P Di Bonito1, G Valerio2, G Grugni3, M R Licenziati4, C Maffeis5, M Manco6, E Miraglia del Giudice7, L Pacifico8, M C Pellegrin9, M Tomat10, M G Baroni11. 1. Department of Internal Medicine, Pozzuoli Hospital (Napoli), Naples, Italy. 2. Department of Movement Sciences and Wellness, Parthenope University, Naples, Italy. Electronic address: giuliana.valerio@uniparthenope.it. 3. Division of Auxology, Italian Auxological Institute, Verbania, Italy. 4. Department of Pediatrics, AORN Santobono-Pausilipon, Naples, Italy. 5. Pediatric Diabetes and Metabolic Disorders Unit, Department of Life & Reproduction Sciences, University of Verona, Verona, Italy. 6. Bambino Gesù Children's Hospital, Rome, Italy. 7. Department of Woman, Child and General and Specialized Surgery, Second University of Napoli, Naples, Italy. 8. Department of Pediatrics and Child Neuropsychiatry, Sapienza University of Rome, Rome, Italy. 9. Department of Pediatrics, University of Trieste, Trieste, Italy. 10. Pediatric Unity, AOU Udine, Udine, Italy. 11. Endocrinology and Diabetes, Department of Medical Sciences, University of Cagliari, Cagliari, Italy; Department of Experimental Medicine, Sapienza University of Roma, Rome, Italy.
Abstract
BACKGROUND AND AIMS: Lipid ratios to estimate atherosclerotic disease risk in overweight/obese children are receiving great attention. We aimed to compare the performance of non-high-density lipoprotein-cholesterol (HDL-C) versus triglycerides-to-HDL-C ratio (Tg/HDL-C) in identifying cardiometabolic risk factors (CMRFs) or preclinical signs of organ damage in outpatient Italian overweight/obese children. METHODS AND RESULTS: In this retrospective, cross-sectional study, 5505 children (age 5-18 years) were recruited from 10 Italian centers for the care of obesity, of which 4417 (78%) showed obesity or morbid obesity. Anthropometric, biochemical, and blood pressure variables were analyzed in all children. Liver ultrasound scan, carotid artery ultrasound, and echocardiography were performed in 1257, 601, and 252 children, respectively. The entire cohort was divided based on the 75th percentile of non-HDL-C (≥130 mg/dl) or Tg/HDL-C ratio (≥2.2). The odds ratio for insulin resistance, high blood pressure, metabolic syndrome, presence of liver steatosis, increased levels of carotid intima-media thickness (cIMT) and concentric left ventricular hypertrophy (cLVH) was higher in children with high levels of Tg/HDL-C with respect to children with high levels of non-HDL-C. CONCLUSIONS: In an outpatient setting of overweight/obese children, Tg/HDL-C ratio discriminated better than non-HDL-C children with CMRFs or preclinical signs of liver steatosis, and increased cIMT and cLVH.
BACKGROUND AND AIMS: Lipid ratios to estimate atherosclerotic disease risk in overweight/obesechildren are receiving great attention. We aimed to compare the performance of non-high-density lipoprotein-cholesterol (HDL-C) versus triglycerides-to-HDL-C ratio (Tg/HDL-C) in identifying cardiometabolic risk factors (CMRFs) or preclinical signs of organ damage in outpatient Italian overweight/obesechildren. METHODS AND RESULTS: In this retrospective, cross-sectional study, 5505 children (age 5-18 years) were recruited from 10 Italian centers for the care of obesity, of which 4417 (78%) showed obesity or morbid obesity. Anthropometric, biochemical, and blood pressure variables were analyzed in all children. Liver ultrasound scan, carotid artery ultrasound, and echocardiography were performed in 1257, 601, and 252 children, respectively. The entire cohort was divided based on the 75th percentile of non-HDL-C (≥130 mg/dl) or Tg/HDL-C ratio (≥2.2). The odds ratio for insulin resistance, high blood pressure, metabolic syndrome, presence of liver steatosis, increased levels of carotid intima-media thickness (cIMT) and concentric left ventricular hypertrophy (cLVH) was higher in children with high levels of Tg/HDL-C with respect to children with high levels of non-HDL-C. CONCLUSIONS: In an outpatient setting of overweight/obesechildren, Tg/HDL-C ratio discriminated better than non-HDL-C children with CMRFs or preclinical signs of liver steatosis, and increased cIMT and cLVH.
Authors: P Di Bonito; L Pacifico; C Chiesa; G Valerio; E Miraglia Del Giudice; C Maffeis; A Morandi; C Invitti; M R Licenziati; S Loche; G Tornese; F Franco; M Manco; M G Baroni Journal: J Endocrinol Invest Date: 2016-11-16 Impact factor: 4.256
Authors: M L Marcovecchio; M Bagordo; E Marisi; T de Giorgis; V Chiavaroli; F Chiarelli; A Mohn Journal: J Endocrinol Invest Date: 2017-03-01 Impact factor: 4.256