Literature DB >> 25828532

TREM2 enables amyloid β clearance by microglia.

Serge Rivest1.   

Abstract

In a recent paper published in Cell, Wang et al. report that deficiency of triggering receptor expressed on myeloid cells 2 (TREM2) augments amyloid β accumulation and neuronal loss in a mouse model of Alzheimer's disease. TREM2 acts as a signaling receptor involved in innate immunity for the natural clearance of this toxic protein by microglia.

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Year:  2015        PMID： 25828532      PMCID： PMC4423078          DOI： 10.1038/cr.2015.37

Source DB:  PubMed          Journal:  Cell Res        ISSN： 1001-0602            Impact factor:   25.617


  6 in total

Review 1.  Innate immunity in the CNS: redefining the relationship between the CNS and Its environment.

Authors:  Antoine Lampron; Ayman Elali; Serge Rivest
Journal:  Neuron       Date:  2013-04-24       Impact factor: 17.173

2.  Anti-inflammatory signaling in microglia exacerbates Alzheimer's disease-related pathology.

Authors:  Jean-Philippe Michaud; Serge Rivest
Journal:  Neuron       Date:  2015-02-04       Impact factor: 17.173

Review 3.  A deficiency in CCR2+ monocytes: the hidden side of Alzheimer's disease.

Authors:  Gaëlle Naert; Serge Rivest
Journal:  J Mol Cell Biol       Date:  2013-07-26       Impact factor: 6.216

4.  Powerful beneficial effects of macrophage colony-stimulating factor on beta-amyloid deposition and cognitive impairment in Alzheimer's disease.

Authors:  Vincent Boissonneault; Mohammed Filali; Martine Lessard; Jane Relton; Gordon Wong; Serge Rivest
Journal:  Brain       Date:  2009-01-17       Impact factor: 13.501

5.  TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model.

Authors:  Yaming Wang; Marina Cella; Kaitlin Mallinson; Jason D Ulrich; Katherine L Young; Michelle L Robinette; Susan Gilfillan; Gokul M Krishnan; Shwetha Sudhakar; Bernd H Zinselmeyer; David M Holtzman; John R Cirrito; Marco Colonna
Journal:  Cell       Date:  2015-02-26       Impact factor: 41.582

6.  TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models.

Authors:  Taylor R Jay; Crystal M Miller; Paul J Cheng; Leah C Graham; Shane Bemiller; Margaret L Broihier; Guixiang Xu; Daniel Margevicius; J Colleen Karlo; Gregory L Sousa; Anne C Cotleur; Oleg Butovsky; Lynn Bekris; Susan M Staugaitis; James B Leverenz; Sanjay W Pimplikar; Gary E Landreth; Gareth R Howell; Richard M Ransohoff; Bruce T Lamb
Journal:  J Exp Med       Date:  2015-03-02       Impact factor: 14.307
  6 in total
  16 in total

Review 1.  TREM2 variants: new keys to decipher Alzheimer disease pathogenesis.

Authors:  Marco Colonna; Yaming Wang
Journal:  Nat Rev Neurosci       Date:  2016-02-25       Impact factor: 34.870

Review 2.  Dantrolene : From Malignant Hyperthermia to Alzheimer's Disease.

Authors:  Yun Shi; Yong Wang; Huafeng Wei
Journal:  CNS Neurol Disord Drug Targets       Date:  2019       Impact factor: 4.388

3.  Alterations in brain TREM2 and Amyloid-β levels are associated with neurocognitive impairment in HIV-infected persons on antiretroviral therapy.

Authors:  Jerel Adam Fields; Brian Spencer; Mary Swinton; Emma Martine Qvale; María J Marquine; Arina Alexeeva; Sarah Gough; Benchawanna Soontornniyomkij; Elvira Valera; Eliezer Masliah; Cristian L Achim; Paula Desplats
Journal:  J Neurochem       Date:  2018-11-26       Impact factor: 5.372

Review 4.  Sex differences in neurodevelopmental and neurodegenerative disorders: Focus on microglial function and neuroinflammation during development.

Authors:  Richa Hanamsagar; Staci D Bilbo
Journal:  J Steroid Biochem Mol Biol       Date:  2015-10-23       Impact factor: 4.292

Review 5.  Let's make microglia great again in neurodegenerative disorders.

Authors:  Marie-Victoire Guillot-Sestier; Terrence Town
Journal:  J Neural Transm (Vienna)       Date:  2017-10-12       Impact factor: 3.575

6.  Microbiome-generated amyloid and potential impact on amyloidogenesis in Alzheimer's disease (AD).

Authors:  Yuhai Zhao; Walter J Lukiw
Journal:  J Nat Sci       Date:  2015-07

7.  SIRT1-Dependent Upregulation of BDNF in Human Microglia Challenged with Aβ: An Early but Transient Response Rescued by Melatonin.

Authors:  Grazia Ilaria Caruso; Simona Federica Spampinato; Giuseppe Costantino; Sara Merlo; Maria Angela Sortino
Journal:  Biomedicines       Date:  2021-04-24

8.  microRNA-34a-Mediated Down-Regulation of the Microglial-Enriched Triggering Receptor and Phagocytosis-Sensor TREM2 in Age-Related Macular Degeneration.

Authors:  Surjyadipta Bhattacharjee; Yuhai Zhao; Prerna Dua; Evgeny I Rogaev; Walter J Lukiw
Journal:  PLoS One       Date:  2016-03-07       Impact factor: 3.240

Review 9.  Microglia Ontology and Signaling.

Authors:  Ayman ElAli; Serge Rivest
Journal:  Front Cell Dev Biol       Date:  2016-06-29

10.  Dark microglia: A new phenotype predominantly associated with pathological states.

Authors:  Kanchan Bisht; Kaushik P Sharma; Cynthia Lecours; Maria Gabriela Sánchez; Hassan El Hajj; Giampaolo Milior; Adrián Olmos-Alonso; Diego Gómez-Nicola; Giamal Luheshi; Luc Vallières; Igor Branchi; Laura Maggi; Cristina Limatola; Oleg Butovsky; Marie-Ève Tremblay
Journal:  Glia       Date:  2016-02-05       Impact factor: 7.452
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