AIM: To investigate coagulatory factors in predicting response to neoadjuvant therapy (NeoTr) in esophageal cancer (EC). METHODS: We investigated the relevance of coagulatory factors in 84 EC patients (56 adenocarcinomas, 28 squamous cell cancer) who received NeoTr. Plasma fibrinogen (PFR), peripheral blood platelet counts (PBPC) and C-reactive protein (CRP) were determined before NeoTr. Response was classified as tumor regression grades. RESULTS: Patients with good response to NeoTr had significantly higher PFR (p = 0.006), CRP (p = 0.002) and PBPC levels (p = 0.034) when compared with others. Only, PFR remained an independent factor influencing tumor regression (p = 0.0064, coefficient of regression: -0.003). No association with survival was observed. CONCLUSION: PFR and to a lesser extent PBPC and CRP might be considered as a predictive marker for the response to NeoTr in EC.
AIM: To investigate coagulatory factors in predicting response to neoadjuvant therapy (NeoTr) in esophageal cancer (EC). METHODS: We investigated the relevance of coagulatory factors in 84 EC patients (56 adenocarcinomas, 28 squamous cell cancer) who received NeoTr. Plasma fibrinogen (PFR), peripheral blood platelet counts (PBPC) and C-reactive protein (CRP) were determined before NeoTr. Response was classified as tumor regression grades. RESULTS:Patients with good response to NeoTr had significantly higher PFR (p = 0.006), CRP (p = 0.002) and PBPC levels (p = 0.034) when compared with others. Only, PFR remained an independent factor influencing tumor regression (p = 0.0064, coefficient of regression: -0.003). No association with survival was observed. CONCLUSION: PFR and to a lesser extent PBPC and CRP might be considered as a predictive marker for the response to NeoTr in EC.
Authors: Shu Jie Huang; Dan Tian; Si Chao Wang; Rui Jie Zeng; Yue Jiao Dong; Liang Li Hong; Han Sheng Wu; Fang Ping Xu; Dong Kun Zhang; Liang Xie; Hai Yu Zhou; Ji Ming Tang; Xiao Song Ben; Gang Chen; Ri Xin Chen; Yong Tang; Gui Bin Qiao Journal: World J Oncol Date: 2022-08-23