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Literature DB >> 29027011

Let's make microglia great again in neurodegenerative disorders.

Marie-Victoire Guillot-Sestier^1,2, Terrence Town³.

Abstract

All of the common neurodegenerative disorders-Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and prion diseases-are characterized by accumulation of misfolded proteins that trigger activation of microglia; brain-resident mononuclear phagocytes. This chronic form of neuroinflammation is earmarked by increased release of myriad cytokines and chemokines in patient brains and biofluids. Microglial phagocytosis is compromised early in the disease process, obfuscating clearance of abnormal proteins. This review identifies immune pathologies shared by the major neurodegenerative disorders. The overarching concept is that aberrant innate immune pathways can be targeted for return to homeostasis in hopes of coaxing microglia into clearing neurotoxic misfolded proteins.

Entities: Disease Species

Keywords: Innate immunity; Microglia; Neurodegenerative diseases; Neuroinflammation; Phagocytosis; Proteinopathy

Mesh：

Year: 2017 PMID： 29027011 PMCID： PMC5897227 DOI： 10.1007/s00702-017-1792-x

Source DB: PubMed Journal: J Neural Transm (Vienna) ISSN： 0300-9564 Impact factor: 3.575

348 in total

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Authors: Toyoko Arimoto; Dong-Young Choi; Xin Lu; Mei Liu; Xuan V Nguyen; Naiying Zheng; Charles A Stewart; Hyoung-Chun Kim; Guoying Bing
Journal: Neurobiol Aging Date: 2007-06 Impact factor: 4.673

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Authors: Brent Cameron; Wayne Tse; Raza Lamb; Xiaoxia Li; Bruce T Lamb; Gary E Landreth
Journal: J Neurosci Date: 2012-10-24 Impact factor: 6.167

4. Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta.

Authors: Ana Griciuc; Alberto Serrano-Pozo; Antonio R Parrado; Andrea N Lesinski; Caroline N Asselin; Kristina Mullin; Basavaraj Hooli; Se Hoon Choi; Bradley T Hyman; Rudolph E Tanzi
Journal: Neuron Date: 2013-04-25 Impact factor: 17.173

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Authors: K Houi; T Kobayashi; S Kato; S Mochio; K Inoue
Journal: Acta Neurol Scand Date: 2002-11 Impact factor: 3.209

6. Investigation of genes coding for inflammatory components in Parkinson's disease.

Authors: Anna Håkansson; Lars Westberg; Staffan Nilsson; Silvia Buervenich; Andrea Carmine; Björn Holmberg; Olof Sydow; Lars Olson; Bo Johnels; Elias Eriksson; Hans Nissbrandt
Journal: Mov Disord Date: 2005-05 Impact factor: 10.338

Review 7. TGF-beta 1 is an organizer of responses to neurodegeneration.

Authors: C E Finch; N J Laping; T E Morgan; N R Nichols; G M Pasinetti
Journal: J Cell Biochem Date: 1993-12 Impact factor: 4.429

8. The influence of AAV2-mediated gene transfer of human IL-10 on neurodegeneration and immune response in a murine model of Parkinson's disease.

Authors: Ilona Joniec-Maciejak; Agnieszka Ciesielska; Adriana Wawer; Anna Sznejder-Pachołek; Joanna Schwenkgrub; Agnieszka Cudna; Piotr Hadaczek; Kristof S Bankiewicz; Anna Członkowska; Andrzej Członkowski
Journal: Pharmacol Rep Date: 2014-04-08 Impact factor: 3.024

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Authors: David A Loeffler; Dianne M Camp; David A Bennett
Journal: J Neuroinflammation Date: 2008-03-11 Impact factor: 8.322

10. alpha-Synuclein and neuronal cell death.

Authors: Mark R Cookson
Journal: Mol Neurodegener Date: 2009-02-04 Impact factor: 14.195

6 in total

1. Megalencephalic Leukoencephalopathy with Subcortical Cysts Protein-1 (MLC1) Counteracts Astrocyte Activation in Response to Inflammatory Signals.

Authors: Maria Stefania Brignone; Angela Lanciotti; Barbara Serafini; Cinzia Mallozzi; Marco Sbriccoli; Caterina Veroni; Paola Molinari; Xabier Elorza-Vidal; Tamara Corinna Petrucci; Raul Estévez; Elena Ambrosini
Journal: Mol Neurobiol Date: 2019-06-17 Impact factor: 5.590