Bernd Kowall1,2, Birte Holtfreter3, Henry Völzke4, Sabine Schipf4, Torsten Mundt5, Wolfgang Rathmann1, Thomas Kocher3. 1. German Diabetes Center, Institute of Biometrics and Epidemiology, Düsseldorf, Germany. 2. Center of Clinical Epidemiology, c/o Institute of Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital, Essen, Germany. 3. Unit of Periodontology, Department of Restorative Dentistry, Periodontology, and Endodontology, University Medicine, Ernst-Moritz-Arndt-University, Greifswald, Germany. 4. Institute for Community Medicine, University Medicine, Ernst-Moritz-Arndt-University, Greifswald, Germany; 5. Department of Prosthodontics, Gerodontology and Biomaterials, Dental School, University Medicine, Ernst-Moritz-Arndt-University, Greifswald, Germany.
Abstract
AIM: To examine associations of pre-diabetes and well-controlled diabetes with periodontitis. MATERIALS AND METHODS: The Study of Health in Pomerania (SHIP)-Trend is a cross-sectional survey in North-Eastern Germany including 3086 participants (49.4% men; age 20-82 years). Clinical attachment loss (CAL) and periodontal probing depth (PPD) were assessed applying a random half-mouth protocol. The number of teeth was determined. Pre-diabetes comprised impaired fasting glucose and impaired glucose tolerance. Previously known diabetes was defined as well controlled if glycated haemoglobin (HbA1c) was <7.0%. Participants were categorized as follows: normal glucose tolerance (NGT), pre-diabetes, newly detected type 2 diabetes (T2DM), known T2DM with HbA1c<7.0% and known T2DM with HbA1c≥7.0%. RESULTS: Pre-diabetes was neither associated with mean CAL and PPD in multivariable adjusted linear regression models nor with edentulism (OR = 1.09 (95%-CI: 0.69-1.71)) and number of teeth (OR = 0.96 (95%-CI: 0.75-1.22), lowest quartile versus higher quartiles) in logistic regression models. Associations with mean CAL and edentulism were stronger in poorly controlled previously known diabetes than in well-controlled previously known diabetes (for edentulism: OR = 2.19 (95%-CI: 1.18-4.05), and OR = 1.40 (95%-CI: 0.82-2.38), respectively, for comparison with NGT). CONCLUSIONS: Periodontitis and edentulism were associated with poorly controlled T2DM, but not with pre-diabetes and well-controlled diabetes.
AIM: To examine associations of pre-diabetes and well-controlled diabetes with periodontitis. MATERIALS AND METHODS: The Study of Health in Pomerania (SHIP)-Trend is a cross-sectional survey in North-Eastern Germany including 3086 participants (49.4% men; age 20-82 years). Clinical attachment loss (CAL) and periodontal probing depth (PPD) were assessed applying a random half-mouth protocol. The number of teeth was determined. Pre-diabetes comprised impaired fasting glucose and impaired glucose tolerance. Previously known diabetes was defined as well controlled if glycated haemoglobin (HbA1c) was <7.0%. Participants were categorized as follows: normal glucose tolerance (NGT), pre-diabetes, newly detected type 2 diabetes (T2DM), known T2DM with HbA1c<7.0% and known T2DM with HbA1c≥7.0%. RESULTS: Pre-diabetes was neither associated with mean CAL and PPD in multivariable adjusted linear regression models nor with edentulism (OR = 1.09 (95%-CI: 0.69-1.71)) and number of teeth (OR = 0.96 (95%-CI: 0.75-1.22), lowest quartile versus higher quartiles) in logistic regression models. Associations with mean CAL and edentulism were stronger in poorly controlled previously known diabetes than in well-controlled previously known diabetes (for edentulism: OR = 2.19 (95%-CI: 1.18-4.05), and OR = 1.40 (95%-CI: 0.82-2.38), respectively, for comparison with NGT). CONCLUSIONS:Periodontitis and edentulism were associated with poorly controlled T2DM, but not with pre-diabetes and well-controlled diabetes.
Authors: Dara M Shearer; W Murray Thomson; Jonathan M Broadbent; Jim Mann; Richie Poulton Journal: J Clin Periodontol Date: 2016-12-05 Impact factor: 8.728
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