Literature DB >> 29671037

[Geriatric intensive care patients : Perspectives and limits of geriatric intensive care medicine].

U Müller-Werdan1, H-J Heppner2, G Michels3.   

Abstract

Critically ill geriatric patients are vitally endangered due to the aging processes of organs, the frequently existing multimorbidity with subsequent polypharmacy and the typical geriatric syndrome of functional impairments. Aging processes in organs lower the clinical threshold for organ dysfunction and organ failure. Physiological organ aging processes with practical consequences for intensive care medicine are atypical manifestion of sepsis in immunosenescence, altered pharmacokinetics, reduced tolerance to hypovolemia due to proportionally reduced water compartment of the body in old age, the frequently only apparently normal function of the kidneys and the continuous reduction in pulmonary function in old age. The main reasons for changes in therapeutic targets are the will of the patient and risk-benefit considerations. The guidelines of the ethics section of the German Interdisciplinary Association for Intensive Care and Emergency Medicine (DIVI) provide assistance and suggestions for a structured decision-making process.

Entities:  

Keywords:  Aging; Biomarkers; End of life care; Frailty; Intensive care

Mesh:

Year:  2018        PMID: 29671037     DOI: 10.1007/s00063-018-0440-z

Source DB:  PubMed          Journal:  Med Klin Intensivmed Notfmed        ISSN: 2193-6218            Impact factor:   0.840


  16 in total

Review 1.  [Medical geriatric aspects in intensive care therapy of elderly patients].

Authors:  U Müller-Werdan; T Klöss; M Meisel
Journal:  Med Klin Intensivmed Notfmed       Date:  2011-10-07       Impact factor: 0.840

Review 2.  Physiology Considerations in Geriatric Patients.

Authors:  Bret D Alvis; Christopher G Hughes
Journal:  Anesthesiol Clin       Date:  2015-07-03

Review 3.  MARK-AGE biomarkers of ageing.

Authors:  Alexander Bürkle; María Moreno-Villanueva; Jürgen Bernhard; María Blasco; Gerben Zondag; Jan H J Hoeijmakers; Olivier Toussaint; Beatrix Grubeck-Loebenstein; Eugenio Mocchegiani; Sebastiano Collino; Efstathios S Gonos; Ewa Sikora; Daniela Gradinaru; Martijn Dollé; Michel Salmon; Peter Kristensen; Helen R Griffiths; Claude Libert; Tilman Grune; Nicolle Breusing; Andreas Simm; Claudio Franceschi; Miriam Capri; Duncan Talbot; Paola Caiafa; Bertrand Friguet; P Eline Slagboom; Antti Hervonen; Mikko Hurme; Richard Aspinall
Journal:  Mech Ageing Dev       Date:  2015-03-24       Impact factor: 5.432

Review 4.  [Documentation of decisions to withhold or withdraw life-sustaining therapies : Recommendation of the Ethics Section of the German Interdisciplinary Association of Critical Care and Emergency Medicine (DIVI) in collaboration with the Ethics Section of the German Society for Medical Intensive Care and Emergency Medicine (DGIIN)].

Authors:  G Neitzke; B Böll; H Burchardi; K Dannenberg; G Duttge; R Erchinger; P Gretenkort; C Hartog; K Knochel; M Liebig; A Michalsen; G Michels; M Mohr; F Nauck; P Radke; F Salomon; H Stopfkuchen; U Janssens
Journal:  Med Klin Intensivmed Notfmed       Date:  2017-09       Impact factor: 0.840

5.  Advance Directives and Powers of Attorney in Intensive Care Patients.

Authors:  Geraldine de Heer; Bernd Saugel; Barbara Sensen; Charlotte Rübsteck; Hans O Pinnschmidt; Stefan Kluge
Journal:  Dtsch Arztebl Int       Date:  2017-06-05       Impact factor: 5.594

6.  [Difficult decisions in end-of-life situations : An important team task].

Authors:  U Janssens; B Böll; H Burchardi; K Dannenberg; G Duttge; R Erchinger; P Gretenkort; C Hartog; K Knochel; M Liebig; A Michalsen; G Michels; M Mohr; F Nauck; P Radke; F Salomon; H Stopfkuchen; G Neitzke
Journal:  Med Klin Intensivmed Notfmed       Date:  2017-10       Impact factor: 0.840

Review 7.  Molecular and biological hallmarks of ageing.

Authors:  J R Aunan; M M Watson; H R Hagland; K Søreide
Journal:  Br J Surg       Date:  2016-01       Impact factor: 6.939

Review 8.  Assessing inflammageing.

Authors:  Ursula Müller-Werdan; Sebastian Nuding; Mario Ost
Journal:  Curr Opin Clin Nutr Metab Care       Date:  2017-09       Impact factor: 4.294

Review 9.  Molecular and physiological manifestations and measurement of aging in humans.

Authors:  Sadiya S Khan; Benjamin D Singer; Douglas E Vaughan
Journal:  Aging Cell       Date:  2017-05-23       Impact factor: 9.304

Review 10.  The impact of frailty on intensive care unit outcomes: a systematic review and meta-analysis.

Authors:  John Muscedere; Braden Waters; Aditya Varambally; Sean M Bagshaw; J Gordon Boyd; David Maslove; Stephanie Sibley; Kenneth Rockwood
Journal:  Intensive Care Med       Date:  2017-07-04       Impact factor: 17.440

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  3 in total

Review 1.  [Core curriculum Medical intensive care medicine of the German Society of Medical Intensive Care and Emergency Medicine (DGIIN)].

Authors:  S John; R Riessen; C Karagiannidis; U Janssens; H-J Busch; M Kochanek; G Michels; C Hermes; M Buerke; S Kluge; M Baumgärtel; S Braune; F Erbguth; V Fuhrmann; P Lebiedz; K Mayer; U Müller-Werdan; M Oppert; F Sayk; D Sedding; C Willam; K Werdan
Journal:  Med Klin Intensivmed Notfmed       Date:  2021-01-11       Impact factor: 0.840

2.  Intensive care of geriatric patients-a thin line between under- and overtreatment.

Authors:  Hans Jürgen Heppner; Hag Haitham
Journal:  Wien Med Wochenschr       Date:  2022-01-10

Review 3.  [Geriatric patients in the intensive care unit].

Authors:  S Schmid; K Heissner; S Schlosser; M Müller-Schilling
Journal:  Gastroenterologe       Date:  2021-07-30
  3 in total

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