Literature DB >> 25855739

A single amino acid deletion in the matrix protein of porcine reproductive and respiratory syndrome virus confers resistance to a polyclonal swine antibody with broadly neutralizing activity.

Benjamin R Trible1, Luca N Popescu2, Nicholas Monday2, Jay G Calvert3, Raymond R R Rowland2.   

Abstract

Assessment of virus neutralization (VN) activity in 176 pigs infected with porcine reproductive and respiratory syndrome virus (PRRSV) identified one pig with broadly neutralizing activity. A Tyr-10 deletion in the matrix protein provided escape from broad neutralization without affecting homologous neutralizing activity. The role of the Tyr-10 deletion was confirmed through an infectious clone with a Tyr-10 deletion. The results demonstrate differences in the properties and specificities of VN responses elicited during PRRSV infection.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 25855739      PMCID： PMC4474298          DOI： 10.1128/JVI.03287-14

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  38 in total

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Authors:  J J Meulenberg; A P van Nieuwstadt; A van Essen-Zandbergen; J P Langeveld
Journal:  J Virol       Date:  1997-08       Impact factor: 5.103

2.  Molecular assessment of the role of envelope-associated structural proteins in cross neutralization among different PRRS viruses.

Authors:  Won-Il Kim; Kyoung-Jin Yoon
Journal:  Virus Genes       Date:  2008-09-03       Impact factor: 2.332

3.  MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods.

Authors:  Koichiro Tamura; Daniel Peterson; Nicholas Peterson; Glen Stecher; Masatoshi Nei; Sudhir Kumar
Journal:  Mol Biol Evol       Date:  2011-05-04       Impact factor: 16.240

4.  The evolution of porcine reproductive and respiratory syndrome virus: quasispecies and emergence of a virus subpopulation during infection of pigs with VR-2332.

Authors:  R R Rowland; M Steffen; T Ackerman; D A Benfield
Journal:  Virology       Date:  1999-07-05       Impact factor: 3.616

5.  Envelope protein requirements for the assembly of infectious virions of porcine reproductive and respiratory syndrome virus.

Authors:  E H J Wissink; M V Kroese; H A R van Wijk; F A M Rijsewijk; J J M Meulenberg; P J M Rottier
Journal:  J Virol       Date:  2005-10       Impact factor: 5.103

6.  Identification of neutralizing and nonneutralizing epitopes in the porcine reproductive and respiratory syndrome virus GP5 ectodomain.

Authors:  M Ostrowski; J A Galeota; A M Jar; K B Platt; F A Osorio; O J Lopez
Journal:  J Virol       Date:  2002-05       Impact factor: 5.103

7.  GP4 of porcine reproductive and respiratory syndrome virus contains a neutralizing epitope that is susceptible to immunoselection in vitro.

Authors:  Sarah Costers; David J Lefebvre; Jan Van Doorsselaere; Merijn Vanhee; Peter L Delputte; Hans J Nauwynck
Journal:  Arch Virol       Date:  2010-01-07       Impact factor: 2.574

8.  Highly divergent strains of porcine reproductive and respiratory syndrome virus incorporate multiple isoforms of nonstructural protein 2 into virions.

Authors:  Matthew A Kappes; Cathy L Miller; Kay S Faaberg
Journal:  J Virol       Date:  2013-10-02       Impact factor: 5.103

9.  Novel structural protein in porcine reproductive and respiratory syndrome virus encoded by an alternative ORF5 present in all arteriviruses.

Authors:  Craig R Johnson; Theodor F Griggs; Josephine Gnanandarajah; Michael P Murtaugh
Journal:  J Gen Virol       Date:  2011-02-09       Impact factor: 3.891

10.  Phylogenetic analyses of the putative M (ORF 6) and N (ORF 7) genes of porcine reproductive and respiratory syndrome virus (PRRSV): implication for the existence of two genotypes of PRRSV in the U.S.A. and Europe.

Authors:  X J Meng; P S Paul; P G Halbur; M A Lum
Journal:  Arch Virol       Date:  1995       Impact factor: 2.574
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  25 in total

1.  Porcine reproductive and respiratory syndrome virus neutralizing antibodies provide in vivo cross-protection to PRRSV1 and PRRSV2 viral challenge.

