Literature DB >> 7821417

Persistent oxidative stress in cancer.

S Toyokuni1, K Okamoto, J Yodoi, H Hiai.   

Abstract

DNA of cancers such as renal cell carcinoma and mammary invasive ductal carcinoma, is persistently exposed to more oxidative stress than that of adjacent normal tissue. We suggest that the concept of 'persistent oxidative stress in cancer' may open up a new research area, explaining part of the characteristic tumor biology of cancer such as activated transcription factors and proto-oncogenes, genomic instability, chemotherapy-resistance, invasion and metastasis.

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Year:  1995        PMID： 7821417     DOI： 10.1016/0014-5793(94)01368-b

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  298 in total

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