| Literature DB >> 25818235 |
Alexander Bürkle1, María Moreno-Villanueva2, Jürgen Bernhard3, María Blasco4, Gerben Zondag5, Jan H J Hoeijmakers6, Olivier Toussaint7, Beatrix Grubeck-Loebenstein8, Eugenio Mocchegiani9, Sebastiano Collino10, Efstathios S Gonos11, Ewa Sikora12, Daniela Gradinaru13, Martijn Dollé14, Michel Salmon15, Peter Kristensen16, Helen R Griffiths17, Claude Libert18, Tilman Grune19, Nicolle Breusing20, Andreas Simm21, Claudio Franceschi22, Miriam Capri22, Duncan Talbot23, Paola Caiafa24, Bertrand Friguet25, P Eline Slagboom26, Antti Hervonen27, Mikko Hurme27, Richard Aspinall28.
Abstract
Many candidate biomarkers of human ageing have been proposed in the scientific literature but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has proven to serve a useful marker to determine, on its own, biological age. A plausible reason for this is the intrinsic multi-causal and multi-system nature of the ageing process. The recently completed MARK-AGE study was a large-scale integrated project supported by the European Commission. The major aim of this project was to conduct a population study comprising about 3200 subjects in order to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation.Entities:
Keywords: Ageing biomarkers; Human studies; MARK-AGE
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Year: 2015 PMID： 25818235 DOI： 10.1016/j.mad.2015.03.006
Source DB: PubMed Journal: Mech Ageing Dev ISSN： 0047-6374 Impact factor: 5.432