Authors:  Sally R Robinson; Michael C Rahe; Diem K Gray; Kyra V Martins; Michael P Murtaugh
Journal:  Virus Res       Date:  2018-02-03       Impact factor: 3.303

2.  Genetic relationships of antibody response, viremia level, and weight gain in pigs experimentally infected with porcine reproductive and respiratory syndrome virus1.

Authors:  Andrew S Hess; Ben R Trible; Melanie K Hess; Raymond R Rowland; Joan K Lunney; Graham S Plastow; Jack C M Dekkers
Journal:  J Anim Sci       Date:  2018-09-07       Impact factor: 3.159

3.  Porcine Reproductive and Respiratory Syndrome Virus Promotes SLA-DR-Mediated Antigen Presentation of Nonstructural Proteins To Evoke a Nonneutralizing Antibody Response In Vivo.

Authors:  Chunyan Wu; Bingjun Shi; Di Yang; Kun Zhang; Jie Li; Jie Wang; Hongliang Liu; Qin Zhao; En-Min Zhou; Yuchen Nan
Journal:  J Virol       Date:  2020-10-14       Impact factor: 5.103

4.  Comparison of host genetic factors influencing pig response to infection with two North American isolates of porcine reproductive and respiratory syndrome virus.

Authors:  Andrew S Hess; Zeenath Islam; Melanie K Hess; Raymond R R Rowland; Joan K Lunney; Andrea Doeschl-Wilson; Graham S Plastow; Jack C M Dekkers
Journal:  Genet Sel Evol       Date:  2016-06-20       Impact factor: 4.297

5.  ORF1a of highly pathogenic PRRS attenuated vaccine virus plays a key role in neutralizing antibody induction in piglets and virus neutralization in vitro.

Authors:  Chaoliang Leng; Wuchao Zhang; Hongliang Zhang; Yunchao Kan; Lunguang Yao; Hongyue Zhai; Mingliang Li; Zhen Li; Chunxiao Liu; Tongqing An; Jinmei Peng; Qian Wang; Yumin Leng; Xuehui Cai; Zhijun Tian; Guangzhi Tong
Journal:  Virol J       Date:  2017-08-22       Impact factor: 4.099

Review 6.  Mechanisms of Adaptive Immunity to Porcine Reproductive and Respiratory Syndrome Virus.

Authors:  Michael C Rahe; Michael P Murtaugh
Journal:  Viruses       Date:  2017-06-13       Impact factor: 5.048

7.  Antigenic and Biological Characterization of ORF2-6 Variants at Early Times Following PRRSV Infection.

Authors:  Alyssa B Evans; Hyelee Loyd; Jenelle R Dunkelberger; Sarah van Tol; Marcus J Bolton; Karin S Dorman; Jack C M Dekkers; Susan Carpenter
Journal:  Viruses       Date:  2017-05-16       Impact factor: 5.048

8.  Chimeric HP-PRRSV2 containing an ORF2-6 consensus sequence induces antibodies with broadly neutralizing activity and confers cross protection against virulent NADC30-like isolate.

Authors:  Nanhua Chen; Shubin Li; Yunfei Tian; Xinshuai Li; Shuai Li; Jixiang Li; Ming Qiu; Zhe Sun; Yanzhao Xiao; Xilin Yan; Hong Lin; Xiuling Yu; Kegong Tian; Shaobin Shang; Jianzhong Zhu
Journal:  Vet Res       Date:  2021-05-27       Impact factor: 3.683

9.  Isolation of Porcine Reproductive and Respiratory Syndrome Virus GP5-Specific, Neutralizing Monoclonal Antibodies From Hyperimmune Sows.

Authors:  Jordan E Young; Cheryl M T Dvorak; Simon P Graham; Michael P Murtaugh
Journal:  Front Immunol       Date:  2021-02-22       Impact factor: 7.561

Review 10.  Improved Vaccine against PRRSV: Current Progress and Future Perspective.

Authors:  Yuchen Nan; Chunyan Wu; Guoqian Gu; Weiyao Sun; Yan-Jin Zhang; En-Min Zhou
Journal:  Front Microbiol       Date:  2017-08-28       Impact factor: 5.640
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