Cynthia M Pérez1, Francisco Muñoz2, Oelisoa M Andriankaja2, Christine S Ritchie3, Sasha Martínez2, José Vergara2, José Vivaldi4, Lydia López4, Maribel Campos2, Kaumudi J Joshipura2,5. 1. Department of Biostatistics and Epidemiology, Graduate School of Public Health, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico. 2. Center for Clinical Research and Health Promotion, School of Dental Medicine, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico. 3. San Francisco Veterans Affairs Medical Center, Center for Research on Aging at the Jewish Home of San Francisco, San Francisco, CA, USA. 4. School of Dental Medicine, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico. 5. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Cambridge, MA, USA.
Abstract
AIM: This study assessed the associations of pre-diabetes and insulin resistance with bleeding on probing (BOP) and periodontitis among adults. MATERIALS AND METHODS: We included 1191 Hispanic adults aged 40-65 years, free of diabetes, enrolled in San Juan Overweight Adults Longitudinal Study. Pre-diabetes was defined as impaired fasting glucose (IFG), impaired glucose tolerance (IGT), or impaired glycated haemoglobin. Impaired one-hour plasma glucose (1hPG) was defined as levels >155 mg/dl. Insulin resistance was defined using the study population-specific 75th percentile (HOMA-IR ≥ 3.13). High BOP was defined as percentage of teeth with bleeding ≥30%. Periodontitis was defined according to the CDC/AAP definition. RESULTS: After multivariable adjustment for age, gender, education, smoking status, alcohol consumption, physical activity, obesity, HDL-C, and plaque index, pre-diabetes with and without 1hPG, IFG, impaired 1hPG, IGT, and HOMA-IR were significantly associated with high BOP; pre-diabetes, IFG, and impaired 1hPG were significantly associated with severe periodontitis. Most of these associations remained significant when the analyses were restricted to non-smokers. CONCLUSIONS: This study suggests associations between pre-diabetes and insulin resistance with BOP and periodontitis. Given the high prevalence of impaired glucose metabolism and periodontitis, the assessment of the temporal sequence of these associations is of utmost importance.
AIM: This study assessed the associations of pre-diabetes and insulin resistance with bleeding on probing (BOP) and periodontitis among adults. MATERIALS AND METHODS: We included 1191 Hispanic adults aged 40-65 years, free of diabetes, enrolled in San Juan Overweight Adults Longitudinal Study. Pre-diabetes was defined as impaired fasting glucose (IFG), impaired glucose tolerance (IGT), or impaired glycated haemoglobin. Impaired one-hour plasma glucose (1hPG) was defined as levels >155 mg/dl. Insulin resistance was defined using the study population-specific 75th percentile (HOMA-IR ≥ 3.13). High BOP was defined as percentage of teeth with bleeding ≥30%. Periodontitis was defined according to the CDC/AAP definition. RESULTS: After multivariable adjustment for age, gender, education, smoking status, alcohol consumption, physical activity, obesity, HDL-C, and plaque index, pre-diabetes with and without 1hPG, IFG, impaired 1hPG, IGT, and HOMA-IR were significantly associated with high BOP; pre-diabetes, IFG, and impaired 1hPG were significantly associated with severe periodontitis. Most of these associations remained significant when the analyses were restricted to non-smokers. CONCLUSIONS: This study suggests associations between pre-diabetes and insulin resistance with BOP and periodontitis. Given the high prevalence of impaired glucose metabolism and periodontitis, the assessment of the temporal sequence of these associations is of utmost importance.
Authors: B Noack; I Jachmann; S Roscher; L Sieber; S Kopprasch; C Lück; M Hanefeld; T Hoffmann Journal: J Periodontol Date: 2000-06 Impact factor: 6.993
Authors: Ryan T Demmer; Moïse Desvarieux; Birte Holtfreter; David R Jacobs; Henri Wallaschofski; Matthias Nauck; Henry Völzke; Thomas Kocher Journal: Diabetes Care Date: 2010-02-25 Impact factor: 19.112
Authors: Petra Timonen; Tuomas Saxlin; Matti Knuuttila; Anna Liisa Suominen; Antti Jula; Tellervo Tervonen; Pekka Ylöstalo Journal: J Clin Periodontol Date: 2013-12 Impact factor: 8.728
Authors: Oelisoa M Andriankaja; James J Jiménez; Francisco J Muñoz-Torres; Cynthia M Pérez; José L Vergara; Kaumudi J Joshipura Journal: J Clin Periodontol Date: 2015-12-11 Impact factor: 8.728
Authors: Nidhi Arora; Panos N Papapanou; Michael Rosenbaum; David R Jacobs; Moïse Desvarieux; Ryan T Demmer Journal: J Clin Periodontol Date: 2014-05-25 Impact factor: 8.728
Authors: Youn-Hee Choi; Robert E McKeown; Elizabeth J Mayer-Davis; Angela D Liese; Keun-Bae Song; Anwar T Merchant Journal: Diabetes Care Date: 2011-01-07 Impact factor: 19.112
Authors: Oelisoa M Andriankaja; Francisco J Muñoz-Torres; José Vivaldi-Oliver; Brian G Leroux; Maribel Campos; Kaumudi Joshipura; Cynthia M Pérez Journal: J Periodontol Date: 2018-05 Impact factor: 6.993
Authors: Kaumudi J Joshipura; Francisco J Muñoz-Torres; Bruce A Dye; Brian G Leroux; Margarita Ramírez-Vick; Cynthia M Pérez Journal: Diabetes Res Clin Pract Date: 2018-04-19 Impact factor: 5.602
Authors: Danielle E Haslam; Liming Liang; Dong D Wang; Rachel S Kelly; Clemens Wittenbecher; Cynthia M Pérez; Marijulie Martínez; Chih-Hao Lee; Clary B Clish; David T W Wong; Laurence D Parnell; Chao-Qiang Lai; José M Ordovás; JoAnn E Manson; Frank B Hu; Meir J Stampfer; Katherine L Tucker; Kaumudi J Joshipura; Shilpa N Bhupathiraju Journal: BMJ Open Diabetes Res Care Date: 2021-08