Dara M Shearer1, W Murray Thomson1, Jonathan M Broadbent2, Jim Mann3,4, Richie Poulton5. 1. Department of Oral Sciences, Faculty of Dentistry, University of Otago, Dunedin, New Zealand. 2. Department of Oral Rehabilitation, Faculty of Dentistry, University of Otago, Dunedin, New Zealand. 3. Department of Human Nutrition, University of Otago, Dunedin, New Zealand. 4. Edgar National Centre for Diabetes and Obesity Research, Dunedin, New Zealand. 5. Dunedin Multidisciplinary Health and Development Research Unit, University of Otago, Dunedin, New Zealand.
Abstract
AIM: To examine associations between periodontitis and developmental trajectories of glycated haemoglobin (HbA1c) during the third and fourth decades in an initially healthy sample. MATERIALS AND METHODS: HbA1c data collected at ages 26, 32 and 38 in the prospective Dunedin Multidisciplinary Health and Development Study were used to assign study members (n = 893) to trajectories applying group-based trajectory modelling (GBTM). The model allowed the statistical linking of baseline demographic, smoking and waist-height ratio covariates to group membership probability; and added a time-varying covariate (periodontitis) to the trajectories themselves to examine whether events that occurred during the course of the trajectory altered its course. RESULTS: Three HbA1c trajectory groups were identified: "Low" (n = 98, 11.0%); "Medium" (n = 482, 54.0%); and "High" (n = 313, 35.0%) with mean HbA1c of 29.6, 34.1 and 38.7 mmol/mol, respectively, at age 38. Having periodontitis at 32 and 38 was associated with an upward shift in the trajectories. However, none of the associations were statistically significant. CONCLUSIONS: Periodontitis was not found to be associated with dysglycaemia over 12 years from early adulthood into early middle age. This suggests that any influence periodontitis may have on dysglycaemia develops later in life.
AIM: To examine associations between periodontitis and developmental trajectories of glycated haemoglobin (HbA1c) during the third and fourth decades in an initially healthy sample. MATERIALS AND METHODS: HbA1c data collected at ages 26, 32 and 38 in the prospective Dunedin Multidisciplinary Health and Development Study were used to assign study members (n = 893) to trajectories applying group-based trajectory modelling (GBTM). The model allowed the statistical linking of baseline demographic, smoking and waist-height ratio covariates to group membership probability; and added a time-varying covariate (periodontitis) to the trajectories themselves to examine whether events that occurred during the course of the trajectory altered its course. RESULTS: Three HbA1c trajectory groups were identified: "Low" (n = 98, 11.0%); "Medium" (n = 482, 54.0%); and "High" (n = 313, 35.0%) with mean HbA1c of 29.6, 34.1 and 38.7 mmol/mol, respectively, at age 38. Having periodontitis at 32 and 38 was associated with an upward shift in the trajectories. However, none of the associations were statistically significant. CONCLUSIONS:Periodontitis was not found to be associated with dysglycaemia over 12 years from early adulthood into early middle age. This suggests that any influence periodontitis may have on dysglycaemia develops later in life.
Authors: W Murray Thomson; Jonathan M Broadbent; David Welch; James D Beck; Richie Poulton Journal: J Clin Periodontol Date: 2007-10 Impact factor: 8.728
Authors: Lydie N Pani; Leslie Korenda; James B Meigs; Cynthia Driver; Shadi Chamany; Caroline S Fox; Lisa Sullivan; Ralph B D'Agostino; David M Nathan Journal: Diabetes Care Date: 2008-07-15 Impact factor: 17.152
Authors: K G Peres; W M Thomson; B W Chaffee; M A Peres; N Birungi; L G Do; C A Feldens; M Fontana; T A Marshall; W Pitiphat; W K Seow; Y Wagner; H M Wong; A J Rugg-Gunn Journal: J Dent Res Date: 2020-07-17 Impact factor: 6.116
Authors: Dara M Shearer; W Murray Thomson; Claire M Cameron; Sandhya Ramrakha; Graham Wilson; Tien Yin Wong; Michael J A Williams; Rachael McLean; Reremoana Theodore; Richie Poulton Journal: Community Dent Oral Epidemiol Date: 2018-08-30 Impact factor: 3.383