| Literature DB >> 25654250 |
Jean-Philippe Michaud1, Serge Rivest2.
Abstract
In this issue of Neuron, Chakrabarty et al. (2015) and Guillot-Sestier et al. (2015) reveal that the anti-inflammatory cytokine IL-10 inhibits Aβ clearance by microglia, worsening cognitive decline in mouse models of Alzheimer's disease (AD). These studies provide further support that pro-inflammatory signaling is an innate immune defense mechanism in AD.Entities:
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Year: 2015 PMID： 25654250 DOI： 10.1016/j.neuron.2015.01.021
Source DB: PubMed Journal: Neuron ISSN： 0896-6273 Impact factor: 17.173