Literature DB >> 25843124

A cluster of lead poisoning among consumers of Ayurvedic medicine.

Laura Breeher1, Marek A Mikulski, Thomas Czeczok, Kathy Leinenkugel, Laurence J Fuortes.   

Abstract

BACKGROUND: Use of alternative medications and herbal remedies is widespread in the United States and across the globe. These traditional medications can be contaminated with toxic metals. Despite several case reports of poisoning from such contamination, the epidemiological data are still limited.
OBJECTIVES: To report on a cluster of lead and mercury toxicity cases in 2011 among a community of adherents of traditional medical practice of Ayurveda.
METHODS: Adherents of Ayurveda were offered heavy metals screening following the identification of the index case.
RESULTS: Forty-six of 115 participants (40%) had elevated blood lead levels (BLLs) of 10 μg/dl or above, with 9.6% of BLLs at or above 50 μg/dl.
CONCLUSIONS: This is the largest cluster of lead and mercury toxicity following use of Ayurvedic supplements described in the literature in the US. Contamination of herbal products is a public health issue of global significance. There are few regulations addressing contamination of "natural" products or supplements.

Entities:  

Keywords:  Ayurvedic medicine; Complementary and alternative medicine; Lead toxicity; Mercury toxicity; Public health response

Mesh:

Substances:

Year:  2015        PMID: 25843124      PMCID: PMC4727589          DOI: 10.1179/2049396715Y.0000000009

Source DB:  PubMed          Journal:  Int J Occup Environ Health        ISSN: 1077-3525


  15 in total

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Authors:  Arvind Chopra; Vijay V Doiphode
Journal:  Med Clin North Am       Date:  2002-01       Impact factor: 5.456

2.  Analysis of dietary supplements for arsenic, cadmium, mercury, and lead using inductively coupled plasma mass spectrometry.

Authors:  Scott P Dolan; David A Nortrup; P Michael Bolger; Stephen G Capar
Journal:  J Agric Food Chem       Date:  2003-02-26       Impact factor: 5.279

Review 3.  The use and safety of non-allopathic Indian medicines.

Authors:  N J Gogtay; H A Bhatt; S S Dalvi; N A Kshirsagar
Journal:  Drug Saf       Date:  2002       Impact factor: 5.606

4.  Lead poisoning associated with ayurvedic medications--five states, 2000-2003.

Authors: 
Journal:  MMWR Morb Mortal Wkly Rep       Date:  2004-07-09       Impact factor: 17.586

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Authors:  Robert B Saper; Stefanos N Kales; Janet Paquin; Michael J Burns; David M Eisenberg; Roger B Davis; Russell S Phillips
Journal:  JAMA       Date:  2004-12-15       Impact factor: 56.272

6.  Ayurvedic medicine: patients in peril from plumbism.

Authors:  Johan van Schalkwyk; James Davidson; Barry Palmer; Virginia Hope
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Journal:  World Health Forum       Date:  1993

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Journal:  JAMA       Date:  1998-11-11       Impact factor: 56.272

9.  Lead, mercury, and arsenic in US- and Indian-manufactured Ayurvedic medicines sold via the Internet.

Authors:  Robert B Saper; Russell S Phillips; Anusha Sehgal; Nadia Khouri; Roger B Davis; Janet Paquin; Venkatesh Thuppil; Stefanos N Kales
Journal:  JAMA       Date:  2008-08-27       Impact factor: 56.272

10.  Ayurvedic lead poisoning: an under-recognized, international problem.

Authors:  Stefanos N Kales; Robert B Saper
Journal:  Indian J Med Sci       Date:  2009-09
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  16 in total

1.  Lead Exposure Influences Serum Biomarkers, Hepatocyte Survival, Bone Marrow Hematopoiesis, and the Reproductive Cycle in Japanese Quails.

Authors:  Damir Suljević; Nejira Handžić; Muhamed Fočak; Ivan Lasić; Faris Sipović; Jasmina Sulejmanović; Sabina Begić; Andi Alijagic
Journal:  Biol Trace Elem Res       Date:  2020-06-30       Impact factor: 3.738

2.  Lead poisoning due to Ayurvedic medicine: how about the risk?

Authors:  Beuy Joob; Viroj Wiwanitkit
Journal:  Int J Occup Environ Health       Date:  2016-05-24

3.  Toxic metals in ayurvedic preparations from a public health lead poisoning cluster investigation.

Authors:  Marek A Mikulski; Michael D Wichman; Donald L Simmons; Anthony N Pham; Valentina Clottey; Laurence J Fuortes
Journal:  Int J Occup Environ Health       Date:  2018-03-12

4.  Are Ayurvedic medications store house of heavy metals?

Authors:  A Bhalla; A K Pannu
Journal:  Toxicol Res (Camb)       Date:  2022-01-15       Impact factor: 3.524

5.  Health Remedies as a Source of Lead, Mercury, and Arsenic Exposure, New York City, 2010-2019.

Authors:  Paromita Hore; Kolapo Alex-Oni; Slavenka Sedlar; Kari Patel; Robert B Saper
Journal:  Am J Public Health       Date:  2022-09       Impact factor: 11.561

6.  Lead poisoning among asymptomatic individuals with a long-term history of opiate use in Golestan Cohort Study.

Authors:  Arash Etemadi; Sanam Hariri; Hossein Hassanian-Moghaddam; Hossein Poustchi; Gholamreza Roshandel; Amaneh Shayanrad; Farin Kamangar; Paolo Boffetta; Paul Brennan; Paul I Dargan; Sanford M Dawsey; Robert L Jones; Neal D Freedman; Reza Malekzadeh; Christian C Abnet
Journal:  Int J Drug Policy       Date:  2022-04-25

7.  Case of acute lead toxicity associated with Ayurvedic supplements.

Authors:  Amelia Breyre; Judith Green-McKenzie
Journal:  BMJ Case Rep       Date:  2016-06-30

Review 8.  Lead toxicity: a review.

Authors:  Ab Latif Wani; Anjum Ara; Jawed Ahmad Usmani
Journal:  Interdiscip Toxicol       Date:  2015-06

9.  Alternative drugs go global: possible lead and/ or mercury intoxication from imported natural health products and a need for scientifically evaluated poisoning monitoring from environmental exposures.

Authors:  Lygia Therese Budnik; Xaver Baur; Volker Harth; Axel Hahn
Journal:  J Occup Med Toxicol       Date:  2016-11-08       Impact factor: 2.646

10.  Scanning the Global Literature.

Authors: 
Journal:  Glob Adv Health Med       Date:  2015-11-01
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