P Di Bonito1, L Pacifico2, C Chiesa3, G Valerio4, E Miraglia Del Giudice5, C Maffeis6, A Morandi6, C Invitti7, M R Licenziati8, S Loche9, G Tornese10, F Franco11, M Manco12, M G Baroni13,14. 1. Department of Internal Medicine, "S. Maria delle Grazie", Pozzuoli Hospital, Naples, Italy. 2. Policlinico Umberto I Hospital, Sapienza University of Rome, 00161, Rome, Italy. lucia.pacifico@uniroma1.it. 3. Institute of Translational Pharmacology, National Research Council, Rome, Italy. 4. Department of Movement and Wellness Sciences, Parthenope University, Naples, Italy. 5. Department of Woman, Child and General and Specialized Surgery, Second University of Naples, Naples, Italy. 6. Pediatric Diabetes and Metabolic Disorders Unit, University of Verona, Verona, Italy. 7. Department of Medical Sciences and Rehabilitation, IRCCS Istituto Auxologico Italiano, Milan, Italy. 8. Department of Pediatrics, AORN Santobono-Pausilipon, Naples, Italy. 9. Pediatric Endocrine Unit, Regional Hospital for Microcitemia, Cagliari, Italy. 10. Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy. 11. Pediatric Unity, AOU Udine, Udine, Italy. 12. IRCCS Bambino Gesù Children's Hospital, Rome, Italy. 13. Department of Medical Sciences, University of Cagliari, Cagliari, Italy. 14. Endocrinology, Department Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Abstract
OBJECTIVE: To investigate in a large sample of overweight/obese (OW/OB) children and adolescents the prevalence of prediabetic phenotypes such as impaired fasting glucose (IFG) and impaired glucose tolerance (IGT), and to assess their association with cardiometabolic risk (CMR) factors including hepatic steatosis (HS). METHODS: Population data were obtained from the CARdiometabolic risk factors in children and adolescents in ITALY study. Between 2003 and 2013, 3088 youths (972 children and 2116 adolescents) received oral glucose tolerance test (OGTT) and were included in the study. In 798 individuals, abdominal ultrasound for identification of HS was available. RESULTS: The prevalence of IFG (3.2 vs. 3.3%) and IGT (4.6 vs. 5.0%) was similar between children and adolescents. Children with isolated IGT had a 2-11 fold increased risk of high LDL-C, non-HDL-C, Tg/HDL-C ratio, and low insulin sensitivity, when compared to those with normal glucose tolerance (NGT). No significant association of IFG with any CMR factor was found in children. Among adolescents, IGT subjects, and to a lesser extent those with IFG, showed a worse CMR profile compared to NGT subgroup. In the overall sample, IGT phenotype showed a twofold increased risk of HS compared to NGT subgroup. CONCLUSIONS: Our study shows an unexpected similar prevalence of IFG and IGT between children and adolescents with overweight/obesity. The IGT phenotype was associated with a worse CMR profile in both children and adolescents. Phenotyping prediabetes conditions by OGTT should be done as part of prediction and prevention of cardiometabolic diseases in OW/OB youth since early childhood.
OBJECTIVE: To investigate in a large sample of overweight/obese (OW/OB) children and adolescents the prevalence of prediabetic phenotypes such as impaired fasting glucose (IFG) and impaired glucose tolerance (IGT), and to assess their association with cardiometabolic risk (CMR) factors including hepatic steatosis (HS). METHODS: Population data were obtained from the CARdiometabolic risk factors in children and adolescents in ITALY study. Between 2003 and 2013, 3088 youths (972 children and 2116 adolescents) received oral glucose tolerance test (OGTT) and were included in the study. In 798 individuals, abdominal ultrasound for identification of HS was available. RESULTS: The prevalence of IFG (3.2 vs. 3.3%) and IGT (4.6 vs. 5.0%) was similar between children and adolescents. Children with isolated IGT had a 2-11 fold increased risk of high LDL-C, non-HDL-C, Tg/HDL-C ratio, and low insulin sensitivity, when compared to those with normal glucose tolerance (NGT). No significant association of IFG with any CMR factor was found in children. Among adolescents, IGT subjects, and to a lesser extent those with IFG, showed a worse CMR profile compared to NGT subgroup. In the overall sample, IGT phenotype showed a twofold increased risk of HS compared to NGT subgroup. CONCLUSIONS: Our study shows an unexpected similar prevalence of IFG and IGT between children and adolescents with overweight/obesity. The IGT phenotype was associated with a worse CMR profile in both children and adolescents. Phenotyping prediabetes conditions by OGTT should be done as part of prediction and prevention of cardiometabolic diseases in OW/OB youth since early childhood.
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Authors: Florian Koutny; Daniel Weghuber; E Bollow; S Greber-Platzer; K Hartmann; A Körner; T Reinehr; M Roebl; G Simic-Schleicher; M Wabitsch; K Widhalm; S Wiegand; R W Holl Journal: Pediatr Obes Date: 2019-12-06 Impact factor: 4.000
Authors: Ming Li; Shan Gao; Yu Li; Dan Feng; Issy C Esangbedo; Yanglu Zhao; Lanwen Han; Yingna Zhu; Junling Fu; Ge Li; Dongmei Wang; Yonghui Wang; Steven M Willi Journal: BMJ Open Diabetes Res Care Date: 2020-02