| Literature DB >> 25811298 |
Christian Perez1, Jean-Philippe Monserrat, Yao Chen, Seth M Cohen.
Abstract
A novel approach for developing prodrugs based on masked carboxylic acids is described. Rather than using conventional esterase-based activation, thiazolidinone protecting groups have been identified that can reveal carboxylic acid groups upon activation by hydrogen peroxide. This may prove valuable in the continuing development of prodrug strategies that rely on reactive oxygen species (ROS) as a trigger.Entities:
Mesh：
Substances：
Year: 2015 PMID： 25811298 PMCID： PMC4659858 DOI： 10.1039/c4cc09921d
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222