and SCP cells.

Authors:  Emma K Farrell; Yuden Chen; Muna Barazanji; Kristen A Jeffries; Felipe Cameroamortegui; David J Merkler
Journal:  J Lipid Res       Date:  2011-11-16       Impact factor: 5.922

10.  Gut-inhabiting Clostridia build human GPCR ligands by conjugating neurotransmitters with diet- and human-derived fatty acids.

Authors:  Fang-Yuan Chang; Piro Siuti; Stephane Laurent; Thomas Williams; Emerson Glassey; Andreas W Sailer; David Benjamin Gordon; Horst Hemmerle; Christopher A Voigt
Journal:  Nat Microbiol       Date:  2021-04-12       Impact factor: 17.745
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