Literature DB >> 2582370

Molecular cloning and characterization of a gene coding for methanol oxidase in Hansenula polymorpha.

A M Ledeboer, L Edens, J Maat, C Visser, J W Bos, C T Verrips, Z Janowicz, M Eckart, R Roggenkamp, C P Hollenberg.   

Abstract

The structural gene and the regulatory DNA sequence of the yeast Hansenula polymorpha methanol oxidase have been isolated. According to the nucleotide sequence data obtained, the structural gene encodes a 664 amino acids long protein, contains no intervening sequences, and the 5'- and 3'-non-coding region contains several sequences implicated in transcription initiation and termination in the yeast Saccharomyces cerevisiae. Although the methanol oxidase is translocated to the peroxisomes, no cleavable signal sequence was found at the N-terminus of the protein.

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Year:  1985        PMID： 2582370      PMCID： PMC341221          DOI： 10.1093/nar/13.9.3063

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  33 in total

1.  The primary structure of D-amino acid oxidase from pig kidney. II. Isolation and sequence of overlap peptides and the complete sequence.

Authors:  S Ronchi; L Minchiotti; M Galliano; B Curti; R P Swenson; C H Williams; V Massey
Journal:  J Biol Chem       Date:  1982-08-10       Impact factor: 5.157

2.  Cloning of the natural gene for the sweet-tasting plant protein thaumatin.

Authors:  A M Ledeboer; C T Verrips; B M Dekker
Journal:  Gene       Date:  1984-10       Impact factor: 3.688

3.  Nucleotide sequence of yeast LEU2 shows 5'-noncoding region has sequences cognate to leucine.

Authors:  A Andreadis; Y P Hsu; G B Kohlhaw; P Schimmel
Journal:  Cell       Date:  1982-12       Impact factor: 41.582

4.  Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomes.

Authors:  M Kozak
Journal:  Nucleic Acids Res       Date:  1981-10-24       Impact factor: 16.971

5.  Biosynthesis and regulation of the peroxisomal methanol oxidase from the methylotrophic yeast Hansenula polymorpha.

Authors:  R Roggenkamp; Z Janowicz; B Stanikowski; C P Hollenberg
Journal:  Mol Gen Genet       Date:  1984

6.  DNA sequence required for efficient transcription termination in yeast.

Authors:  K S Zaret; F Sherman
Journal:  Cell       Date:  1982-03       Impact factor: 41.582

7.  The transcriptional regulation of Xenopus 5s RNA genes in chromatin: the roles of active stable transcription complexes and histone H1.

Authors:  M S Schlissel; D D Brown
Journal:  Cell       Date:  1984-07       Impact factor: 41.582

8.  Chicken ovalbumin contains an internal signal sequence.

Authors:  V R Lingappa; J R Lingappa; G Blobel
Journal:  Nature       Date:  1979-09-13       Impact factor: 49.962

9.  The nucleotide sequence of the yeast PHO5 gene: a putative precursor of repressible acid phosphatase contains a signal peptide.

Authors:  K Arima; T Oshima; I Kubota; N Nakamura; T Mizunaga; A Toh-e
Journal:  Nucleic Acids Res       Date:  1983-03-25       Impact factor: 16.971

10.  The use of synthetic oligonucleotides as hybridization probes. II. Hybridization of oligonucleotides of mixed sequence to rabbit beta-globin DNA.

Authors:  R B Wallace; M J Johnson; T Hirose; T Miyake; E H Kawashima; K Itakura
Journal:  Nucleic Acids Res       Date:  1981-02-25       Impact factor: 16.971
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  48 in total

Review 1.  Import of proteins into peroxisomes and other microbodies.

Authors:  M J de Hoop; G Ab
Journal:  Biochem J       Date:  1992-09-15       Impact factor: 3.857

2.  Formation of irregular giant peroxisomes by overproduction of the crystalloid core protein methanol oxidase in the methylotrophic yeast Hansenula polymorpha.

Authors:  R Roggenkamp; T Didion; K V Kowallik
Journal:  Mol Cell Biol       Date:  1989-03       Impact factor: 4.272

3.  Architecture of peroxisomal alcohol oxidase crystals from the methylotrophic yeast Hansenula polymorpha as deduced by electron microscopy.

Authors:  J Vonck; E F van Bruggen
Journal:  J Bacteriol       Date:  1992-08       Impact factor: 3.490

4.  Crystallization of alcohol oxidase from Pichia pastoris. Secondary structure predictions indicate a domain with the eightfold beta/alpha-barrel fold.

Authors:  E Tykarska; L Lebioda; E Marchut; J Steczko; B Stec
Journal:  J Protein Chem       Date:  1990-02

5.  Fast repair of O6-ethylguanine, but not O6-methylguanine, in transcribed genes prevents mutation of H-ras in rat mammary tumorigenesis induced by ethylnitrosourea in place of methylnitrosourea.

Authors:  J Engelbergs; J Thomale; A Galhoff; M F Rajewsky
Journal:  Proc Natl Acad Sci U S A       Date:  1998-02-17       Impact factor: 11.205

6.  A regulatory mutant of Hansenula polymorpha exhibiting methanol utilization metabolism and peroxisome proliferation in glucose.

Authors:  G Parpinello; E Berardi; R Strabbioli
Journal:  J Bacteriol       Date:  1998-06       Impact factor: 3.490

7.  Biosynthesis of the peroxisomal dihydroxyacetone synthase from Hansenula polymorpha in Saccharomyces cerevisiae induces growth but not proliferation of peroxisomes.

Authors:  A Gödecke; M Veenhuis; R Roggenkamp; Z A Janowicz; C P Hollenberg
Journal:  Curr Genet       Date:  1989-07       Impact factor: 3.886

8.  The methylotrophic yeast Hansenula polymorpha contains an inducible import pathway for peroxisomal matrix proteins with an N-terminal targeting signal (PTS2 proteins).

Authors:  K N Faber; P Haima; C Gietl; W Harder; G Ab; M Veenhuis
Journal:  Proc Natl Acad Sci U S A       Date:  1994-12-20       Impact factor: 11.205

9.  Crystal structure of p-hydroxybenzoate hydroxylase reconstituted with the modified FAD present in alcohol oxidase from methylotrophic yeasts: evidence for an arabinoflavin.

Authors:  W J van Berkel; M H Eppink; H A Schreuder
Journal:  Protein Sci       Date:  1994-12       Impact factor: 6.725

10.  The positive and negative cis-acting elements for methanol regulation in the Pichia pastoris AOX2 gene.

Authors:  H Ohi; M Miura; R Hiramatsu; T Ohmura
Journal:  Mol Gen Genet       Date:  1994-06-03
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