Literature DB >> 25796970

Targeting dengue virus NS4B protein for drug discovery.

Xuping Xie1, Jing Zou2, Qing-Yin Wang3, Pei-Yong Shi4.   

Abstract

The flavivirus nonstructural 4B protein (NS4B) has recently emerged as a valid antiviral target for drug discovery. Here we review (i) the current understanding of the structure and function of DENV NS4B, (ii) the approaches that have been taken to identify NS4B inhibitors, and (iii) the known inhibitors of flavivirus NS4B protein. This article forms part of a symposium in Antiviral Research on flavivirus drug discovery.
Copyright © 2015 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Antivirals; Dengue; Flavivirus; NS4B; Nonstructural protein 4B

Mesh：

Substances：

Year:  2015        PMID： 25796970     DOI： 10.1016/j.antiviral.2015.03.007

Source DB:  PubMed          Journal:  Antiviral Res        ISSN： 0166-3542            Impact factor:   5.970


  27 in total

1.  Mutation of Putative N-Glycosylation Sites on Dengue Virus NS4B Decreases RNA Replication.

Authors:  Nenavath Gopal Naik; Huey-Nan Wu
Journal:  J Virol       Date:  2015-04-15       Impact factor: 5.103

Review 2.  Biochemistry and Molecular Biology of Flaviviruses.

Authors:  Nicholas J Barrows; Rafael K Campos; Kuo-Chieh Liao; K Reddisiva Prasanth; Ruben Soto-Acosta; Shih-Chia Yeh; Geraldine Schott-Lerner; Julien Pompon; October M Sessions; Shelton S Bradrick; Mariano A Garcia-Blanco
Journal:  Chem Rev       Date:  2018-04-13       Impact factor: 60.622

Review 3.  Approved Antiviral Drugs over the Past 50 Years.

Authors:  Erik De Clercq; Guangdi Li
Journal:  Clin Microbiol Rev       Date:  2016-07       Impact factor: 26.132

Review 4.  Broad-spectrum agents for flaviviral infections: dengue, Zika and beyond.

Authors:  Veaceslav Boldescu; Mira A M Behnam; Nikos Vasilakis; Christian D Klein
Journal:  Nat Rev Drug Discov       Date:  2017-05-05       Impact factor: 84.694

5.  Escape Mutations in NS4B Render Dengue Virus Insensitive to the Antiviral Activity of the Paracetamol Metabolite AM404.

Authors:  Koen W R van Cleef; Gijs J Overheul; Michael C Thomassen; Jenni M Marjakangas; Ronald P van Rij
Journal:  Antimicrob Agents Chemother       Date:  2016-03-25       Impact factor: 5.191

6.  In silico targeting of non-structural 4B protein from dengue virus 4 with spiropyrazolopyridone: study of molecular dynamics simulation, ADMET and virtual screening.

Authors:  Waqar Hussain; Iqra Qaddir; Sajid Mahmood; Nouman Rasool
Journal:  Virusdisease       Date:  2018-03-29

7.  Discovery of Dengue Virus NS4B Inhibitors.

Authors:  Qing-Yin Wang; Hongping Dong; Bin Zou; Ratna Karuna; Kah Fei Wan; Jing Zou; Agatha Susila; Andy Yip; Chao Shan; Kim Long Yeo; Haoying Xu; Mei Ding; Wai Ling Chan; Feng Gu; Peck Gee Seah; Wei Liu; Suresh B Lakshminarayana; CongBao Kang; Julien Lescar; Francesca Blasco; Paul W Smith; Pei-Yong Shi
Journal:  J Virol       Date:  2015-08       Impact factor: 5.103

8.  Identification of a Pyridoxine-Derived Small-Molecule Inhibitor Targeting Dengue Virus RNA-Dependent RNA Polymerase.

Authors:  Hong-Tao Xu; Susan P Colby-Germinario; Said Hassounah; Peter K Quashie; Yingshan Han; Maureen Oliveira; Brent R Stranix; Mark A Wainberg
Journal:  Antimicrob Agents Chemother       Date:  2015-11-16       Impact factor: 5.191

9.  A Novel Benzodiazepine Compound Inhibits Yellow Fever Virus Infection by Specifically Targeting NS4B Protein.

Authors:  Fang Guo; Shuo Wu; Justin Julander; Julia Ma; Xuexiang Zhang; John Kulp; Andrea Cuconati; Timothy M Block; Yanming Du; Ju-Tao Guo; Jinhong Chang
Journal:  J Virol       Date:  2016-11-14       Impact factor: 5.103

10.  A Novel Series of Indole Alkaloid Derivatives Inhibit Dengue and Zika Virus Infection by Interference with the Viral Replication Complex.

Authors:  Christophe Pannecouque; Dominique Schols; Antonios Fikatas; Peter Vervaeke; Eef Meyen; Nuria Llor; Sergi Ordeix; Ine Boonen; Magda Bletsa; Liana Eleni Kafetzopoulou; Philippe Lemey; Mercedes Amat
Journal:  Antimicrob Agents Chemother       Date:  2021-07-16       Impact factor: 5.191
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